Category: 60832-72-6

Related Products of 60832-72-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60832-72-6, name is Oxazolo[4,5-b]pyridin-2(3H)-one. A new synthetic method of this compound is introduced below.

Step-2 [0135] To the stirred solution of compound 2 (0.5 g, 3.35 mmol) in DMF (3 ml) was added bromine (0.53 g, 3.35 mmol) at 0 C. After 2 h stirring at room temperature, reaction mass was poured onto crushed ice, solid was followed out, filtered the solid and dried under vacuum to get the desired compound 3 (0.25 g)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; Rangarajan, Radha; Kumar, Rajinder; Prabhakar, BV; Chandrasekhar, P; Mallikarjuna, P; Banerjee, Ankita; US2014/249170; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H4N2O2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H4N2O2

As shown in step 4-ii of Scheme 4, bromine (10.8 mL, 210.1 mmol) was added dropwise over 20 min to a stirring solution of Compound 1011 (26.0 g, 191 mmol) in DMF (200 mL). The reaction mixture was stirred at RT for 14 h. The mixture was poured onto crushed ice and the precipitate that formed was collected in a fritted funnel. The solid was washed with water (200 mL) and dried under vacuum to afford 6-bromooxazolo[4,5- 6]pyridine-2(JH)-one (Compound 1012, 37.0 g, 91% yield) as a light yellow solid: ESMS (M+Eta) 215, 217; 1H NMR (DMSO-d6) delta 12.6 (br, 1Eta), 8.2 (s, 1Eta), 8.0 (s, 1Eta).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; COME, Jon; COTTRELL, Kevin; GREY, Ronald; LE TIRAN, Amaud; MARONE, Valerie; MARTINEZ-BOTELLA, Gabriel; MESSERSMITH, David; HUCK, Emilie, Porter; WO2010/135014; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 60832-72-6 ,Some common heterocyclic compound, 60832-72-6, molecular formula is C6H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To the stirred solution of compound 2( 0.5 g,3.35 mmol )in DMF ( 3 ml )was added bromine(0.53g, 3.35 mmol ) at 0C.After 2h stirring at room temperature ,reaction mass was poured onto crushed ice, solid was followed out ,filtered the solid and dried under vacuum to get the desired compound 3 ( 0.25 g )

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60832-72-6, its application will become more common.

Reference:
Patent; VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita; WO2013/42035; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60832-72-6, name is Oxazolo[4,5-b]pyridin-2(3H)-one, molecular formula is C6H4N2O2, molecular weight is 136.1082, as common compound, the synthetic route is as follows.Safety of Oxazolo[4,5-b]pyridin-2(3H)-one

To a solution of 3/+oxazolo[4,5-6]pyridin-2-one (13.6 g, 100 mmol) in acetonitrile (600 mL) and acetic acid (120 mL) was added N-bromosuccinimide (21.4 g, 120 mmol). The mixture was stirred at room temperature for 4 hr and the reaction was quenched with Na2S205 solution. After evaporation, the residue was partitioned between ethyl acetate and water. The organic layer was washed with 2N NaOH solution, brine, and dried over Na2S04. The crude product was purified on a silica gel column to provide e-bromo-SAfoxazoloK.S-bJpyridin^-one (11.5 g, 55% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; WO2006/21886; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 60832-72-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60832-72-6, name is Oxazolo[4,5-b]pyridin-2(3H)-one, molecular formula is C6H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 2 DMF was added to a 10L three-neck round bottom flask (2000mL) with reflux condenser on each neck. Oxazole [4,5-b]pyridine-2(3H)-one (497g) was added with mechanical stirring until it was dissolved. N- chlorosuccinimide (608g) was dissolved in DMF (2500mL). Transferred to a pressure-equalizing dropping funnel, N-chlorosuccinimide was slowly added dropwise to the reaction flask, the reaction temperature is controlled not to exceed 40C (cooling with ice-water if necessary). Afterwhich, the ice bath was removed, then stirred at room temperature overnight. The reaction was monitored by TLC and GC. After completion of the reaction, 4000mL water was slowly added under cooling with ice water. The reaction mixture was stirred for 30 minutes and filtered. The filter cake was washed twice with water and dried under vacuum to give crude 530g. The crude product was recrystallized from ethyl acetate and methylene chloride to give pure product 6-chlorooxazole[4,5-b]pyridine-2(3H)-one (505g), yield 81%, purity 99.1% (GC) . Melting point 184C ~ 187C (literature 183C ~ 186C).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one.

Reference:
Patent; Dingtao YOUBANG Chemical Co., Ltd.; Fan, Hongli; Han, Meng; Zhao, Jingtao; Lai, Xinsheng; (5 pag.)CN103755627; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 60832-72-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60832-72-6, name is Oxazolo[4,5-b]pyridin-2(3H)-one, molecular formula is C6H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 2 DMF was added to a 10L three-neck round bottom flask (2000mL) with reflux condenser on each neck. Oxazole [4,5-b]pyridine-2(3H)-one (497g) was added with mechanical stirring until it was dissolved. N- chlorosuccinimide (608g) was dissolved in DMF (2500mL). Transferred to a pressure-equalizing dropping funnel, N-chlorosuccinimide was slowly added dropwise to the reaction flask, the reaction temperature is controlled not to exceed 40C (cooling with ice-water if necessary). Afterwhich, the ice bath was removed, then stirred at room temperature overnight. The reaction was monitored by TLC and GC. After completion of the reaction, 4000mL water was slowly added under cooling with ice water. The reaction mixture was stirred for 30 minutes and filtered. The filter cake was washed twice with water and dried under vacuum to give crude 530g. The crude product was recrystallized from ethyl acetate and methylene chloride to give pure product 6-chlorooxazole[4,5-b]pyridine-2(3H)-one (505g), yield 81%, purity 99.1% (GC) . Melting point 184C ~ 187C (literature 183C ~ 186C).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one.

Reference:
Patent; Dingtao YOUBANG Chemical Co., Ltd.; Fan, Hongli; Han, Meng; Zhao, Jingtao; Lai, Xinsheng; (5 pag.)CN103755627; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60832-72-6, name is Oxazolo[4,5-b]pyridin-2(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 60832-72-6

The synthesis was carried out analogously to the reaction procedure of Example I-1 using: 0.50 g (3.67 mmol) of oxazolo[4,5-b]pyridin-2(3H)-one (cf. WO 2010/135014 A1), 0.82 g (3.67 mmol) of 2-chloro-5-chloromethyl-3-fluoropyridine (DE 102006015468 A1), 1.79 g (5.51 mmol) of cesium carbonate in 50 ml of DMF, 62.5 mg of cesium iodide. [0183] This gives 32.0 mg (3.1% of theory) of 4-(6-chloro-5-fluoropyridin-3-ylmethylloxazolo[4,5-b]pyridin-2(4H)-one. [0184] LC-MS (ESI positive): m/z found: 280.0 [M++H]. [0185] C12H7ClFN3O2 calculated: 279.0. [0186] 1H NMR (600 MHz, DMF-d6) delta 5.73 (s, 2H), 6.99 (t, 1H), 7.47 (dd, 1H), 8.08 (dd, 1H), 8.16 (dd, 1H), 7.56 (d, 1H) ppm [0187] 13C with 1H decoupling (CPD) NMR (150 MHz, DMF-d6) delta 52.4 (CH2), 112.6, 113.3, 145.2, 160.7 (hetaryl-C), 138.5 (Py-CCl), 154.9 (Py-CF), 126.4, 133.3, 146.2 (Py-C), 163.1 (C?O) ppm

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one.

Reference:
Patent; Jeschke, Peter; Schindler, Michael; Woelfel, Katharina; Ebbinghaus-Kintscher, Ulrich; Voerste, Arnd; Malsam, Olga; Losel, Peter; Goergens, Ulrich; US2014/113824; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60832-72-6, name is Oxazolo[4,5-b]pyridin-2(3H)-one, molecular formula is C6H4N2O2, molecular weight is 136.1082, as common compound, the synthetic route is as follows.COA of Formula: C6H4N2O2

Preparation 7 6-BROMO-3H-OXAZOLO[4,5-b]-PYRIDIN-2-ONE 0.01 mol of oxazolo[4,5-b]pyridin-2-one is dissolved in 100 ml of dimethylformamide. 0.011 mol of bromine is added via a dropping funnel. Stirring is maintained for 1 hour 30 minutes at room temperature and an ice/water mixture is added. The product is filtered off. It is washed with water. The product is dried. Yield: 90%. Melting point: 234 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; Science et Organisation; US5084456; (1992); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 60832-72-6, blongs to pyridine-derivatives compound. Recommanded Product: 60832-72-6

To a stirred suspension of [1 ,3]oxazolo[4,5-o]pyridin-2(3H)-one (1-51) (34 g, 0.25 mol) in MeCN (0.35 L) was added NBS (47.6 g, 0.275 mol) in a portionwise manner at 0 C. After addition, the reaction mixture was stirred at room temperature for 3 h. TLC (EtOAc/hexane = 1 :1) indicated the reaction was complete. The precipitate was filtered, washed with cold MeCN (150 ml_) and dried under vacuum to yleld 6-bromo[1 ,3]oxazolo[4,5-o]pyridin-2(3H)-one (I-52) (45 g, 84%) as a yellow solid, which was used directly in the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60832-72-6, its application will become more common.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 60832-72-6, Oxazolo[4,5-b]pyridin-2(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 60832-72-6, blongs to pyridine-derivatives compound. Recommanded Product: 60832-72-6

To a stirred suspension of [1 ,3]oxazolo[4,5-o]pyridin-2(3H)-one (1-51) (34 g, 0.25 mol) in MeCN (0.35 L) was added NBS (47.6 g, 0.275 mol) in a portionwise manner at 0 C. After addition, the reaction mixture was stirred at room temperature for 3 h. TLC (EtOAc/hexane = 1 :1) indicated the reaction was complete. The precipitate was filtered, washed with cold MeCN (150 ml_) and dried under vacuum to yleld 6-bromo[1 ,3]oxazolo[4,5-o]pyridin-2(3H)-one (I-52) (45 g, 84%) as a yellow solid, which was used directly in the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60832-72-6, its application will become more common.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem