Category: 59290-82-3

《A B2(OH)4-Mediated Synthesis of 2-Substituted Indazolone and Its Application in a DNA-Encoded Libraryã€?was written by Bao, Yapeng; Deng, Zongfa; Feng, Jing; Zhu, Weiwei; Li, Jin; Wan, Jinqiao; Liu, Guansai. COA of Formula: C6H4N2O4 And the article was included in Organic Letters on August 21 ,2020. The article conveys some information:

Indazolone cores are among the most common structural components in medicinal chem. and can be found in many biol. active mols. In this report, a mild and efficient approach to 2-substituted indazolones via B2(OH)4-mediated reductive N-N bond formation is developed. This strategy features mild conditions, no request for a metal catalyst, and a wide scope for both aliphatic and aromatic amines. Meanwhile, this method was further successfully applied on DNA to construct indazolone cores for a DNA-encoded library. This will enable the production of a very attractive indazolone-cored library from simple amines and scaffolds, which will provide considerable diversity. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3COA of Formula: C6H4N2O4)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.COA of Formula: C6H4N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gawinecki, Ryszard; Rasala, Danuta; Obrzut, Jan; Tamasik, Piotr published their research in Chemica Scripta on December 31 ,1985. The article was titled 《The ortho effect in pyridines. VI. Singlet → singlet π → π* excited state of 2- and 4-substituted 3-nitropyridines》.Application In Synthesis of 3-Nitroisonicotinic acid The article contains the following contents:

The UV absorption spectra in ethanol were measured for o-substituted nitrobenzenes, 2-substituted-3-nitropyridines and 4-substituted-3-nitropyridines. Based on bathochromic shift of the ICT band and its intensity, the ortho effect is discussed in the singlet→singlet π→π* excited state of investigated compounds In the experiment, the researchers used 3-Nitroisonicotinic acid(cas: 59290-82-3Application In Synthesis of 3-Nitroisonicotinic acid)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C6H4N2O4On May 22, 2013, Kaplanek, Robert; Krchnak, Viktor published an article in Tetrahedron Letters. The article was 《Fast and effective reduction of nitroarenes by sodium dithionite under PTC conditions: application in solid-phase synthesis》. The article mentions the following:

Herein, conditions for the fast and effective reduction of aromatic nitro groups bound to hydrophobic polystyrene-based Wang and Rink resins utilizing sodium dithionite in dichloromethane-water under PTC conditions are reported. Tetrabutylammonium hydrogen sulfate (TBAHS) was found to be an effective phase-transfer catalyst for this reaction. This method allows for the reduction of nitro groups to amino groups under mild conditions with complete conversion and is tolerant of other functional groups. This method is a superior alternative to tin(II) chloride-based reduction, which is known for its shortcomings. After reading the article, we found that the author used 3-Nitroisonicotinic acid(cas: 59290-82-3Synthetic Route of C6H4N2O4)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Synthetic Route of C6H4N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bakke, Jan M.; Ranes, Eli; Riha, Jaroslav; Svensen, Harald published an article on February 28 ,1999. The article was titled 《The synthesis of β-nitropyridine compounds》, and you may find the article in Acta Chemica Scandinavica.HPLC of Formula: 59290-82-3 The information in the text is summarized as follows:

Pyridine and a number of substituted pyridines have been nitrated by reaction with N2O5 followed by reaction with an aqueous solution of SO2xH2O or NaHSO3. The dependence of the yields on the pH of the aqueous reaction medium, on the concentration of SO2xH2O-HSO3-, on addition of methanol to the aqueous phase, and on the reaction temperature were investigated. The yields obtained with NaHSO3 were: 3-nitropyridine 77%, 2-methyl-5-nitropyridine 36%, 3-methyl-5-nitropyridine 24%, 3-acetyl-5-nitropyridine 18%, 5-nitropyridine-3-carboxylic acid 15%, 3-chloro-5-nitropyridine 11%, 4-methyl-3-nitropyridine 39%, 4-acetyl-3-nitropyridine 67%, 4-cyano-3-nitropyridine 45%, 4-phenyl-3-nitropyridine 68%, 4-formyl-3-nitropyridine 62% (from reaction in liquid SO2), 3-nitropyridine-4-carboxylic acid 48%, Me 3-nitropyridine-4-carboxylate 75%, 2,3-dimethyl-5-nitropyridine 37%, 2,4-dimethyl-5-nitropyridine 64%, 3-nitroquinoline 10% and 4-nitroisoquinoline 42%. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3HPLC of Formula: 59290-82-3)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 59290-82-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Kai; Zhou, Zhiming; Song, Jinhong; Bi, Lixue; Shen, Ning; Wu, Yukai; Chen, Fuxue; Wen, Hongliang published their research in Journal of Hazardous Materials on December 15 ,2010. The article was titled 《A metal-free aerobic oxidation of nitrotoluenes catalyzed by N,N’,N”-trihydroxyisocyanuric acid (THICA) and a novel approach to the catalyst》.Safety of 3-Nitroisonicotinic acid The article contains the following contents:

A metal-free catalytic system with N,N’,N”-trihydroxyisocyanuric acid (THICA) as the catalyst for the oxidation of nitrotoluenes is introduced, and a novel Pd-free approach for the synthesis of THICA was developed. In a solution of acetic acid, THICA and concentrated nitric acid, nitrotoluenes especially polynitrotoluenes such as 2,4,6-trinitrotoluene (TNT), were converted into the desired carboxylic acids under 0.2 MPa of O2 at 100 °C with yields up to 99%. THICA was synthesized from N-hydroxyphtalimide through a four-step synthesis in a total yield of 46%. A possible mechanism of this catalytic process was proposed where NO2 and nitric acid first induced a radical of THICA, which then abstracts a hydrogen atom from the Me on the aromatic ring to form a benzyl radical. This radical then initiates subsequent reactions. The production of the benzyl radical was supported by ESR measurements. In the experimental materials used by the author, we found 3-Nitroisonicotinic acid(cas: 59290-82-3Safety of 3-Nitroisonicotinic acid)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kralova, Petra; Malon, Michal; Soural, Miroslav published their research in ACS Combinatorial Science on December 11 ,2017. The article was titled 《Stereoselective Synthesis of Benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-6,12-diones with Two Diversity Positions》.Product Details of 59290-82-3 The article contains the following contents:

Herein, we report a stereoselective formation of tetrahydro-6H-benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-6,12(11H)-diones. Their preparation consisted in solid-phase synthesis of linear intermediates starting from polymer-supported Ser(tBu)-OH. Using various 2-nitrobenzoic acids and bromoketones, the key intermediates were obtained in five steps and subjected to trifluoroacetic acid-mediated cleavage from the resin, followed by stereoselective reduction with triethylsilane. Subsequent catalytic hydrogenation of the nitro group and cyclization yielded the target compounds with full retention of the C12a stereocenter configuration. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3Product Details of 59290-82-3)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 59290-82-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Yi; Obeng, Samuel; Wang, Huiqun; Jali, Abdulmajeed M.; Peddibhotla, Bharath; Williams, Dwight A.; Zou, Chuanchun; Stevens, David L.; Dewey, William L.; Akbarali, Hamid I.; Selley, Dana E.; Zhang, Yan published an article on January 24 ,2019. The article was titled 《Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands》, and you may find the article in Journal of Medicinal Chemistry.Recommanded Product: 59290-82-3 The information in the text is summarized as follows:

μ Opioid receptor (MOR) agonists have been widely applied for treating moderate to severe pain. However, numerous adverse effects have been associated with their application, including opioid-induced constipation (OIC), respiratory depression, and addiction. On the basis of previous work in our laboratory, NAP, a 6β-N-4′-pyridyl substituted naltrexamine derivative, was identified as a peripheral MOR antagonist that may be used to treat OIC. To further explore its structure-activity relationship, a new series of NAP derivatives were designed, synthesized, and biol. evaluated. Among these derivatives, NFP and NYP significantly antagonized the antinociception effect of morphine. Whereas NAP acted mainly peripherally, its derivatives NFP and NYP actually can act centrally. Furthermore, NFP produced significantly lesser withdrawal symptoms than naloxone at similar doses. These results suggest that NFP has the potential to be a lead compound to treat opioid abuse and addiction. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3Recommanded Product: 59290-82-3)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 59290-82-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fulopova, Veronika; Gucky, Tomas; Grepl, Martin; Soural, Miroslav published their research in ACS Combinatorial Science on December 10 ,2012. The article was titled 《Solid-Phase Synthesis of Trisubstituted Benzo[1,4]-Diazepin-5-one Derivatives》.Application In Synthesis of 3-Nitroisonicotinic acid The article contains the following contents:

Solid-phase synthesis of 3,4-dihydro-benzo[e][1,4]diazepin-5-ones with three diversity positions is described. Various primary amines were used as the starting material and immobilized on the polystyrene resin equipped with different acid-labile linkers. Polymer-supported amines were converted to α-amino ketones with the use of their sulfonylation with the 4-nitrobenzenesulfonyl chloride (4-Nos-Cl) and subsequent alkylation with α-bromo ketones. After the cleavage of the 4-Nos group, the corresponding α-amino ketones were acylated with various o-nitrobenzoic acids. Reduction of the nitro group followed by spontaneous on-resin ring closure gave the target immobilized benzodiazepines. After acid-mediated cleavage the products were obtained in very good crude purity and satisfactory yields, which makes the developed method applicable for simple library synthesis of the corresponding derivatives in a combinatorial fashion. In the part of experimental materials, we found many familiar compounds, such as 3-Nitroisonicotinic acid(cas: 59290-82-3Application In Synthesis of 3-Nitroisonicotinic acid)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Studies on anticoccidial agents. 11. Synthesis and anticoccidial activity of nitropyridinecarboxamides and derivatives》 was published in Journal of Medicinal Chemistry in 1977. These research results belong to Morisawa, Yasuhiro; Kataoka, Mitsuru; Kitano, Noritoshi. Electric Literature of C6H4N2O4 The article mentions the following:

Of 56 title compounds prepared, optimal in vivo activity against Eimeria tenella was shown by 2-nitroisonicotinamide (I, R1 = R2 = H) [60780-17-8] and 11 derivatives (I: R1 = H, Me; R2 = Me, CH2OH, alkanoyl, aryl acyl, heterocyclic acyl). Activity was shown by 2-, 3-, 5-, and 6-nitro-, but not by 4-nitropyridinecarboxamides. Substitution on the amide N of the various positional isomers affected their activity differently. In the part of experimental materials, we found many familiar compounds, such as 3-Nitroisonicotinic acid(cas: 59290-82-3Electric Literature of C6H4N2O4)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H4N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 3-Nitroisonicotinic acidOn September 30, 1991 ,《Proton, carbon-13 and oxygen-17 NMR study of substituted nitropyridines》 was published in Magnetic Resonance in Chemistry. The article was written by Kolehmainen, Erkki; Laihia, Katri; Rasala, Danuta; Gawinecki, Ryszard. The article contains the following contents:

1H, 13C and 17O NMR spectra for 22 substituted nitropyridines were measured and their 1H NMR spectra were analyzed. The most significant variations in the NMR parameters are found for isomeric hydroxy derivatives, owing to the possibility of keto-enol tautomerism. The prevalence of the keto form is observed in 2- and 4-hydroxy derivatives, while the 3-hydroxy derivative exists in its enol form. Among the three nuclei studied, 17O seems to be the best nucleus for probing the keto-enol tautomerism. No correlation is observed between the torsion angle of the nitro group and its 17O NMR chem. shift. Mol. mechanics calculations were performed to clarify the torsional energetics of the nitro group and the preferences for keto-enol tautomerism. In addition to this study using 3-Nitroisonicotinic acid, there are many other studies that have used 3-Nitroisonicotinic acid(cas: 59290-82-3Reference of 3-Nitroisonicotinic acid) was used in this study.

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem