Category: 59718-84-2

Subramanyam, Chakrapani et al. published their research in Tetrahedron Letters in 1996 | CAS: 59718-84-2

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 59718-84-2

A convenient synthesis of 3-substituted pipecolic acid methyl esters was written by Subramanyam, Chakrapani;Chattarjee, Sankar;Mallamo, John P.. And the article was included in Tetrahedron Letters in 1996.Recommanded Product: 59718-84-2 This article mentions the following:

A practical synthesis of the title compounds from com. available 3-hydroxy-2-pyridinecarboxylic acid is reported. The key step involves a Pd-catalyzed cross-coupling reaction of triflate I with the appropriate alkyl or aryl derivatives to generate substituted picolinic acid esters. Catalytic reduction of these esters provides the title compounds in good yields. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Recommanded Product: 59718-84-2).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 59718-84-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Qiang et al. published their research in Gaofenzi Cailiao Kexue Yu Gongcheng in 2011 | CAS: 59718-84-2

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C8H9NO2

Electro-generation of 3-methyl-2-formylaminopyridine in ferrocene modified bipolar membrane equipped cell was written by Chen, Qiang;Chen, Zhen;Wang, Yanhong;Zheng, Xi;Chen, Xiao;Chen, Riyao. And the article was included in Gaofenzi Cailiao Kexue Yu Gongcheng in 2011.Computed Properties of C8H9NO2 This article mentions the following:

The mSA-mCS bipolar membrane (BPM) was prepared by sodium alginate (SA) and chitosan (CS) modified by ferrocene and glutaraldehyde as linking reagents, resp., marked FSA-mCS BPM. FSA-mCS BPM was characterized by Fourier transform IR spectrum (FT-IR), I-V curves, OH– permeability. The interlayer property of the modified BPM was investigated by AC impedance. The FSA-mCS BPM was used as a separator in the electrolysis cell to prepare electro-generate 3-methyl-2-formylaminopyridine. The production yield is 60%, which is higher than that of Fe3+ modified mSA-mCS BPM or Nafion mono-membrane equipped cell. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Computed Properties of C8H9NO2).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C8H9NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bugaenko, Dmitry I. et al. published their research in Organic Letters in 2021 | CAS: 59718-84-2

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 59718-84-2

From Pyridine-N-oxides to 2-Functionalized Pyridines through Pyridyl Phosphonium Salts: An Umpolung Strategy was written by Bugaenko, Dmitry I.;Yurovskaya, Marina A.;Karchava, Alexander V.. And the article was included in Organic Letters in 2021.HPLC of Formula: 59718-84-2 This article mentions the following:

The reactions of pyridine-N-oxides with Ph3P under the developed conditions provide an unprecedented route to (pyridine-2-yl)phosphonium salts. Upon activation with DABCO, these salts readily serve as functionalized 2-pyridyl nucleophile equivalent This umpolung strategy allows for the selective C2 functionalization of the pyridine ring with electrophiles, avoiding the generation and use of unstable organometallic reagents. The protocol operated at ambient temperature and tolerated sensitive functional groups, enabling the synthesis of otherwise challenging compounds In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2HPLC of Formula: 59718-84-2).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 59718-84-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Heng et al. published their research in Heterocycles in 2013 | CAS: 59718-84-2

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application of 59718-84-2

Synthesis of 4-methoxy and 5-methoxy substituted 7-aza-isoindolin-1-ones was written by Zhou, Heng;Sun, Guanglong;Liu, Zenglu;Zhan, Xiaoping;Mao, Zhenmin. And the article was included in Heterocycles in 2013.Application of 59718-84-2 This article mentions the following:

A simple and convenient route for the synthesis of a series of 4-methoxy or 5-methoxy substituted 7-aza-isoindolin-1-ones is described. Methoxyl substituted pyridine derivatives were cyclized with different amines under alk. condition to give the desired products. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Application of 59718-84-2).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application of 59718-84-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dunn, A. D. et al. published their research in Journal fuer Praktische Chemie (Leipzig) in 1987 | CAS: 59718-84-2

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C8H9NO2

Synthesis of new thiopyranopyridines was written by Dunn, A. D.. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1987.Formula: C8H9NO2 This article mentions the following:

Thiopyranopyridinecarboxylates I and II (X, Y = CH, N; R = OH, NH2) are prepared from pyridine esters (e.g., III; R1 = Me, R2 = CO2Me; R1 = CO2Me, R2 = Me) and nitriles (e.g., III; R1 = Me, R2 = CN) by photochem. bromination, followed by substitution reaction of the resulting bromomethyl derivative with HSCH2CO2Me, and then base-induced intramol. cyclocondensation. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Formula: C8H9NO2).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C8H9NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

8 Sep 2021 News A new synthetic route of 59718-84-2

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59718-84-2, Methyl 3-methylpicolinate.

Application of 59718-84-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59718-84-2, name is Methyl 3-methylpicolinate. This compound has unique chemical properties. The synthetic route is as follows.

A solution of methyl 3-methylpyridine-2-carboxylate (800 mg, 5.29 mmol, 1.00 equiv) and 3-chloroperoxybenzoic acid (1826 mg, 10.58 mmol, 2.00 equiv) in dichloromethane (20 mL) was stirred for 4 hours at 45 C. The resulting solution was concentrated under vacuum and the residue was purified by a silica gel column eluting with ethyl acetate/petroleum ether (1:3). This resulted in the title compound (850 mg, 96%) as yellow oil. LC-MS (ES, mlz): 168 [M+H]+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59718-84-2, Methyl 3-methylpicolinate.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; LIN, Xingyu; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25026; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about Methyl 3-methylpicolinate

Statistics shows that 59718-84-2 is playing an increasingly important role. we look forward to future research findings about Methyl 3-methylpicolinate.

Application of 59718-84-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59718-84-2, name is Methyl 3-methylpicolinate, molecular formula is C8H9NO2, molecular weight is 151.16, as common compound, the synthetic route is as follows.

5 g quantity of methyl 3- [2- (3-benzyloxy-4-methoxy phenyl) oxazol-4-yl] propionate obtained in Reference Example 48 and 3.2 g of methyl 3-methylpicolinate were dissolved in 150 ml of dimethoxyethane. While stirring the solution with ice cooling 1.2 g of sodium hydride was added thereto and further stirred. The reaction mixture was heated and refluxed for 4 hours. At the completion of the reaction, a saturated aqueous ammonium chloride solution was added to the mixture while stirring with ice cooling, and the mixture was further stirred. After stirring the reaction mixture for 30 minutes, water was added thereto and ethyl acetate extraction was performed. The organic layer was washed twice with water, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n- hexane: ethyl acetate = 2:1), thereby yielding 5.5 g of colorless oily substance methyl 2- [2- (3-benzyloxy-4-methoxyphenyl) oxazol-4- ylmethyl] -3- (3-methylpyridin-2-yl) -3-oxopropionate. 1H-NMR (CDCl3) delta: 8.49 (IH, dd, J = 4.8, 1.2 Hz), 7.59-7.28 (1OH, m), 6.91 (IH, d, J = 9.0 Hz), 5.23-5.16 (3H, m) , 3.91 (3H, s) , 3.65 (3H, s), 3.37-3.18 (2H,m,) 2.59 (3H, s)

Statistics shows that 59718-84-2 is playing an increasingly important role. we look forward to future research findings about Methyl 3-methylpicolinate.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; WO2007/58338; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem