Category: 61338-13-4

Electric Literature of 61338-13-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 61338-13-4, name is 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Stirring blade,In a 1 L three-necked flask equipped with a thermometer, 60 g (201.8 mmol) of the pyridine carboxylic acid compound was suspended in 270 mL of tetrahydrofuran,It was cooled to 10 C.Under nitrogen flow70% sodium bis (2-methoxyethoxy) aluminum hydrideOf a toluene solution240 g (706.2 mmol) was added dropwise,The reaction was carried out at 40 C. for 5 hours.After completion of the reaction,The reaction solution was cooled to 10 C.,The reaction solution was added to 275 mL of a 35% by mass Rochelle salt aqueous solution cooled to 10 C. with stirring for 5 minutes.The temperature of the mixed solution at this time was 15 C.In addition, precipitation of aluminum hydroxide was not confirmed.Thereafter, the mixture was stirred for 10 minutes, and an organic layer and an aqueous layer were separated.The organic layer was concentrated under reduced pressure to obtain a pyridine methanol compound as a residue.240 mL of diethyl ether was added to the residue, and the mixture was stirred at room temperature for 30 minutes to obtain a crystallized pyridine methanol compound.After filtering the crystals,Dried under reduced pressure at 40 C. for 5 hours,Pyridine methanol compound (51 g).(Yield 89%, purity 99.3%, excess reductant amount 0.2%).

According to the analysis of related databases, 61338-13-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOKUYAMA CORPORATION; KASAI, SOKO; MIYAOKU, TAKAYUKI; (10 pag.)JP2017/154976; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 61338-13-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61338-13-4, name is 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid, molecular formula is C17H19N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 1000 ml three-necked flask, 600 ml of tetrahydrofuran, 2- (4-methyl-2-phenyl-1-piperazinyl)(134 g, 0.45 mol),Zinc chloride (306 g, 2.25 mol) was added sodium borohydride (85 g, 2.25 mol) in portions carefully. The temperature was raised to 60-85 C after addition and reflux with stirring for 16 hours, cooled to 0 C and carefully quenched with methanol The reaction mixture was removed under reduced pressure. 600 ml of 6N hydrochloric acid was added and the mixture was heated to 80 C with heating and stirred for 1 hour. The mixture was cooled to room temperature and extracted with methylene chloride (2 L × 3). The organic phase was dried over 1 kg of anhydrous sodium sulfate, A white solid was obtained. The white solid was further dried by blowing with air at 50 C to give 113 g of 1-(3-hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine as a white solid in 89% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 61338-13-4, 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid.

Reference:
Patent; Beijing Ha Sanlian Science And Technology Co., Ltd.; Harbin Sanlian Pharmaceutical Co., Ltd.; Liu Jinai; Li Yuanzhen; Ning Ruibo; Wang Mingxin; (8 pag.)CN105367571; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 61338-13-4, 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 61338-13-4, blongs to pyridine-derivatives compound. Safety of 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid

To a 1000 ml three-necked flask, 600 ml of tetrahydrofuran, 2- (4-methyl-2-phenyl-1-piperazinyl)(134 g, 0.45 mol),Zinc chloride (306 g, 2.25 mol) was added sodium borohydride (85 g, 2.25 mol) in portions carefully. The temperature was raised to 60-85 C after addition and reflux with stirring for 16 hours, cooled to 0 C and carefully quenched with methanol The reaction mixture was removed under reduced pressure. 600 ml of 6N hydrochloric acid was added and the mixture was heated to 80 C with heating and stirred for 1 hour. The mixture was cooled to room temperature and extracted with methylene chloride (2 L × 3). The organic phase was dried over 1 kg of anhydrous sodium sulfate, A white solid was obtained. The white solid was further dried by blowing with air at 50 C to give 113 g of 1-(3-hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine as a white solid in 89% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,61338-13-4, its application will become more common.

Reference:
Patent; Beijing Ha Sanlian Science And Technology Co., Ltd.; Harbin Sanlian Pharmaceutical Co., Ltd.; Liu Jinai; Li Yuanzhen; Ning Ruibo; Wang Mingxin; (8 pag.)CN105367571; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem