Category: 59020-10-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59020-10-9, name is 3-(Tributylstannyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 59020-10-9

Example 54 (Sp) -8-(3-Pyridinyl)adenosine-2’O-(tert- butyldimethylsilyl)-3′,5′-cyclic N-phenylphosphoramidate (5j); A mixture of Pd (OAc)2 0.166 mmol) and PPh3 (91mg, 0.348 mmol) in NMP (4 ml) was stirred at 50 C until the solution had turned dark red. A solution of (Sp)-8- bromoadenosine-2’O-(tert-butyldimethylsilyl)-3′,5′-cyclic N-phenylphosphoramidate (4) (0.500 g, 0.83 mmol) in NMP (2 ml) and 3- (tributylstannyl)pyridine g, 1.66 mmol) were added. The reaction mixture was stirred at 110 C for 10 h before the NMP was removed at reduced pressure and the residual material subjected to flash chromatography on silica gel using 7.5% MeOH in CH2Cl2. The product was a white solid contaminated with traces of organotin residues which were removed by dissolution of the the coupling product in CH2Cl2 and reprecipitation by hexane; yield 0.280 g (57%); HRMS (electrospray) : M+H 596.2211. Calc. for C27H34N7O5PSi+H: 596.2201. ¹H NMR (CDC1,, 300 MHz) : No. (CDCl3)-0.16 (3H, s, CH3),-0.15 (3H, s, CH,) , 0.60 (9H, s, C(CH3)3) , 4.30 – 4.43 (lH, m, H-4′), 4.60 – 4.68 (2H, m, OCH,), 5.15 (lH, d, J 5.2 Hz, H-2′), 5.69 (lH, s, H-1′), 5.75 – 5.82 (lH, m, H-3′), 6.37 (2H, bs, NH2), 6.58 (lH, d, J 9.2 Hz, NH), 6.99 – 7.10 (3H, m, 3 x H-Ph), 7.17 – 7.24 (2H, t, J 7.4 Hz, 2 x H-Ph), 7.42 – 7.48 (lH, m, H-pyr), 8.02 – 8.06 (lH, m, H-pyr), 8.37 (lH, s, H-2), 8.76 – 8.79 (lH, m, H-pyr), 8.97 (lH, d, J 1.7 Hz, H-pyr); ¹3C NMR (CDCl3,75 MHz) : 8 -5.5 and -4.8 (2 x CH3) , 18. 0 (Si-C), 25.4 (3 x CH3), 68.9 (d, J 6.8 Hz, OCH,), 71.3 (d, J 4 .5 Hz, CH-4′), 73.3 (d. J 8.8 Hz, CH-2′), 77.5 (d, J 3.8 Hz, CH-3′), 94.2 (CH-1′), 119.4,119.5, 119.6,122.9, 123.5, 125.0,129.1, 129.1,136.8, 138.5,148.1, 149.8,150.3, 151.4,153.5, 155.9.

With the rapid development of chemical substances, we look forward to future research findings about 59020-10-9.

Reference:
Patent; LAURAS AS; COCKBAIN, Julian; WO2005/123755; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59020-10-9, name is 3-(Tributylstannyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C17H31NSn

147a. 6-Chloro-3-(1-methyl-2-(S)-pyrrolidinylmethoxy)-5-(3-pyridyl)pyridine To a solution of 3-(1-methyl-2-(S)-pyrrolidinylmethoxy)-5-bromo-6-chloropyridine (500 mg, 1.28 mmol) in toluene (10 mL) was added 3-pyridinyltributyltin (564 mg, 1.54 mmol) and tetrakis(triphenylphosphine)palladium(0) (45 mg, 0.04 mmol). After being heated under reflux for 16 h, the resulting mixture was cooled to room temperature. Solvent was removed, and the residue was chromatographed (silica gel; EtOAc/hexane, 2:19 to 1:1) to afford an oil (428 mg, 86%): 1 H NMR (CDCl3, 300 MHz) delta1.45 (s, 9H), 1.94 (m, 1H), 1.98-2.10 (m, 2H), 3.31-3.45 (m, 2H), 3.88-4.30 (m, 4H), 7.22 (m, 1H), 7.40 (m, 1H), 7.83 (td, 1H, J=1.5, 9.0 Hz), 8.16 (d, 1H, J =3.0 Hz), 8.64-8.73 (m, 2H); MS (CI/NH3) m/z 390 (M+H)+.

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Reference:
Patent; Abbott Laboratories; US6127386; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem