Category: 60753-14-2

Synthetic Route of 60753-14-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60753-14-2, name is 4-(Pyridin-3-yl)butan-1-ol, molecular formula is C9H13NO, molecular weight is 151.21, as common compound, the synthetic route is as follows.

EXAMPLE 122 Preparation of alpha-oxo-4-[4-(3-pyridinyl)butoxy]benzeneacetic acid methyl ester (4:1) molar hydrate A stirred mixture of 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester (1.14 g), 3-pyridinebutanol (1.04 g), triphenylphosphine (2.07 g), and tetrahydrofuran (25 mL) was stirred at 0 C. while adding dropwise a solution of diethyl azodicarboxylate (1.37 g) in tetrahydrofuran (10 mL). The mixture was stirred for 2 hours at 0 C. and evaporated to dryness. The material was purified by HPLC (hexane-acetone; 2:1) to provide 1.4 g of alpha-oxo-4-[4-(3-pyridinyl)butoxy]benzeneacetic acid methyl ester (4:1) molar hydrate as a colorless oil. Analysis Calculated for C18 H19 NO4.4:1H2 O: C, 68.02; H, 6.18; N, 4.41. Found: C, 68.24; H, 6.19; N, 4.68.

The chemical industry reduces the impact on the environment during synthesis 60753-14-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hoffman-La Roche Inc.; US5344843; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 60753-14-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60753-14-2, name is 4-(Pyridin-3-yl)butan-1-ol, molecular formula is C9H13NO, molecular weight is 151.21, as common compound, the synthetic route is as follows.

EXAMPLE 122 Preparation of alpha-oxo-4-[4-(3-pyridinyl)butoxy]benzeneacetic acid methyl ester (4:1) molar hydrate A stirred mixture of 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester (1.14 g), 3-pyridinebutanol (1.04 g), triphenylphosphine (2.07 g), and tetrahydrofuran (25 mL) was stirred at 0 C. while adding dropwise a solution of diethyl azodicarboxylate (1.37 g) in tetrahydrofuran (10 mL). The mixture was stirred for 2 hours at 0 C. and evaporated to dryness. The material was purified by HPLC (hexane-acetone; 2:1) to provide 1.4 g of alpha-oxo-4-[4-(3-pyridinyl)butoxy]benzeneacetic acid methyl ester (4:1) molar hydrate as a colorless oil. Analysis Calculated for C18 H19 NO4.4:1H2 O: C, 68.02; H, 6.18; N, 4.41. Found: C, 68.24; H, 6.19; N, 4.68.

The chemical industry reduces the impact on the environment during synthesis 60753-14-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hoffman-La Roche Inc.; US5344843; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 60753-14-2, 4-(Pyridin-3-yl)butan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H13NO, blongs to pyridine-derivatives compound. HPLC of Formula: C9H13NO

Step A 4-pyridin-3-yl-butyraldehyde To a solution of oxalyl chloride (0.74 mL in 5 mL dry methylene chloride) at -78 C. was added a solution of methyl sulfoxide (0.90 mL in 5 mL methylene chloride) and the mixture stirred at low temperature for 15 minutes. A solution of 4-pyridin-3-yl-butan-1-ol (prepared essentially as described in Example 2.1, 820 mg in 10 mL methylene chloride) and the reaction allowed to proceed for 45 minutes after which time 4 mL triethylamine were added and the mixture allowed to warm to room temperature. After 35 minutes saturated sodium bicarbonate was addded and the mixture extracted with methylene chloride. The organic portion was washed with saturated sodium bicarbonate, dried over sodium sulfate and concentrated in vacuo to give the crude title compound (813 mg).

The synthetic route of 60753-14-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck & Co., Inc.; US5849764; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 60753-14-2 ,Some common heterocyclic compound, 60753-14-2, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 3-(pyridin-4-yl)propan-1-ol (151mg, 1.1mmol), 2-(3-bromophenylthio)pyridine-3-ol (5) (282mg 1.0mmol) and triphenylphosphine (289mg, 1.1mmol) in THF (2.0mL) was added diisopropylazodicarboxylate (222mg 1.1mmol) at 0C and stirred at ambient temperature. After 5h, the mixture was evaporated, diluted with EtOAc (15mL), and extracted with 10% HCl solution (2×15mL). The aqueous phase was then basified to pH 12 with K2CO3 and extracted with EtOAc (2×15mL). The organic phase was washed with brine (2×5mL), dried (Na2SO4), and evaporated in vacuo. The residue was subjected to flash column chromatography (EtOAc-hexane gradient) followed by crystallization (Et2O) to afford title compound 3 as a white crystalline solid (390mg, 97%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60753-14-2, its application will become more common.

Reference:
Article; Kato, Yoshihiro; Kawasaki, Motoji; Nigo, Tomohiro; Nakamura, Shunya; Fusano, Akira; Teranishi, Yasuhiro; Ito, Mari N.; Sumiyoshi, Takaaki; Bioorganic and Medicinal Chemistry; vol. 21; 18; (2013); p. 5851 – 5854;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 60753-14-2 ,Some common heterocyclic compound, 60753-14-2, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 3-(pyridin-4-yl)propan-1-ol (151mg, 1.1mmol), 2-(3-bromophenylthio)pyridine-3-ol (5) (282mg 1.0mmol) and triphenylphosphine (289mg, 1.1mmol) in THF (2.0mL) was added diisopropylazodicarboxylate (222mg 1.1mmol) at 0C and stirred at ambient temperature. After 5h, the mixture was evaporated, diluted with EtOAc (15mL), and extracted with 10% HCl solution (2×15mL). The aqueous phase was then basified to pH 12 with K2CO3 and extracted with EtOAc (2×15mL). The organic phase was washed with brine (2×5mL), dried (Na2SO4), and evaporated in vacuo. The residue was subjected to flash column chromatography (EtOAc-hexane gradient) followed by crystallization (Et2O) to afford title compound 3 as a white crystalline solid (390mg, 97%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60753-14-2, its application will become more common.

Reference:
Article; Kato, Yoshihiro; Kawasaki, Motoji; Nigo, Tomohiro; Nakamura, Shunya; Fusano, Akira; Teranishi, Yasuhiro; Ito, Mari N.; Sumiyoshi, Takaaki; Bioorganic and Medicinal Chemistry; vol. 21; 18; (2013); p. 5851 – 5854;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 60753-14-2 , The common heterocyclic compound, 60753-14-2, name is 4-(Pyridin-3-yl)butan-1-ol, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(a) N-(3-Nicotinylpropyl)benzylamine To a solution of 3-nicotinyl-1-propanol (50.0 g, 365 mmol) and triethylamine (110 g, 1.09 mol) in methylene chloride (500 ml) at 0 C. was added dropwise methanesulfonyl chloride (83.5 g, 7.29 mmol). The solution was stirred at 0 C. for 1 hour and then RT for 1 hour, and the excess of methanesulfonyl chloride was carefully decomposed with ice-water. The organic layer was separated and washed with water (twice). The aqueous layer and washings were combined, basified with 50% aqueous sodium hydroxide, and extracted with methylene chloride (3 times). The methylene chloride extracts were combined, washed with saturated brine solution, dried (MgSO4), and evaporated to give 72.0 g (92% yield) of the mesylate which was used immediately for the further reaction. A solution of the mesylate (72.0 g, 334 mmol) and benzylamine (179.2 g, 1.6 mol) in DMSO (300 ml) was stirred at RT overnight. The reaction mixture was poured into 2 l of water and extracted with ethyl acetate (three times). The extracts were dried with MgSO4, thus yielding 75 g of a red oil after evaporation of benzylamine. The oil was used directly for the next reaction without further purification.

The synthetic route of 60753-14-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fisons Corporation; US4889941; (1989); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 60753-14-2 , The common heterocyclic compound, 60753-14-2, name is 4-(Pyridin-3-yl)butan-1-ol, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

D. 3-[4-[4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-2,6-dimethylphenoxy]-butyl]-pyridine (I, Q=3-pyridyl, Y=1,4-butylene, R1,R2 =3,5-dimethyl, R3 =5-trifluoromethyl-1,2,4-oxadiazol-3-yl) To a suspension of 0.44 g (1.8 mmol) of 4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-2,6-dimethylphenol, 0.25 g (1.66 mmol) of 3-(4-hydroxybutyl)-pyridine, and 0.52 g (1.99 mmol) of triphenylphosphine in 30 ml of methylene chloride under nitrogen at 0 C. was added dropwise a solution of 0.35 g (1.97 mmol of DEAD in methylene chloride, and the resulting mixture was allowed to warm to room temperature. After adding 70 mg of triphenylphosphine, the mixture was stirred at room temperature for 2 days. The solution was concentrated in vacuo and the residue was purifed by MPLC (26 id Kieselgel 60 column; hexane/ethyl acetate 3:1) to yield 0.56 g (86.1%) of 3-[4-[4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-2,6-dimethylphenoxy]-butyl]-pyridine, as a pale yellow oil.

The synthetic route of 60753-14-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanofi, S.A.; US5618821; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 60753-14-2 ,Some common heterocyclic compound, 60753-14-2, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

7.561 g (0.05 mol) of 4-(3-pyridyl)-1-butanol and 19.020 g (0.05 mol) of 1-iodooctadecane were added to a three-necked flask.Add 70 ml of N,N-dimethylformamide,Then at 120 C,Stir the reaction for 12 hours,Cool to room temperature,After the reaction is over,Purifying the reaction product,After completely removing the monomer not involved in the reaction,Vacuum drying to constant weight,getIodinated 1-octadecyl-3-pyridinium butanol quaternary ammonium salt.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 60753-14-2, 4-(Pyridin-3-yl)butan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; South China University of Technology; Liu Fang; He Jingwei; Zhang Yunlong; (13 pag.)CN108484487; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem