Category: 603310-75-4

Application of 603310-75-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.603310-75-4, name is 5-Isopropylpyridin-2-amine, molecular formula is C8H12N2, molecular weight is 136.1943, as common compound, the synthetic route is as follows.

Step C: Synthesis of 5 2-(5-isopropylpyridin-2-yl)-6-methoxyisoindolin-l-one; NaOEt, EtOH; [0210] A mixture of ethyl 2-(bromomethyl)-5-methoxybenzoate (0.200 g, 0.73 mmol), 5- isopropylpyridin-2-amine (0.118 g, 0.87 mmol) and sodium ethoxide (0.149 g, 2.19 mmol) in ethanol (15 mL) was heated to 120 0C overnight. The mixture was cooled to room temperature and concentrated. The residue obtained was partitioned between water and ethyl acetate. The organic layer was separated, washed with brine solution, dried over sodium sulfate, filtered, and concentrated. Purification by flash chromatography (silica, gradient 0- 20%, ethyl acetate/hexanes) afforded 2-(5-isopropylpyridin-2-yl)-6-methoxyisoindolin-l-one (0.023 g, 9%) as an off-white solid: m.p. 109-110 0C; 1H NMR (500 MHz, CDCl3) delta 8.56 (d, J= 8.6 Hz, IH), 8.25 (d, J= 2.4 Hz, IH ), 7.64 (dd, J= 8.6, 2.4 Hz, IH), 7.43-7.39 (m, 2H), 7.17 (dd, J= 8.3, 2.4 Hz, IH), 5.03 (s, 2H), 3.89 (s, 3H), 2.97-2.92 (m, IH), 1.29 (d, J= 7.0 Hz, 6H); ESI MS m/z 283 [M+ H]+.

The chemical industry reduces the impact on the environment during synthesis 603310-75-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; The United States of America, as represented by the Secretary, Department of Health and Human Services; Science Applications International Corporation (SAIC); Albany Molecular Research, Inc.; WO2009/42907; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.603310-75-4, name is 5-Isopropylpyridin-2-amine, molecular formula is C8H12N2, molecular weight is 136.1943, as common compound, the synthetic route is as follows.Quality Control of 5-Isopropylpyridin-2-amine

General procedure: To the solution of Acid SM-IX (750 mg, 2.i8 mmol, iOO mol-%) in dry DCM (iO ml) under nitrogen atmosphere was added 3-amino-5- methylisoxazole (427 mg, 4.36 mmol, 200 mol-%) and pyridine (526 p1, 6.53mmol, 300 mol-%). T3P (50 w-% in EtOAc) (2.6 ml, 4.36 mmol, 200 mol-%) was added dropwise and the reaction mixture stirred at rt for four hours. DCM (i 0 ml) and i 0 % NaH 003 (30 ml) were added. The water phase was extracted twice with DCM (2 x iO ml). The organic phases were combined and washed with 0.i N HCI solution (3 x 30 ml), water (3 x 30 ml) and finally withbrine (3 x 30 ml) and dried with sodium sulfate. The crude yield of compound i was 95 % (875 mg).1H NMR (200 MHz, DMSO-d6): 0.97 (5, 3 H), i.24 -2.46 (m, i6 H),2.37 (5, 3H), 2.58 – 3.Oi (m, 2 H), 6.64 (5, i H), 6.88-7.06 (m, i H), 7.07 – 7.25 (m, 2 H), iO.88 (5, i H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,603310-75-4, 5-Isopropylpyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; FORENDO PHARMA LTD; HIRVELAe, Leena; HAKOLA, Marjo; LINNANEN, Tero; KOSKIMIES, Pasi; STJERNSCHANTZ, Camilla; (182 pag.)WO2018/224736; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem