Category: 612845-44-0

Wang, Shengqiang published the artcileEfficient synthesis of 3-aryl-1H-indazol-5-amine by Pd-catalyzed Suzuki-Miyaura cross-coupling reaction under microwave-assisted conditions, COA of Formula: C7H10BNO3, the publication is Tetrahedron Letters (2015), 56(24), 3750-3753, database is CAplus.

Various 3-aryl-1H-indazol-5-amine derivatives were synthesized by Pd-catalyzed Suzuki-Miyaura cross-coupling reaction of (NH) free 3-bromo-indazol-5-amine with arylboronic acids under microwave-assisted conditions. The coupling reaction can be carried out under the conditions with dioxane/H₂O as solvent, Pd(OAc)₂ and RuPhos as catalyst system, and K₃PO₄ as a base in good to excellent yields.

Tetrahedron Letters published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C13H19N5OS, COA of Formula: C7H10BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nicolaus, Norman published the artcileModular Synthesis of Naphthothiophenes by Pd-Catalyzed Tandem Direct Arylation/Suzuki Coupling, Synthetic Route of 612845-44-0, the publication is Organic Letters (2011), 13(16), 4236-4239, database is CAplus and MEDLINE.

A short and highly modular three-step synthesis of a new class of substituted naphthothiophenes has been developed exploiting a Pd-catalyzed tandem direct arylation/Suzuki coupling transformation of 3-[2-(2,2-dibromovinyl)phenyl]thiophenes as the key step.

Organic Letters published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Synthetic Route of 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Al-Sanea, Mohammad M. published the artcileSynthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents, Application of (6-Ethoxypyridin-3-yl)boronic acid, the publication is Molecules (2015), 20(1), 1031-1045, 15 pp., database is CAplus and MEDLINE.

A series of phenyl(bipyridinyl)pyrazoles I (R = F, MeS, morpholin-4-yl, etc.) were synthesized and screened at 10 μM against over 60 tumor cell lines at the U.S. National Cancer Institute (NCI). Compounds I [R = pyrrolidin-1-yl, 4-benzylpiperazin-1-yl (II)] showed a broad spectrum of activity against NCI cell lines with mean growth of 53% and 58%, resp. Compound I [R = 4-methylpiperazin-1-yl (III)] behaved differently as it showed a high degree of selectivity and potency by inhibiting 96% of growth of leukemia SR cell line at 10 μM. Standard COMPARE anal. was performed at the GI₅₀ level and the results exhibited a high correlation in the form of pairwise correlation coefficient (PCC) of more than 0.6 between three of the current compounds and three standard known anticancer agents. Compound III demonstrated a high correlation level with merbarone (NSC S336628) with a PCC value of 0.631. Compound II showed a considerably high PCC value of 0.626 with dichloroallyl lawsone, while compound I (R = benzyloxy), showed PCC values of 0.601 and 0.604 with both dichloroallyl lawsone and N,N-dibenzyldaunomycin (NSC S268242), resp. These three standard agents have anticancer activity via two major mechanism of actions, inhibition of topoisomerase II and inhibition of biosynthesis of pyrimidine nucleotides, therefore, compounds I are promising therapeutic agents for targeting different human malignancies. Prediction of drug-likeness and toxicity of the synthesized derivatives I were also considered.

Molecules published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Application of (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Billingsley, Kelvin published the artcileHighly Efficient Monophosphine-Based Catalyst for the Palladium-Catalyzed Suzuki-Miyaura Reaction of Heteroaryl Halides and Heteroaryl Boronic Acids and Esters, Product Details of C7H10BNO3, the publication is Journal of the American Chemical Society (2007), 129(11), 3358-3366, database is CAplus and MEDLINE.

A highly active and efficient catalyst system derived from a palladium precatalyst and monophosphine ligands I or II for the Suzuki-Miyaura cross-coupling reaction of heteroaryl boronic acids and esters has been developed. This method allows for the preparation of a wide variety of heterobiaryls in good to excellent yields and displays a high level of activity for the coupling of heteroaryl chlorides as well as hindered aryl and heteroaryl halides. Specific factors that govern the efficacy of the transformation for certain heterocyclic motifs were also investigated.

Journal of the American Chemical Society published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Product Details of C7H10BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Parry, Paul R. published the artcileNew shelf-stable halo- and alkoxy-substituted pyridylboronic acids and their Suzuki cross-coupling reactions to yield heteroarylpyridines, Safety of (6-Ethoxypyridin-3-yl)boronic acid, the publication is Synthesis (2003), 1035-1038, database is CAplus.

New shelf-stable pyridylboronic acids have been synthesized: bromine-lithium exchange followed by reaction with triisopropylborate yielded 2-fluoro-5-pyridylboronic acid, 3-bromo-5-pyridylboronic acid and 2-ethoxy-5-pyridylboronic acid; directed lithiation followed by reaction with trimethylborate or triisopropylborate afforded 2-methoxy-3-pyridylboronic acid, 3-bromo-6-methoxy-4-pyridylboronic acid and 3-bromo-6-ethoxy-4-pyridylboronic acid. Cross-coupling of pyridylboronic acids with 3-bromoquinoline [Cs₂CO₃, Pd(PPh₃)₂Cl₂, 1,4-dioxane, 95 °C] gave pyridinylquinoline derivatives in 50-77% yields. Cross-coupling of (3-bromo-5-ethoxy-4-pyridinyl)boronic acid with 2-bromo-5-nitrothiophene gave 3-bromo-4-(5-nitro-2-thienyl)-6-ethoxypyridine (18).

Synthesis published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Safety of (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gentile, Gabriella published the artcileIdentification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors, HPLC of Formula: 612845-44-0, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(16), 4823-4827, database is CAplus and MEDLINE.

The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3β inhibitors is reported. X-ray crystallog. reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented.

Bioorganic & Medicinal Chemistry Letters published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, HPLC of Formula: 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Billingsley, Kelvin L. published the artcileA highly active catalyst for Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds, SDS of cas: 612845-44-0, the publication is Angewandte Chemie, International Edition (2006), 45(21), 3484-3488, database is CAplus and MEDLINE.

Catalysts derived from Pd and bulky dialkylphosphinobiaryl ligands are shown to be highly stable and active in Suzuki-Miyaura reactions of heteroaryl halides and heteroaryl boronic acids/esters (e.g., 3- or 4-pyridine, indole, and N-protected pyrrole derivatives). Furthermore, this catalyst system is not inhibited by the presence of highly basic aminopyridines or aminopyrimidines.

Angewandte Chemie, International Edition published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, SDS of cas: 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem