Category: 60032-57-7

Synthetic Route of 60032-57-7 ,Some common heterocyclic compound, 60032-57-7, molecular formula is C7H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: 4-Chlorophenylmagnesium bromide (1.0 M in Et2O; 11.0 mL, 11.0 mmol) was added dropwise to a stirred solution of 2-chloronicotinaldehyde 2b (1.42 g, 10.0 mmol) in dry THF (50 mL) under a nitrogen atmosphere at ambient temperature. After 30 minutes, the reaction was quenched by the addition of saturated ammonium chloride (aq; 100 mL). The product was extracted with EtOAc (2 × 100 mL) and the extracts washed with brine (100 mL), combined and dried (MgSO4). The crude product was recrystallised from hot 5% EtOAc-hexane to give the alcohol 5a (1.99 g, 78%) as a white crystalline solid, mp 102 – 103 C. Identical in all other ways to that described above (General Procedure C).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60032-57-7, its application will become more common.

Reference:
Article; Roughley, Stephen D.; Browne, Helen; MacIas, Alba T.; Benwell, Karen; Brooks, Teresa; D’Alessandro, Jalanie; Daniels, Zoe; Dugdale, Sarah; Francis, Geraint; Gibbons, Ben; Hart, Terance; Haymes, Timothy; Kennett, Guy; Lightowler, Sean; Matassova, Natalia; Mansell, Howard; Merrett, Angela; Misra, Anil; Padfield, Anthony; Parsons, Rachel; Pratt, Robert; Robertson, Alan; Simmonite, Heather; Tan, Kiri; Walls, Steven B.; Wong, Melanie; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 901 – 906;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 60032-57-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60032-57-7, name is 2-Methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

(b) methyl 2-Q -(hydroxy(2-methyipyridin-3-yl)mnethyi)bcnzofuran-5-yl)acctate: To asohLtion of methyl 2-(Z-bromobenzofuran-5-yi)acctate (0.35 g, 1.3 mmol) in dry THE (5 niL) wasadded i-PrMgCI-iithium chloride (1.3 M solution in THF, 1.3 mL, 1.6 nnol) dropwise at 0 C andthe reaction mixture was stilTed for 30 mm maintaining the same temperature. ?To the reaction mixture was added a solution of 2-methylnicotinaldehyde (157 rng, 1.3 mniol) in dry TF1F (5 mL) and the reaction mixture was further stirred for 2 h at 0 C. The reaction mixture was quenched with saturated NH4C1 solution and the organic product was extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under vacuum. The crudeproduct was purified by column chromatography (neutral alumina, eluent 5-10% MeOI-f in CH2C12) to afford the title compound (160 mg, yield 40%) as a yellow viscous liquid. ?H NMR (300 MHz, MeOH-d,) 6 ppm 8.36 – 8.34 (dd, J= 4.9 Hz, 1.6 Hz, IH), 8.01 – 7.97 (dd, J= 7.9 Hz, 1.5 Hz, 1H), 7.447.43 (d,J 1.3 Ffz, 1Ff), 7.37-7.30 (in, 2Ff), 7.18 -7.14 (dd,J 8.4 Ffz, 1.6 Ffz, 1Ff), 6.56 (s, 1ff), 6.08 (s, 1Ff), 3.69 (s, 2Ff), 3.65 (s, 3Ff), 2.52 (s, 3Ff).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60032-57-7, 2-Methylnicotinaldehyde.

Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19626; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 60032-57-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60032-57-7, name is 2-Methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

In accordance with the process of the present invention, the compound represented by the formula V is first obtained by reacting a compound of the formula VI with a compound of the formula VII to give a compound of the formula V, wherein the compound represented by the formula VI (p-bromochlorobenzene) Add to the reactor, in the argon protection, adding anhydrous tetrahydrofuran as a solvent, cooled to -75 C, slowly dropping 1.5 M 2M butyl lithium solution, reaction, 6 hours, adding anhydrous methanol quenched by adding two The organic layer was dried over anhydrous sodium sulfate and dried. After the dried intermediate, palladium acetate and an appropriate amount of anhydrous potassium acetate were directly added. The reaction was continued for 11 hours, followed by spotting. After the completion of the reaction, Dichloromethane extraction, organic layer dried with anhydrous sodium sulfate and dried, with methylene chloride / petroleum ether (volume ratio of 1: 5) through the column, spin-dried 4-azafluorenone

According to the analysis of related databases, 60032-57-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOE Technology Group Co., Ltd; Hefei Xin Sheng Photoelectric Technology Co., Ltd; Chen, Jian; Lu, Xiangwan; Li, bin; Zhu, Tao; Yuan, Huifang; Tang, Wenhao; Fang, Qun; Yin, Haibin; Dong, Anxin; (15 pag.)CN105440024; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 60032-57-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60032-57-7, name is 2-Methylnicotinaldehyde, molecular formula is C7H7NO, molecular weight is 121.14, as common compound, the synthetic route is as follows.

[00348] To a solution of 2-methyl -pyridine 3-carbaldehyde (14) (0.5 g, 4.1 mmol) in pyridine (2.5 mL) was added malonic acid (0.65g, 6.1 mmol) and catalytic piperidine (0.2 mL). The reaction mixture was refluxed at 100 C for 3 h and then concentrated under reduced pressure. The residue was diluted with water and the solid product was filtered to give fE)-3-(2-methylpyridin-3-yl) acrylic acid 15. Yield (0.47 g, 71 %). 1H MR (400 MHz, DMSO-< Patent; KARYOPHARM THERAPEUTICS INC.; BALOGLU, Erkan; SHACHAM, Sharon; SENAPEDIS, William; MCCAULEY, Dilara; LANDESMAN, Yosef; GOLAN, Gali; KALID, Ori; SHECHTER, Sharon; WO2015/42414; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem