Synthetic Route of 588727-65-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 588727-65-5, name is 4-(6-Bromopyridin-2-yl)benzaldehyde. A new synthetic method of this compound is introduced below.
Step 2. 4-[6-(4-Trifluoromethoxyphenyl)-pyridin-2-yl]-benzaldehyde. 4-(6-Bromo- pyridin-2-yl)-benzaldehyde (0.31 mmol), 4-trifluoromethoxyphenyl boronic acid (0.46 mmol), tetrakis(triphenylphosphine)palladium(0) (0.003 mmol), 2 M potassium carbonate (0.31 mL) and dioxane (2 mL) were combined in a vial and irradiated by microwave for 10 min at 150 0C. The reaction mixture was taken up in ether and washed with brine. The organic layer was dried over magnesium sulfate, was filtered and the solvent removed in vacuo. Purification by silica gel chromatography (EtOAc/hexanes) yielded the product (80 mg) as an off-white solid: mp 109-112 0C; 1H NMR (400 MHz, CDCl3) delta 10.11 (s, IH), 8.32 (d, J = 8.5 Hz, 2H), 8.19 (d, J = 8.1 Hz, 2H), 8.03 (d, J = 8.4 Hz, 2H), 7.89 (t, J = 7.9 Hz, IH), 7.79 (d, J = 7.7 Hz, IH), 7.74 (d, J = 8.0 Hz, IH), 7.35 (d, J = 8.3 Hz, 2H); EIMS m/z 343 (M+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,588727-65-5, 4-(6-Bromopyridin-2-yl)benzaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; DOW AGROSCIENCES LLC; LAMBERT, William; CROUSE, Gary; SPARKS, Thomas; CUDWORTH, Denise; WO2011/17513; (2011); A1;,
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