Category: 605-38-9

Electric Literature of 605-38-9, Adding some certain compound to certain chemical reactions, such as: 605-38-9, name is Dimethyl pyridine-2,3-dicarboxylate,molecular formula is C9H9NO4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 605-38-9.

80 (33.1 g, 132.8 mmol) and 2,3-pyridine carboxylic acid dimethyl ester (20.2 g, 159.3 mmol) were dissolved in dry THF (1000 mL) and dry methanol (100 mL) in a 3-necked flask with a mechanical stirrer and condenser. To this was added NaH (60percent in mineral oil, 7.01 g, 292.1 mmol) slowly in four portions. The mixture stirred until bubbling ceased, then refluxed for 24 hours. 50 mL 6 M HCl was added to the mixture while in an ice bath, stirring for 15 minutes. 200 mL diethyl ether was added, and the precipitate was filtered, and washed with diethyl ether and H2O , then dried under vacuum at 100° C. with no further purification to afford the desired product 81 (23.7 g, 50percent) as a solid: 300 MHz 1H NMR (CD3SOCD3) delta 9.05 (d, 1H), 8.75 (d, 1H), 7.8 (dd, 1H), 7.95 (d, 1H), 6.55 (s,1H), 6.45 (d, 1H), 4.65 (s, 2H), 3.8 (s, 3H), 3.7 (s, 3H); MS: 381 (M+1).

According to the analysis of related databases, 605-38-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GILEAD SCIENCES, INC.; US2007/72831; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 605-38-9, Adding some certain compound to certain chemical reactions, such as: 605-38-9, name is Dimethyl pyridine-2,3-dicarboxylate,molecular formula is C9H9NO4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 605-38-9.

Preparation of the starting substance: STR28 A solution of 19.5 g (0.1 mole) of 2,3-dimethoxycarbonyl-pyridine and 12 g (0.1 mole) of acetophenone in 300 ml of toluene is added dropwise to a suspension of 2.4 g (0.1 mole) of sodium hydride in 100 ml of toluene, while stirring. The mixture is then boiled under reflux for 3 hours, during which the methyl alcohol formed and about half of the toluene are distilled off. The residue which remains is poured onto a mixture of 15 g of ice and 7.2 g of acetic acid. The organic phase is separated off, the aqueous phase is extracted with chloroform (3 portions of 100 ml each) and the organic phases are combined, dried over sodium sulphate and evaporated in vacuo. The residue is fractionated over silica gel with chloroform as the mobile phase and chromatographed and the corresponding fractions are recrystallized from legroin. 17 g (60percent of theory) of 2-(1,3-dioxo-3-phenyl-prop-1-yl)-3-methoxycarbonyl-pyridine are obtained as white crystals of melting point 87° C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 605-38-9, Dimethyl pyridine-2,3-dicarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; US4752324; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 605-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 605-38-9, name is Dimethyl pyridine-2,3-dicarboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Step b: d,l-cis-Piperidine-2,3-dicarboxylic acid, dimethyl ester Dissolve pyridine-2,3-dicarboxylic acid, dimethyl ester (19 g) in methanol (500 mL) and treat with 20percent palladium hydroxide/carbon (1.5 g). Place on a Paar Hydrogenation Apparatus and hydrogenate at 50 psi for 6 hours. Filter and evaporate the solvent in vacuo to give the title compound (14 g). 1 H NMR (300 MHz, CDCl3) ppm 3.76 (s,3), 3.70 (s,3), 3.66 (d, 1), 3.06 (m, 1), 2.99 (m, 1), 2.7 (m, 1), 2.24-2.1 (m, 2), 1.79 (m, 1), 1.5 (m, 2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 605-38-9, Dimethyl pyridine-2,3-dicarboxylate.

Reference:
Patent; Merrell Dow Pharmaceuticals Inc.; US5194430; (1993); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

605-38-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 605-38-9, name is Dimethyl pyridine-2,3-dicarboxylate. A new synthetic method of this compound is introduced below.

To the solution of dimethyl pyridine-2,3-dicarboxylate (32 g, 164 mmol) in EtOH/H2O (10:1, 440 mL) was added NaBH4 (32 g, 842 mmol) portionwise over 30 min, and the mixture stirred at r.t. overnight. Acetone and EtOAc were added, and the mixture was filtered through a silica gel pad, and evaporated under vacuum to give a yellow solid. This was dissolved in EtOAc/MeOH (5:1), passed through a silica gel pad, and evaporated to give pyridine-2,3-diyldimethanol as a yellow solid. Yield 3.2 g, 14percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,605-38-9, Dimethyl pyridine-2,3-dicarboxylate, and friends who are interested can also refer to it.

Reference:
Patent; MICURX PHARMACEUTICALS, INC.; WO2008/108988; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem