Category: 59281-14-0

Reference of 59281-14-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 59281-14-0 as follows.

(B) 2-(Chloromethyl)-5-(phenylmethoxy)-4(1H)pyridinone, monohydrochloride A suspension of 2-(hydroxymethyl)-5-(phenylmethoxy)-4(1H)-pyridinone (3 g, 12.99 mmole) in chloroform (15 ml) was cooled to 0 under argon and treated with thionyl chloride (6.1 ml, 83.62 mmole). Within several minutes, a homogeneous solution was obtained. After stirring an additional 5 minutes, a cream colored solid precipitated. The cooling bath was removed and the mixture was heated at reflux for 45 minutes. The mixture was cooled to 0 and the white precipitate was filtered, washed with chloroform and hexane and dried in vacuo. The yield of the title compound was 3.65 g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59281-14-0, its application will become more common.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4743685; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59281-14-0, name is 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one, the common compound, a new synthetic route is introduced below. SDS of cas: 59281-14-0

3 Oc) (2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-methanolA solution of pyridinone (30b) (12.6 g) in water (1.4 1)containing sodium hydroxide (4.36 g) was hydrogenated over 10%palladium on charcoal (6.7 g) for 2 days. The mixture wasfiltered and the filtrate lyophilised.

The synthetic route of 59281-14-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MORPHOCHEM AKTIENGESELLSCHAFT FUeR KOMBINATORISCHE CHEMIE; WO2006/21448; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 59281-14-0, 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C13H13NO3, blongs to pyridine-derivatives compound. COA of Formula: C13H13NO3

A. Synthesis of [5-(benzyloxy)-4-isopropoxypyridin-2-yl]methanol (C32). A solution of 5-(benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one (prepared by a procedure similar to that reported by M. M. O’Malley et al., Organic Letters 2006, 8, 2651-2652) (1.3 g, 5.6 mmol) in N,N-dimethylformamide (11.2 mL) was treated with 2-iodopropane (95%, 1.77 mL, 16.8 mmol) and potassium carbonate (1.17 g, 8.42 mmol). The slurry was stirred for 2.5 hours at room temperature and then heated at 80 C. for 18 hours, with addition of 2-iodopropane (1.3 mL, 12 mmol) after the first hour. The mixture was extracted three times with ethyl acetate, and the combined organic layers were dried over sodium sulfate. Filtration and removal of solvent in vacuo gave a residue, which was purified by silica gel chromatography (Eluants: 0%, then 20%, then 40% 2-propanol in ethyl acetate) to provide the product as a brown solid. Yield: 700 mg, 2.56 mmol, 46%. 1H NMR (400 MHz, DMSO-d6) delta 8.06 (s, 1H), 7.30-7.44 (m, 5H), 7.06 (s, 1H), 5.28 (t, J=5.9 Hz, 1H), 5.13 (s, 2H), 4.72 (septet, J=6.0 Hz, 1H), 4.42 (d, J=5.9 Hz, 2H), 1.32 (d, J=6.0 Hz, 6H).

The synthetic route of 59281-14-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; Brodney, Michael Aaron; Efremov, Ivan Viktorovich; Helal, Christopher John; O’Neill, Brian Thomas; US2013/150376; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 59281-14-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59281-14-0, name is 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one, molecular formula is C13H13NO3, molecular weight is 231.25, as common compound, the synthetic route is as follows.

General procedure: 20 mmol of compound 4 (4a-4f) was weighed into 100 mL of dichloromethane, Then add 0.16 mol of manganese dioxide, The mixed system was heated under reflux at 50 C in a oil bath for 72-96 h, and the TLC spot plate was used to detect the reaction process. After the reaction is over, The manganese dioxide was removed by suction filtration and the solvent 5 was evaporated to give compound 5.

Statistics shows that 59281-14-0 is playing an increasingly important role. we look forward to future research findings about 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one.

Reference:
Patent; Zhejiang Gongshang University; Zhou Tao; Shao Lele; (12 pag.)CN106986819; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 59281-14-0, 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C13H13NO3, blongs to pyridine-derivatives compound. Computed Properties of C13H13NO3

To a stirred solution of compound 9b (2.7g) in NaOH solution (0.567g in 55 mL of water) was added 10%Pd-C(l .4g) portion wise under nitrogen atmosphere. The nitrogen was replaced with hydrogen and stirred at RT for 16h. The reaction mass was filtered under celite and concentrated under reduced pressure to give 2.2 g of the required compound as a mixture. Proceeded with crude to the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,59281-14-0, 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder; WO2014/57415; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem