Category: 612845-44-0

Panteleev, Jane published the artcileDomino Rhodium-Catalyzed Alkyne Arylation/Palladium-Catalyzed N Arylation: A Mechanistic Investigation, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Angewandte Chemie, International Edition (2011), 50(39), 9089-9092, S9089/1-S9089/32, database is CAplus and MEDLINE.

We report an example in which two different metals with two different phosphine ligands promote two out of three possible reactions and do so in a time-resolved way, thus leading to an efficient preparation of dihydroquinolines. Importantly, we show that one of the two phosphine ligands is selective in binding to only one of the metals, and the other ligand is nondiscriminating in its binding properties; yet one of the two metal-phosphine complexes is far more reactive and selectivity is observed This study raised the more general question of matching ligands and metals in order to efficiently promote only the desired reaction rather than competing processes. Thus, complex sequences of reactions that contain multiple catalytically active species can ultimately be created in a single reaction vessel.

Angewandte Chemie, International Edition published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Xiaofei published the artcileAlkylations of Arylboronic Acids including Difluoroethylation/Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Advanced Synthesis & Catalysis (2015), 357(12), 2721-2727, database is CAplus.

An efficient alkylation method of functionalized alkyl halides under mild nickel-catalyzed C(sp³) – C(sp²) Suzuki cross-coupling conditions was described. The features of this approach are excellent functional group compatibility, low cost nickel catalyst, and the use of a mild base. This is also the first successful example of the nickel-catalyzed direct 2,2-difluoroethylation or 2,2,2-trifluoroethylation of aryl-/heteroarylboronic acids.

Advanced Synthesis & Catalysis published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C19H17N2NaO4S, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Panteleev, Jane published the artcileDomino Rhodium-Catalyzed Alkyne Arylation/Palladium-Catalyzed N Arylation: A Mechanistic Investigation, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Angewandte Chemie, International Edition (2011), 50(39), 9089-9092, S9089/1-S9089/32, database is CAplus and MEDLINE.

We report an example in which two different metals with two different phosphine ligands promote two out of three possible reactions and do so in a time-resolved way, thus leading to an efficient preparation of dihydroquinolines. Importantly, we show that one of the two phosphine ligands is selective in binding to only one of the metals, and the other ligand is nondiscriminating in its binding properties; yet one of the two metal-phosphine complexes is far more reactive and selectivity is observed This study raised the more general question of matching ligands and metals in order to efficiently promote only the desired reaction rather than competing processes. Thus, complex sequences of reactions that contain multiple catalytically active species can ultimately be created in a single reaction vessel.

Angewandte Chemie, International Edition published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Xiaofei published the artcileAlkylations of Arylboronic Acids including Difluoroethylation/Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Advanced Synthesis & Catalysis (2015), 357(12), 2721-2727, database is CAplus.

An efficient alkylation method of functionalized alkyl halides under mild nickel-catalyzed C(sp³) – C(sp²) Suzuki cross-coupling conditions was described. The features of this approach are excellent functional group compatibility, low cost nickel catalyst, and the use of a mild base. This is also the first successful example of the nickel-catalyzed direct 2,2-difluoroethylation or 2,2,2-trifluoroethylation of aryl-/heteroarylboronic acids.

Advanced Synthesis & Catalysis published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C19H17N2NaO4S, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hynes, John Jr. published the artcileDiscovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(14), 3101-3106, database is CAplus and MEDLINE.

A series of potent dual JAK1/3 inhibitors have been developed from a moderately selective JAK3 inhibitor. Substitution at the C6 position of the pyrrolopyridazine core with aryl groups provided exceptional biochem. potency against JAK1 and JAK3 while maintaining good selectivity against JAK2 and Tyk2. Translation to in vivo efficacy was observed in a murine model of chronic inflammation. X-ray co-crystal structure determination confirmed the presumed inhibitor binding orientation in JAK3. Efforts to reduce hERG channel inhibition will be described.

Bioorganic & Medicinal Chemistry Letters published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xu, Chen published the artcileSynthesis and Structural Characterization of Palladacycles with Polydentate Ligands by a Stepwise Coupling Route – Palladacycles Containing Halides as Efficient Catalysts and Substrates, Related Products of pyridine-derivatives, the publication is European Journal of Inorganic Chemistry (2011), 2011(31), 4878-4888, database is CAplus.

A series of ferrocenyl palladacycles with polydentate ligands were conveniently prepared by the Suzuki coupling reactions of a halide-containing ferrocenyl palladacycle [PdCl({(η⁵-C₅H₅)}Fe{(η⁵-C₅H₃)N₂C₄H₂Cl})(PPh₃)] (1) and arylboronic acids without addnl. palladium catalysis. In the absence of addnl. base, amination also occurred in high yield. This new protocol was successfully applied to the Suzuki coupling reactions of the analogous halide-containing palladacycle [PdCl({(η⁵-C₅H₅)}Fe{(η⁵-C₅H₃)NC₅H₃Br})(PPh₃)] (15) and Buchwald-Hartwig amination of the analogous complex [PdCl({(η⁵-C₅H₅)}Fe{(η⁵-C₅H₃)NC₅H₃Br})(DCPAB)] (32), where DCPAB = 2-dicyclohexylphosphanyl-2′-(N,N-dimethylamino)biphenyl. The halide-containing palladacycles act as efficient catalysts and substrates in the coupling reactions. 37 New examples have been fully characterized by elemental anal., IR and ¹H NMR spectroscopy, and ESI-MS. Addnl., the mol. structures of eight compounds were determined by single-crystal x-ray diffraction, and many types of intermol. C-H···Cl (O, N, π) interactions and π-π interactions were found in the crystal structures of these palladacycles.

European Journal of Inorganic Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C20H19NO4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ban, Yan published the artcileThioamide directed iridium(I)-catalyzed C-H arylation of ferrocenes with aryl boronic acids, Computed Properties of 612845-44-0, the publication is Organic & Biomolecular Chemistry (2022), 20(29), 5759-5763, database is CAplus and MEDLINE.

The first Ir(I)-catalyzed thioamide-assisted C-H arylation of ferrocenes with aryl boronic acids under base-free mild reaction conditions in the presence of Ag₂CO₃ as an oxidant with eco-friendly 2-MeTHF as a solvent was developed. This reaction has a wide range of substrates (37 examples) and functional group tolerance (18-94% yields), and provides promising access to aryl thioamide-ferrocene compounds with good yields and regioselectivity.

Organic & Biomolecular Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Computed Properties of 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xia, Hongyu published the artcileVisible Light Induced Aerobic Coupling of Arylboronic Acids Promoted by Hydrazone, Category: pyridine-derivatives, the publication is Advanced Synthesis & Catalysis (2022), 364(5), 922-929, database is CAplus.

A visible-light-induced oxidative coupling of arylboronic acids was developed for the synthesis of biaryls Ar¹Ar² [Ar¹ = Ar² = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; Ar¹ = 4-BrC₆H₄, 4-MeC₆H₄, 4-FC₆H₄, etc.; Ar₂ = 4-H(O)CC₆H₄, 3-MeOC₆H₄, 4-AcC₆H₄, etc.]. The reaction that employed polydentate hydrazones as the bifunctional catalyst works smoothly under room temperature It was compatible with a wide range of functional group. The study of UV-Vis spectrum indicated that hydrazone and its complex with CuI show major absorptions upon visible-light, which secures the dual role of hydrazone as both ligand and photocatalyst in this reaction. Hence, the reaction was proposed to involve stepwise transmetallations, photo-induced oxidations, and reductive elimination.

Advanced Synthesis & Catalysis published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C9H9F5Si, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Elie, Jonathan published the artcileDesign of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [¹⁸F] PET tracer, Quality Control of 612845-44-0, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2019), 34(1), 1-7, database is CAplus and MEDLINE.

A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C-H activation were established in the indazole and azaindazole series resp. In vitro assays were conducted and structural modifications were carried out on these scaffolds to furnish compound which exhibited effective COX-2 inhibitory activity, with IC₅₀ values of 0.409 μM and an excellent selectivity vs. COX-1. Radiolabeling of this most potent derivative [¹⁸F] was achieved after boron ester release and the tracer was evaluated in vivo in a rat model of neuroinflammation. All chem., radiochem. and biol. exptl. data are discussed.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Quality Control of 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ishida, Akiharu published the artcileDiscovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly, COA of Formula: C7H10BNO3, the publication is ACS Chemical Neuroscience (2020), 11(10), 1482-1494, database is CAplus and MEDLINE.

Acromegaly is a disease caused by the oversecretion of growth hormone. It is currently treated by i.v. injection with cyclic peptide drugs that activate somatostatin receptor subtype 2 (SSTR2). Here, novel nonpeptidic, small-mol., and orally active SSTR2 agonists were identified from a hit compound (13). Pharmacophore studies enabled scaffold hopping to obtain a unique 3,4,5-trisubstituted pyridine motif. Further optimization conferred potent SSTR2 agonistic activity and metabolic stability. Several compounds were evaluated and these showed good oral pharmacokinetic profiles in rats, and one representative compound (25)(I) showed highly potent inhibition of growth hormone secretion induced by growth hormone-releasing hormone in rats. Based on these results, 25 was identified as a promising lead for further optimization. A structure-activity relationship (SAR) study and the metabolic stability data for this compound are also described.

ACS Chemical Neuroscience published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, COA of Formula: C7H10BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem