Category: 603305-89-1

Adding a certain compound to certain chemical reactions, such as: 603305-89-1, 7-Bromothieno[3,2-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 603305-89-1, blongs to pyridine-derivatives compound. Recommanded Product: 603305-89-1

General procedure: A dry Schlenk tube was charged under Ar with dry toluene (3 mL), the fluoro or methoxyanilines (1.1 equiv.), Pd(OAc)2 (6 mol%), BINAP (8 mol%), Cs2CO3 (2 equiv.) and compound 1. The mixture was heated with stirring under Ar at 100 C for 2 h. After cooling water (5 mL) and ethyl acetate (5 mL) were added. The phases were separated and the aqueous phase was extracted with more ethyl acetate (2 × 5 mL). The organic phase was dried (MgSO4) and filtered. Removal of the solvent gave a solid which was submitted to a dry flash in silica using ether or AcOEt and a solid was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,603305-89-1, its application will become more common.

Reference:
Article; Queiroz, Maria-Joao R.P.; Peixoto, Daniela; Calhelha, Ricardo C.; Soares, Pedro; Dos Santos, Tiago; Lima, Raquel T.; Campos, Joana F.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 855 – 862;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 603305-89-1, name is 7-Bromothieno[3,2-b]pyridine. A new synthetic method of this compound is introduced below., COA of Formula: C7H4BrNS

General procedure: Compound N13z (24.45 mg, 0.118 mmol) in 1,4-dioxane (2 ml) was added Pd2(dba)3 (10.76 mg, 0.012 mmol), XantPhos (13.6 mg, 0.0235 mmol), 4-bromoquinoline (50 mg, 0.118 mmol), and DIPEA (61.4 muL, 0.353 mmol). The reaction vessel was degassed with argon, sealed, and heated to 110 C. overnight. The reaction mixture was then cooled to room temperature, filtered through Celite, and concentrated. The resulting residue was concentrated, diluted with 1:1 acetonitrile and water each containing 0.1% TFA and purified on preparatory HPLC (0 to 100% acetonitrile in water each containing 0.1% TFA). This provided Compound E78a as a TFA salt. LCMS ESI+ calc’d for C29H34N6O2S: 531.3 [M+H+]. found: 531.2 [M+H+].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 603305-89-1, 7-Bromothieno[3,2-b]pyridine.

Reference:
Patent; Gilead Sciences, Inc.; Chin, Gregory; Clarke, Michael O’ Neil Hanrahan; Han, Xiaochun; Hansen, Tim; Hu, Yunfeng Eric; Koltun, Dmitry; McFadden, Ryan; Mish, Michael R.; Parkhill, Eric Q.; Sperandio, David; Xu, Lianhong; Yang, Hai; (199 pag.)US2020/108071; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem