Category: 60186-15-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60186-15-4, name is 2,4-Difluoro-5-nitropyridine, the common compound, a new synthetic route is introduced below. SDS of cas: 60186-15-4

4-(2-Fluoro-5-nitropyridin-4-yl)morpholine. In a 50 mL round-bottom flask vial was dissolved 2,4-difluoro-5-nitropyridine (175.7 mg, 1.098 mmol) in tetrahydrofuran (5 mL) to give a tan solution. After cooling to -40C, morpholine (0.080 mL, 0.918 mmol) was added, followed by Et3N (0.256 mL, 1.83 mmol). The cloudy yellow mixture was stirred at-40 C – 0C for 3 h. The mixture was concentrated togive a yellow solid. The solid was purified by flash column chromatography on silica gel, eluting with 60% ethyl acetate/hexane, to afford the desired product (209 mg, 100%) as a yellow solid: 1H NMR (400 MHz, Chloroform- d) delta 8.60 (s, 1H), 6.42 (s, 1H), 3.96 – 3.81 (m, 4H), 3.33 – 3.18 (m, 4H);19F NMR (376 MHz, Chloroform-d) delta -61.42.

The synthetic route of 60186-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 60186-15-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60186-15-4, name is 2,4-Difluoro-5-nitropyridine, molecular formula is C5H2F2N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2,4-difluoro-5-nitropyridine (335 mg, 2.093 mmol) in THF (10 mL) at – 40C, was added via cannula 2-methylmorpholine (80 mg, 0.791 mmol) dissolved in THF (1 mL) followed by Et3N (0.583 mL, 4.19 mmol). The cloudy yellow mixture was stirred at -40 C for 1 h and was allowed to warm to 0C. After stirring an additional 2 h, TLC (50% ethyl acetate in hexanes) showed a more polar spot with a small amount of starting material remaining. The mixture was concentrated. The product was purified by column chromatography on silica gel (20%? 50% ethyl acetate in hexanes; 25 g column) to afford 4-(2-fluoro-5-nitropyridin-4-yl)-2-methylmorpholine (264 mg, 1.094 mmol, 52% yield) as a yellow oil: NMR (400MHz, CDCh) delta 8.63 (s, 1H), 6.42 (s, 1H), 4.04 – 3.95 (m, 1H), 3.89 – 3.76 (m, 2H), 3.26 – 3.17 (m, 3H), 2.87 (dd, J=12.8, 10.0 Hz, 1H), 1.24 (d, J=6.3 Hz, 3H); 19 F NMR (376MHz, CDCh) delta -61.49 (s, IF); LC/MS (ESI) m/e 242.1 [(M+H)+, calcd for C10H13FN3O3 242.1].

According to the analysis of related databases, 60186-15-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARTZ, Richard A.; AHUJA, Vijay T.; SIVAPRAKASAM, Prasanna; DUBOWCHIK, Gene M.; MACOR, John E.; (104 pag.)WO2018/98411; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60186-15-4, name is 2,4-Difluoro-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2F2N2O2

2-Fluoro-5-nitro-4-(2,2,2-trifluoroethoxy)pyridine.A solution of 2,4-difluoro-5- nitropyridine (0.1523 g, 0.951 mmol) intetrahydrofuran (2 mL) was cooled to 0 C. 2,2,2-Trifluoroethanol (0.082mL, 1.142 mmol) was added to the mixture. After 5 min, triethylamine (0.265 mL,1.903 mmol) was added. The reaction was stirred at 0 C for 1 h, and thenallowed to warm to rt. The reaction was stirred at rt for 4.5 h. The solventwas removed in vacuo and the crude product carried on without furtherpurification.

With the rapid development of chemical substances, we look forward to future research findings about 60186-15-4.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60186-15-4, name is 2,4-Difluoro-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2F2N2O2

2-Fluoro-5-nitro-4-(2,2,2-trifluoroethoxy)pyridine.A solution of 2,4-difluoro-5- nitropyridine (0.1523 g, 0.951 mmol) intetrahydrofuran (2 mL) was cooled to 0 C. 2,2,2-Trifluoroethanol (0.082mL, 1.142 mmol) was added to the mixture. After 5 min, triethylamine (0.265 mL,1.903 mmol) was added. The reaction was stirred at 0 C for 1 h, and thenallowed to warm to rt. The reaction was stirred at rt for 4.5 h. The solventwas removed in vacuo and the crude product carried on without furtherpurification.

With the rapid development of chemical substances, we look forward to future research findings about 60186-15-4.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60186-15-4, name is 2,4-Difluoro-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2F2N2O2

2-Fluoro-5-nitro-4-(2,2,2-trifluoroethoxy)pyridine.A solution of 2,4-difluoro-5- nitropyridine (0.1523 g, 0.951 mmol) intetrahydrofuran (2 mL) was cooled to 0 C. 2,2,2-Trifluoroethanol (0.082mL, 1.142 mmol) was added to the mixture. After 5 min, triethylamine (0.265 mL,1.903 mmol) was added. The reaction was stirred at 0 C for 1 h, and thenallowed to warm to rt. The reaction was stirred at rt for 4.5 h. The solventwas removed in vacuo and the crude product carried on without furtherpurification.

With the rapid development of chemical substances, we look forward to future research findings about 60186-15-4.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 60186-15-4 , The common heterocyclic compound, 60186-15-4, name is 2,4-Difluoro-5-nitropyridine, molecular formula is C5H2F2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 50 mL round-bottomed flask vial was 2,4-difluoro-5-nitropyridine (263.4 mg, 1.645 mmol) in tetrahydrofuran (8 mL) to give a tan solution. After cooling to -40 C, 2-vinylmorpholine hydrochloride (246 mg, 1.645 mmol) was added, followed by Et3N (0.688 mL, 4.94 mmol). The cloudy tan mixture was stirred at -40 C – 0C for 5 h. TLC (1/2 EtOAc/hexane) showed little SM and one major more polar spot. The mixture was concentrated, and the residue was purified by FCC up to 60% EtOAc/hexane to afford the desired product (348 mg, 84%) as a yellow oil: 1H NMR (400 MHz, Chloroform-d) delta 8.55 (s, 1H), 6.44 (s, 1H), 6.03 – 5.88 (m, 1H), 5.38 – 5.28 (m, 1H), 5.28 – 5.17 (m, 1H), 3.98 – 3.85 (m, 4H), 3.80 (ddd, J = (0086) 11.4, 10.6, 2.8 Hz, 1H), 3.53 (ddd, J = 12.8, 10.6, 3.5 Hz, 1H), 2.95 (dtd, J = 12.9, 2.6, 0.9 Hz, 1H); 19F NMR (376 MHz, Chloroform-d) delta -61.65.

The synthetic route of 60186-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; SIVAPRAKASAM, Prasanna; DUBOWCHIK, Gene M.; MACOR, John E.; (45 pag.)WO2018/98413; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 60186-15-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60186-15-4, name is 2,4-Difluoro-5-nitropyridine. A new synthetic method of this compound is introduced below.

In a 250 mL round-bottomed flask vial was 2,4-difluoro-5-nitropyridine (1.035 g, 6.47 mmol) in tetrahydrofuran (30 mL) to give a tan solution. After cooling to -40 C, 1 -allylpiperazine (0.905 mL, 6.47 mmol) was added, followed by Et3N (1.802 mL, 12.93 mmol). The cloudy tan mixture was stirred at -40 C – -10C for 3 h. TLC (1/1 EtOAc/hexane) showed one major more polar yellow spot. The mixture was concentrated, and the residue was purified by FCC up to 80% EtOAc/hexane to afford the desired product (1.4347 g, 83%) as a yellow solid: 1H NMR (0112) (400 MHz, Chloroform-d) delta 8.58 (s, 1H), 6.41 (s, 1H), 5.97 – 5.77 (m, 1H), 5.31 – 5.1 (m, 2H), 3.33 – 3.23 (m, 4H), 3.09 (dt, J = 6.7, 1.3 Hz, 2H), 2.68 – 2.58 (m, 4H); 19F NMR (376 MHz, Chloroform-d) delta -62.07.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60186-15-4, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; SIVAPRAKASAM, Prasanna; DUBOWCHIK, Gene M.; MACOR, John E.; (45 pag.)WO2018/98413; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60186-15-4, name is 2,4-Difluoro-5-nitropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 2,4-Difluoro-5-nitropyridine

4-(2-Fluoro-5-nitropyridin-4-yl)morpholine. In a 50 mL round-bottom flask vial was dissolved 2,4-difluoro-5-nitropyridine (175.7 mg, 1.098 mmol) in tetrahydrofuran (5 mL) to give a tan solution. After cooling to -40C, morpholine (0.080 mL, 0.918 mmol) was added, followed by Et3N (0.256 mL, 1.83 mmol). The cloudy yellow mixture was stirred at-40 C – 0C for 3 h. The mixture was concentrated togive a yellow solid. The solid was purified by flash column chromatography on silica gel, eluting with 60% ethyl acetate/hexane, to afford the desired product (209 mg, 100%) as a yellow solid: 1H NMR (400 MHz, Chloroform- d) delta 8.60 (s, 1H), 6.42 (s, 1H), 3.96 – 3.81 (m, 4H), 3.33 – 3.18 (m, 4H);19F NMR (376 MHz, Chloroform-d) delta -61.42.

The synthetic route of 60186-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem