Category: 59576-31-7

Application of 59576-31-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59576-31-7, name is 1-(4,6-Dimethylpyridin-2-yl)ethanone, molecular formula is C9H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 7: Preparation of compound P.10l-(4,6-Dimethyl-pyridin-2-yl)-ethanone (400mg) was dissolved in methanol (15ml_) and (E)-l-[6-(3-aminooxy-propyl)-pyridin-2-yl]-ethanone O-methyl-oxime (600mg) was added. After stirring for 70h at ambient temperature, the reaction mixture was concentrated and the residue was purified by chromatography over silica to give colorless oil (740mg). ^-NMR (CDCI3, 400 MHz):7.70 (d, IH), 7.55 (t, IH), 7.47 (s, 2H), 7.11 (d, IH), 6.93 (s, IH), 4.28 (t, 2H), 4.01 (s, 3H), 2.92 (t, 2H), 2.51 (s, 3H), 2.32 (s+s+s, 9H), 2.21 (m, 2H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59576-31-7, 1-(4,6-Dimethylpyridin-2-yl)ethanone.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; ZAMBACH, Werner; STIERLI, Daniel; NEBEL, Kurt; BORTOLATO, Andrea; MASSOL-FRIEH, Clara; WO2012/38521; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59576-31-7, name is 1-(4,6-Dimethylpyridin-2-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1-(4,6-Dimethylpyridin-2-yl)ethanone

At room temperature, a solution of 2.05 g (2.0 mmol) of 2-acetyl-5,6-dimethylpyridine (II-1) in 50 ml of ethanol and 30 mg of p-toluenesulphonic acid were added to a solution of 0.53 g (2.0 mmol) of (1E)-1-(5,6-dimethylpyridin-2-yl)ethanone O-({1-[(aminooxy)methyl]cyclopropyl}methyl)oxime (XII-8) in 10 ml of ethanol, and the mixture was heated under reflux for 4 h. After cooling, the reaction mixture was poured into ice-water and neutralized by addition of triethylamine. After extraction with dichloromethane, the combined organic phases were dried over Na2SO4 and freed from the solvent under reduced pressure. Purification by column chromatography on silica gel using cyclohexane/ethyl acetate gave 0.73 g (1.6 mmol, 79% of theory) of (1E)-1-(4,6-dimethylpyridin-2-yl)ethanone O-({1-[({[(1E)-1-(5,6-dimethylpyridin-2-yl)ethylidene]amino}oxy)methyl]cyclopropyl}methyl)oxime of logP (HCO2H)=2.61.

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Reference:
Patent; BAYER CROPSCIENCE AG; US2010/22559; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem