Category: 607373-83-1

Related Products of 607373-83-1 , The common heterocyclic compound, 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine, molecular formula is C6H5ClN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a suspension of 2-chloro-4-methoxy-5-nitropyridine (300 mg, 1.59 mmol), prepared according to a literature procedure (PCT Int. Appl. (2003), WO 2003080610 Al 20031002) in EtOH (3 mL) was added SnCl2.2H20 (1.44g, 6.36 mmol) and the the mixture heated at 90C for lhr. The solvents were evaporated and the residue partitioned between 3M NaOH (50 mL) and DCM (lOOmL). The phases were separated and the organic phase was washed with brine (20 mL), dried (Na2SC>4), the mixture filtered and the filtrate evaporated to dryness to afford the title compound as a yellow oil (174 mg, 69%); m z=158.9, 160.8 (MH)+.

The synthetic route of 607373-83-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H5ClN2O3

Under nitrogen, Example 23B (70 mg, 0.42 mmol), 2-chloro-4-methoxy-5-nitropyridine (94 mg, 0.5 mmol), Pd2 (dba)3 (38 mg , 0.04 mmol), Xantphos (24 mg, 0.04 mmol) and cesium carbonate (271 mg, 0.83 mmol) in dioxane (5mL) were stirred at 90 deg.C for 12 hours. LCMS showed the reaction was complete. After the reaction mixture was diluted with water (40mL) (50mL × 2) and extracted with dichloromethane. The organic layer was washed with brine (30mL × 2), dried over anhydrous sodium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column (petroleum ether: ethyl acetate = 4: 1, 3: 1) to give the title compound (50mg, yield 37.5%) as a yellow oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 607373-83-1, 2-Chloro-4-methoxy-5-nitropyridine.

Reference:
Patent; Nanjing Mingde New Drug Research and Development Co. Ltd.; Qilu Pharmaceutical Co., Ltd.; Ding, Zhaozhong; Zhang, Minghui; Chen, Shuhui; Liu, Xile; Zhu, Yidong; Fan, Chuanwen; Zhao, Baoping; Zhang, Long; Chen, Dong; Yang, Yingying; Zheng, Qingmei; Zheng, Shansong; Wan, Haiwen; Hu, Jinqing; (93 pag.)CN105330698; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine, molecular formula is C6H5ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 607373-83-1

To a solution of 2-chloro-4-methoxy-5-nitro-pyridine (26 mmol) in dry THF (50 mL) at room temperature was added methyl amine (25 mL) (2M in THF). The mixture was allowed to stir for a further 2 h at room temperature. After completion of reaction as seen by TLC and LCMS, solvent was evaporated under reduced pressure to give 5 g of desired Intermediate 1. [00260] ‘H-NMR (400 MHz, DMSO-i: delta 2.95 (d, 3H), 7.01 (s, 1H), 8.57 (bs, 1H), 8.86, 1H). [00261] Mass (M+l): m/z 188.

With the rapid development of chemical substances, we look forward to future research findings about 607373-83-1.

Reference:
Patent; GALAPAGOS NV; MENET, Christel; SCHMITT, Benoit; GENEY, Raphael; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James; WO2013/117649; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 607373-83-1 ,Some common heterocyclic compound, 607373-83-1, molecular formula is C6H5ClN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 2-chloro-4-methoxy-5-nitropyridine (9.4 g, 50 mmol) and methylamine (35 wt.% in EtOH) (47 mL, 500 mmol) was stirred at 150C (microwave) for 15 min. The reaction mixture was allowed to cool to room temperature. Water (50 mL) was added. The resultant solid material was collected by filtration, washed with MeOH and then Et20 and dried in vacuo to give the desired compound. lH NMR delta (ppm)(CDCl3): 8.94 (1 H, s, ArH), 8.20 (1 H, s, NH), 5.33 (1 H, s, ArH), 5.24 (1 H, s, NH), 3.00 (3 H, d, CH3), 2.97 (3 H, d, CH3). LCMS (15cm_Formic_Ascemtis_HPLC_MeCN) Rt 6.24 (min) m/z 183 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 607373-83-1, 2-Chloro-4-methoxy-5-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoit Antoine; GENEY, Raphael Jean Joel; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart; WO2013/117645; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 607373-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

2-chloro-4-methoxy-5-nitropyridine (0.6 g, 3.19 mmol), thiophene-2-boronic acid (0.45 g, 3.5 mmol), [l,l ‘-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.26 g, 0.32 mmol) and cesium carbonate (1.55 g, 4.8 mmol) in DMF (12 mL) were stirred and heated in a sealed tube at 90C for 18h. The reaction mixture was cooled to room temperature, filtered through Celite and washed through with DCM. The filtrate was washed with water, dried (hydrophobic frit) and concentrated in vacuo. The residue was purified by column chromatography using silica gel and eluting with EtOAc in hexane (0-30%) to give the desired compound.

According to the analysis of related databases, 607373-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoit Antoine; GENEY, Raphael Jean Joel; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart; WO2013/117645; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Chloro-4-methoxy-5-nitropyridine

A mixture of 2-chloro-4-methoxy-5-nitropyridine (208 mg, 1.10 mmol), ammonium chloride (295 mg, 5.52 mmol) and iron powder (246mg, 4.4immol) in ethanol (5mL) and water (0.5mL) was heated at 80 oC for 18 h. The mixture was cooled and filtered through a Celite cartridge and washed through with methanol. The combined filtrate and washing was evaporated, and the residue partitioned between DCM (10 mL)and water (10 mL), the organic phase was washed further with water (10 mL), and the aqueous washes were combined and extracted with DCM (3 x 5 mL). The organic extracts were combined and filtered through a hydrophobic fit, and the solvent was removed by evaporation to give the product as an off-white solid (155 mg, 89%). ?H NMR (400 MHz, CDC13): oe 7.73 (s, 1H); 6.71 (s, 1H); 3.90 (s, 3 H); 3.71 (s, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 607373-83-1, 2-Chloro-4-methoxy-5-nitropyridine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; CHAMBERS, Mark; CHAN, Bryan K.; ESTRADA, Anthony; SWEENEY, Zachary Kevin; WO2013/79495; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem