Category: 58757-38-3

Adding a certain compound to certain chemical reactions, such as: 58757-38-3, 6-Chloronicotinoyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H3Cl2NO, blongs to pyridine-derivatives compound. HPLC of Formula: C6H3Cl2NO

Example 23 6-([3-(Cyclopropylmethyl)-2,3,4,5-tetrahydro-1 H-3-benzazepin-7-yl]oxy}-N-methyl-3- pyridinecarboxamide (E23) Step 1: 6-Chloro-N-methyl-3-pyridinecarboxamide; 2M Methylamine in tetrahydrofuran (100 ml, 200 mol) was cooled to 0C and 6- chloronicotinoyl chloride (10.6g, 60 mmol) dissolved in dichloromethane (30 ml) was added dropwise. The solution was stirred to room temperature overnight and concentrated in vacuo. The residue was partitioned between dichloromethane and water, the aqueous phase was extracted with dichloromethane (x3). The combined extracts were washed with water, saturated brine and dried over anhydrous magnesium sulphate. The filtrate was concentrated to a crude solid that was used without further purification. (ES+) m/e 171 [M+H]+.

The synthetic route of 58757-38-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2005/97778; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 58757-38-3, name is 6-Chloronicotinoyl chloride. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H3Cl2NO

4-Aminoresorcinol HCI (620 mg, 2.8 mmol) was slurried in THF (10 ml) and triethylamine (1.6 ml, 3 eq) was added. To the stirred solution, cooled with an ice-bath, 6-chloronicotinoyl chloride (2.0 g, 3 eq) dissolved in THF (15 ml) was added dropwise. After the addition the mixture was allowed to stir for 3 days at rt. The reaction was poured out on ice and the solid was filtered. The wet solid was dissolved in THF (25 ml) and ethanol (25 ml) by heating. 2 M NaOH (20 ml) was added dropwise to the still warm solution. After 10 min the organic solvent was removed on the rotory evaporator and the mixture dissolved by adding more water. The solution was neutralized wit 6 M HCI (6 ml) and the solid was filtered to give 6-chloro-N-(2,4-dihydroxyphenyl)pyridine-3- carboxamide (0.71 g, 71% yield, m/z (M-l) 263.1).

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Reference:
Patent; KARIN & STEN MORTSTEDT CBD SOLUTIONS AB; SOHN, Daniel Dungan; (185 pag.)WO2019/197502; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem