Category: 60010-03-9

Reference of 60010-03-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60010-03-9, name is 2,6-Dichloro-4-methyl-3-nitropyridine, molecular formula is C6H4Cl2N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2,6-Dichloro-4-methyl-3-nitropyridine (Step 31.1;1.17 g, 5.68 mmol) was added at rtto a 2M solution of methylamine in THF and alowed to stir for 30 mm. The reaction mixture was then diluted with EtOAc/water, extracted twice with EtOAc and the combined organic extracts were washed with brine, dried (Na2504) and concentrated. The crude product was purified by flash chromatography (ISCO combi flash; EtOAc/hexanes: 1:4, 5i02) to afford the title compound as a yellow solid. tR: 1.08 mm (LC-MS 2); ESl-MS: 202.0 [M+H]1H NMR (400 MHz, DMSO-d6) 0 ppm 2.39 (5, 3 H) 2.90 (d, J=4.65 Hz, 3 H) 6.73 (5, 1 H) 7.95 (d, J=3.91 Hz, 1 H).

According to the analysis of related databases, 60010-03-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BLANK, Jutta; BOLD, Guido; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191894; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 60010-03-9 ,Some common heterocyclic compound, 60010-03-9, molecular formula is C6H4Cl2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Methylamine (2M in THF, 1.5 L, 3000 mmol) was added to a solution of 2,6-dichloro-4-methyl-3- nitropyridine (Step 1 of Example 1, 295 g, 1425 mmol) THF (4.5 L) while maintaining the temperature at 20C. The reaction mixture stirred for 2 h at rt, diluted with EtOAc (3 L) andwater (5 L). The organic layer was separated and the aqueous layer was extracted with EtOAc (2 L). The combined organic extracts were washed with brine (5 L), dried (Na2504), filtered and the filtrate was evaporated in vacuo at 30C to afford the title compound (285 g, purity 81%) as yellow crystals. Rt: 1.07 mm (LC-MS 1); MS mlz: 201.0 [M] (LC-MS 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 60010-03-9, 2,6-Dichloro-4-methyl-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; BLANK, Jutta; BOLD, Guido; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUeEGER, Heinrich; VAUPEL, Andrea; WO2015/75665; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem