Category: 58602-02-1

Adding a certain compound to certain chemical reactions, such as: 58602-02-1, 2,6-Difluoro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 58602-02-1, blongs to pyridine-derivatives compound. name: 2,6-Difluoro-3-nitropyridine

Step A 2,6-difluoro-3-nitropyridine (14.68g,91.8mmol) was added to a mixture of DL-alanine ethyl ester hydrochloride (14.09g 92mmol) and potassium carbonate (25.3g, 183mmol) in acetonitrile (200ml) and the mixture stirred for 2 hours at room temperature. The reaction mixture was poured into water and extracted several times with ethyl acetate; the combined extracts were dried (MgSO4) and the solvent removed in vacuo leaving a viscous orange-yellow residue which solidified on standing. The solid was triturated with hexane and the solvent removed from the hexane soluble fraction leaving ethyl DL-2-[6-fluoro-3-nitropyridyl-2-amino]propionate as a yellow solid m.p. 49-51 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58602-02-1, its application will become more common.

Reference:
Patent; Imperial Chemical Industries PLC; US5133798; (1992); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 58602-02-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58602-02-1, name is 2,6-Difluoro-3-nitropyridine, molecular formula is C5H2F2N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

b 2-(Ethylamino)-6-fluoro-3-nitropyridine To a solution of 2,6-difluoro-3-nitropyridine (45.7 g, 285 mmol) in THF (500 mL) at -40 C. was added drop-wise a solution of ethylamine (25.7 g, 570 mmol) in THF (250 mL). After 30 min, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in EtOAc. The organic phase was washed with brine, dried (MgSO4), filtered and concentrated. The resulting yellow solid was purified by flash chromatography (15% EtOAc in hexane) to give the title compound (43.2 g, 82% yield) as a yellow solid.

According to the analysis of related databases, 58602-02-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Simoneau, Bruno; US2002/28807; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58602-02-1, name is 2,6-Difluoro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H2F2N2O2

STEP B: 6-Fluoro-2-(3,4-methylenedioxyanilino)-3-nitropyridine In 75 ml. of ethanol was dissolved 3.2 g. (0.002 mole) of 2,6-difluoro-3-nitropyridine followed by 1.68 g. (0.02 mole) of sodium bicarbonate. To this stirred mixture, was added a solution of 2.74 g. (0.02 mole) of 3,4-(methylenedioxy) aniline in 50 ml. of ethanol dropwise over 45 minutes at room temperature. After one hour, 100 ml. of water was added and the deep-red crystalline solid product was collected. A small amount was crystallized from ethanol and melted at 161-162 C.

With the rapid development of chemical substances, we look forward to future research findings about 58602-02-1.

Reference:
Patent; Merck & Co., Inc.; US4144341; (1979); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 58602-02-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58602-02-1, name is 2,6-Difluoro-3-nitropyridine, molecular formula is C5H2F2N2O2, molecular weight is 160.0784, as common compound, the synthetic route is as follows.

EXAMPLE 4 1-(6-Fluoro-3-nitro-2-pyridinyl)-4-carbobenzoxypiperazine-2-carboxylic acid In a similar procedure to that described in Example 1, from 6.0 g. of 2,6-difluoro-3-nitropyridine, 9.0 g. of 4-carbobenzoxypiperazine-2-carboxylic acid, hydrochloride, 20 ml. of triethylamine and 150 ml. of dimethyl sulfoxide, there is obtained 14 g. of the title product as a viscous orange glass. Thin layer chromatographic analysis of this material shows essentially one spot.

The chemical industry reduces the impact on the environment during synthesis 58602-02-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; American Home Products Corporation; US4138564; (1979); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 58602-02-1, Adding some certain compound to certain chemical reactions, such as: 58602-02-1, name is 2,6-Difluoro-3-nitropyridine,molecular formula is C5H2F2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58602-02-1.

Synthesis of 2,6-difluoro-3-aminopyridine 2,6-Difluoro-3-nitropyridine (3.84 g) was dissolved in ethanol (42 ml). A solution of iron powder (4.03 g) and ammonium chloride (2.57 g) in water (14 ml) was added, and the reaction solution was heated and stirred at 80C for one hour. After leaving to cool, the reaction solution was filtered through celite. Ethyl acetate and water were added and the organic layer was separated. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The drying agent was separated by filtration, and then the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (2.06 g). The property values of the compound are as follows. 1H-NMR (CDCl3) delta (ppm): 3.66 (brs, 2H), 6.65 (dd, J=8.2, 3.0Hz, 1H), 7.22 (ddd, 10.4, 8.2, 6.8Hz, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 58602-02-1, 2,6-Difluoro-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2181992; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem