Category: 609-71-2

Application of 609-71-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 2-hydroxynicotinic acid (3.6 mmol) in sulfuric acid (30% free S03, 2 ml) was added sodium nitrate (7.2 mmol) portionwise over 20 min. The solution was allowed to stir for 20 h at room temperature. The solution was then poured onto ice-water and the precipitate that formed was filtered off, washed with water and dried in a vacuum oven to afford a pale yellow solid (45%). (0176) ESIMS: M-l: 183 (0177) 1H NMR (300 MHz, DMSO) d 8.94 (1H, d, H-4), 8.67 (1H, d, H-6).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.

Reference:
Patent; BIONOMICS LIMITED; O’CONNOR, Sue; RATHJEN, Deborah; (55 pag.)WO2019/109150; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 609-71-2, Adding some certain compound to certain chemical reactions, such as: 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid,molecular formula is C6H5NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 609-71-2.

A stirred suspension of NaH 60% dispersion in mineral oil (206 mg, 5.14 mmol), washed twice with distilled n-hexane and once with Et20 in 2 mL of anhydrous DMF under N2 atmosphere was treated dropwise with a solution containing the 2-hydroxynicotinic acid (600 mg, 4.31 mmol) in 5 mL of anhydrous DMF. The mixture was left under stirring at room temperature for 2h and then 3,4-difluoro-benzylbromide (1.06 g, 5.14 mmol) was added and the mixture stirred and heated at 50C for 1 6h. After the mixture was concentrated under reduced pressure and the residue was treated with water to give a solid, which was collected by vacuum filtration. Next the solid was refluxed for 4h in aq. 10% NaOH (10 mL) and the resulting mixture was cooled and made acid with 1 N aq.HCI. The white solid formed was collected by filtration and washed with nhexane and Et20, giving the derivative 3.9 as white solid (857 mg, 3.23 mmol, 75% yield).1HNMR (400 MHz, DMSO-d6): 65.30 (5, 2H, CH2); 6.78 (t, 1H, J = 6.9 Hz, Ar);7.22-7.24 (m, 1H, Ar); 7.41 -7.53 (m, 2H, Ar); 8.41 (d, 2H, J = 6.9 Hz, Ar) ppm.Anal. Calcd for C13H9NO3F2: C, 58,87%; H, 3.42%; N, 5.28%; Found: C, 58,99%; H, 3.47%; N, 5.43%

According to the analysis of related databases, 609-71-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.; SESTITO, Simona; DANIELE, Simona; MARTINI, Claudia; RAPPOSELLI, Simona; PURICELLI, Guido; (63 pag.)WO2016/198597; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 609-71-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of the chlorophosphite (10) (1.121 g; 0.936 mmol) in toluene (7 ml) is added dropwise at 0 C. while stirring a solution of 2-hydroxynicotinic acid (0.506 g; 3.742 mmol) in a mixture of toluene (13 ml) and triethylamine (5.6 ml). The mixture is stirred at room temperature overnight and filtered, and the filtrate is concentrated under reduced pressure. The residue obtained is dried at 50 C./0. 1 mbar for 2 h and is used as obtained. Yield: 0.67 g (0.458 mmol; 49%).10117] Analysis (calc. for C74H74N4020P4=1463.30 g/mol): C, 60.92 (60.74) %; H, 5.02 (5.10) %; P, 8.57 (8.47)j0118] 31P-NMR (CD2C12): 115.1 (s) ppm. ?H-NMR (CD2C12): 1.18 (36H); 1.84 (6H); 3.08 (4H); 3.85 (4H); 7.008.63 (24H) ppm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.

Reference:
Patent; EVONIK DEGUSSA GMBH; DYBALLA, Katrin Marie; FRANKE, Robert; (21 pag.)US2017/88569; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 609-71-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below.

Step 1 Methyl 2-hydroxynicotinate 2-Hydroxynicotinic acid (2.50 g, 17.97 mmol) was dissolved in methanol (20.00 mL), added with sulfuric acid (18M, 47.90 uL), and then stirred at 70 C. under nitrogen atmosphere for 12 hours. After the reaction mixture was concentrated, the residue was dissolved in dichloromethane (50.00 mL) and the system was adjusted to pH=8 with saturated sodium bicarbonate solution. A white solid was slowly precipitated and filtered to give methyl 2-hydroxynicotinate (a white solid, 1.5 g, yield: 54.51%). 1H NMR (400 MHz, CDCl3) 8.27 (dd, J=2.0, 7.0 Hz, 1H), 7.78 (dd, J=2.0, 6.0 Hz, 1H), 6.41 (t, J=6.8 Hz, 1H), 3.90 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Heilongjiang Zhenbaodao Pharmaceutical Co., Ltd.; MEDSHINE DISCOVERY INC.; HE, Haiying; JIANG, Zhigan; XIA, Jianhua; WANG, Jing; HAN, Lixia; LAN, Lihong; ZHOU, Hui; LAI, Kunmin; CHEN, Shuhui; US2018/346438; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below., Quality Control of 2-Oxo-1,2-dihydropyridine-3-carboxylic acid

To a solution of 2-hydroxynicotinic acid 1 (18.98 g, 0.136 mmol) in glacial acetic acid was added bromine (8.4 ml, 0.163 mmol). The reaction mixture was stirred at 80 C overnight and monitored by TLC to confirm its completion. The reaction mixture was then evaporated in vacuo and the resulted precipitate was collected, washed with cold water and filtered to furnish the compound 2 in good yields. (22.7, 76.6%). 1H-NMR (300 MHz, CDCl3) delta 8.25 (d, J = 2.4 Hz, 1H), 8.34 (d, J = 2.4 Hz, 1H), 13.8 (brs, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.

Reference:
Article; Liu, Linyi; Li, Xinyu; Cheng, Yu; Wang, Lianjian; Yang, Huizhu; Li, Jiurong; He, Siying; shuangjie Wu; Yin, Qianqian; Xiang, Hua; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 304 – 316;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, molecular weight is 139.1088, as common compound, the synthetic route is as follows.COA of Formula: C6H5NO3

Preparation 49 5-Bromo-2-hydroxy-3-pyridinecarboxylic acid To a solution of 10 g (0.07 mole) of 2-hydroxy-nicotinic acid in 16.8 g of 50% sodium hydroxide (0.21 mole) diluted with 25 ml of water was added 200 ml of sodium hypobromite solution prepared by adding 13.6 g (0.17 mole) of bromine to a solution of 20.16 g of 50% sodium hydroxide (0.25 mole) in 125 ml of water at 0 C. diluted to 400 ml. After 24 hrs of stirring at room temperature, another 100 ml portion of the above sodium hypobromite solution was added and the reaction solution was stirred for another 24 hr. The reaction solution was cooled in an ice bath and acidified carefully with 12N hydrochloric acid. Crystallization from isopropyl alcohol gave 9.7 g (63.5%) of product. A sample was further recrystallized from 95% ethanol, m.p. 245 C. Analysis: Calculated for C6 H4 NO3: C, 33.06; H, 1.85; N, 6.42. Found: C, 32.98; H, 1.83; N, 6.44.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; A. H. Robins Company, Inc.; US4592866; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 609-71-2 ,Some common heterocyclic compound, 609-71-2, molecular formula is C6H5NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 155A 1-butyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid To a solution of 2-hydroxy-nicotinic acid (0.50 g, 3.59 mmol) and potassium hydroxide (0.40 g, 7.13 mmol) in 4:1 methanol: water (6 mL) at room temperature, was added 1-iodobutane (0.74 mL, 6.42 mmol). This solution was heated at 60 C. for 30 minutes, then cooled to room temperature and diluted with water and 1N HCl. The resulting solid was filtered and dried to give the title compound (0.27 g, 39%). MS (DCI/NH3) m/z 196 (M+H)+; 1H NMR (300 MHz, DMSO-d6) delta 0.91 (m, 3H) 1.30 (m, 2H) 1.69 (m, 2H) 4.10 (m, 2H) 6.73 (m, 1H) 8.27 (dd, J=6.62, 1.84 Hz, 1H) 8.38 (dd, J=7.35, 2.21 Hz, 1H) 14.68 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pratt, John K.; Betebenner, David A.; Donner, Pamela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong; US2004/162285; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 609-71-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, molecular weight is 139.1088, as common compound, the synthetic route is as follows.

2-Hydroxynicotinic acid (4 g, 17.97 mmol) was suspended indichloromethane (115 mL) and DMF (1.15 mL) and then oxalylchloride (2M in CH2Cl2 solution, 3 eq, 43 mL) was added slowlyunder Ar flow (gas evolved). The mixture was stirred at rt tillcompletion of reaction by LC-MS, 4 h. The reaction mixture wasconcentrated under vacuum and further dried in vacuum pump.The crude product, 2-chloronicotinoyl chloride, was used in nextstep assuming quantitative yield. A suspension of 2-chloronicotinoyl chloride (3.16 g, 17.95 mmol) in THF (72 mL) wasadded to a mixture of 2-amino-5-nitrophenol (1.15 eq, 3.18 g) andDIPEA (1.7 eq, 5.3 mL) in THF (72 mL) at 0 C. The reaction mixturewas stirred at 0 C for 2 h and then allowed to get rt. The solids insuspension were filtered out and washed with ethyl acetate. Thefiltrate was washed with water and brine. The organic layer wasdried (Na2SO4) and concentrated to render a solid that was trituratedwith CH2Cl2 affording 3 (brownish solid, 3.76 g, 70%); 1H NMR(700 MHz, DMSO) d 8.68 (dd, J 4.7, 2.0 Hz, 1H), 8.64 (m, 1H), 8.10(d, J 2.5 Hz, 1H), 7.97 (dd, J 9.1, 2.5 Hz, 1H), 7.67 (m, 1H), 6.85 (m,3H). LCMS (ESI): m/z 212 [M H]; Rt: 4.05 min.

Statistics shows that 609-71-2 is playing an increasingly important role. we look forward to future research findings about 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.

Reference:
Article; Albarran, M. Isabel; Amezquita-Alves, Adrian; Blanco-Aparicio, Carmen; Cebria, Antonio; Garcia, Ana Belen; Garcia-Campos, Francisco Javier; Martinez-Gago, Jaime; Martinez-Gonzalez, Sonia; Martinez-Torrecuadrada, Jorge; Munoz, Ines; Pastor, Joaquin; European Journal of Medicinal Chemistry; vol. 201; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 609-71-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(d) 5- Bromo-2-hydroxy-nicotinic acid To a suspension of 5.0 g (35.9 mmol) of 2-hydroxy-nicotinic acid in 30 ml acetic acid was added dropwise 7.5 g (46.7 mmol) bromine. The mixture was maintained at 70-80 C. overnight. The mixture was cooled and the acetic acid was removed under reduced pressure. Water (100 ml) was added and the product was filtered and washed with water (3*100 ml). The solid was dried in a vacuum oven at 65 C. for 48 hours to provide 6.1 g (78% yield) of the title compound. MS: m/z (APCI, AP+) 219.0 [M¡¤]+. CHN Analysis: Calcd: C, 33.06; H, 1.85; N, 6.42. Found: C, 32.91; H, 1.78; N, 6.23.

According to the analysis of related databases, 609-71-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Barvian, Nicole Chantel; Connor, David Thomas; O’Brien, Patrick Michael; Ortwine, Daniel Fred; Patt, William Chester; Shuler, Kevon Ray; Wilson, Michael William; US2002/161000; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, molecular weight is 139.1088, as common compound, the synthetic route is as follows.609-71-2

This compound was prepared according to the procedure of Y. S. Lo (Synthetic Communications, 1989, 553). Bromine (0.77 eq) was added dropwise at 0C to a stirred solution of 50% NAOH (2.4 eq) in water (1 M solution). After 5 min, 50% NAOH (3 eq) followed by solid 2- hydroxynicotinic acid (1 eq) was added to the mixture and the resulting solution was stirred at 50C. After 20 h, a solution prepared by adding bromine (0. 38 eq) to 50% NAOH (1. 2 eq) in water (1 M solution) was added to the reaction mixture and stirring continued for another 24 h at 50C. After that time the reaction mixture was cooled to 0C and acidified to pH 2 with concentrated hydrochloric acid to allow the formation of a solid which was isolated by filtration, washed with warm water/isopropanol (3: 1), then with diethyl ether and dried to afford 5-bromo-2- hydroxynicotinic acid (87%) as an off-white solid. OH (400 MHz; DMSO) 8.25 (1H, d, J 2.7), 8.33 (1H, d, J 2.7), 13.84 (2H, bs) ; BC (400 MHZ ; DMSO) 99.45, 117.97, 142.01, 147.42, 163.22, 163.88 ; M/Z (ES-) 218-216 (M-H)-.

Statistics shows that 609-71-2 is playing an increasingly important role. we look forward to future research findings about 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.

Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA; WO2004/110442; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem