Electric Literature of 5938-16-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5938-16-9, name is 4-(4-Methoxyphenyl)pyridine. A new synthetic method of this compound is introduced below.
To chloro sulfuric acid (10 mL) was added 4-(4-methoxy-phenyl)-pyridine (1.28 g, 6.91 mmol) portionwise at 0C and the mixture was stirred at room temperature for 4 h. The mixture was poured into ice-water, neutralized with saturated NaHC03 to pH = 7-8 and extracted with EtOAc (25 mL x3). The extracts were dried over Na2S04 and concentrated in vacuum to afford 600 mg (yield: 31%) of 2-methoxy-5-pyridin-4-yl-benzenesulfonyl chloride. [00200] 1H NMR (DMSO-d6): delta = 8.70 (IH, s), 8.29 (IH, s), 8.09 (IH, d), 7.77 (IH, d), 7.44- 7.41 (2H, m), 7.36 (IH, d), 4.12 (3H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5938-16-9, 4-(4-Methoxyphenyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; DAHL, Russell; COSFORD, Nicholas, D.P.; MILLAN, Jose, Luis; WO2013/126608; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem