Category: 61889-48-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61889-48-3, name is 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride, the common compound, a new synthetic route is introduced below. Computed Properties of C7H7Cl2NO

Recombinant E. coli HB101 (pNTFPG) accession number FERM BP-7117 (April 11, 2000, International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken 305-8566 Japan) was inoculated in 50 ml of 2xYT medium, which was sterilized in a 500 ml Sakaguchi flask, and cultured by shaking at 37C for 18 hours. After 2 mg of NAD+ and 2.8 g of glucose were added to 40 ml of the obtained culture solution, 2 g of 3-(2-chloro-acetyl)pyridine hydrochloride was added over 5 hours while adjusting the pH to 6.5 at 30C and then agitation was conducted for 2 hours. After the reaction was finished, the reaction solution was extracted by ethyl acetate and concentrated under reduced pressure to obtain 1.6 g of yellow oily matter, which is the title compound. The chemical purity and optical purity were analyzed in the same manner as in Example 1. The chemical purity was 96.5 % and the optical purity was 99.0 %ee

The synthetic route of 61889-48-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KANEKA CORPORATION; EP1454899; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 61889-48-3, Adding some certain compound to certain chemical reactions, such as: 61889-48-3, name is 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride,molecular formula is C7H7Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61889-48-3.

Recombinant E. coli HB101 (pNTS1G) accession number FERM BP-5835 (February 24, 1997, International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken 305-8566 Japan) was inoculated in 50 ml of 2xYT medium (tryptone 16 g, yeast extract 10 g, sodium chloride 5 g, water 1 L, pH before sterilization 7.0), which was sterilized in a 500 ml Sakaguchi flask, and cultured ‘by shaking at 37C for 18 hours. After 40 mg of NADP+ and 56.1 g of glucose were added to 800 ml of the obtained culture solution, 40 g of 3-(2-chloro-acetyl)pyridine hydrochloride was added over 5 hours while adjusting the pH to 6.5 at 30C and then agitation was conducted for 2 hours. After the reaction was finished, the reaction solution was extracted by ethyl acetate and concentrated under reduced pressure, to obtain a 31.4 g of yellow oily matter, which is the title compound. The chemical purity and optical purity were analyzed in the same manner as in Example 1. The chemical purity was 97.8 % and the optical purity was 99.8 %ee.1H-NMR (D2O,400MHz/ppm); 3.62 (2H,bs), 4.66 (2H,s), 5.88 (1H,s)

According to the analysis of related databases, 61889-48-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KANEKA CORPORATION; EP1454899; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 61889-48-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61889-48-3, name is 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride. A new synthetic method of this compound is introduced below.

To a solution of (-)-B-chlorodiisopinocampheylborane [(-)-DIP-Cl] (25 g, 77.9 mmol) in tetrahydrofuran (90 ml) are added with stirring 3-(2-chloroacetyl)pyridine hydrochloride (Can. J. Chem., vol. 61, p. 334 (1983)) (3.0 g, 15.6 mmol) and triethylamine (2.39 ml, 17.2 mmol) at -25C, and the reaction mixture is stirred at -25C for 3 days. To this mixture is added water (300 ml), and the mixture is warmed to room temperature. To the mixture is added ethyl acetate, and the organic phase is separated. The aqueous phase is neutralized with a saturated aqueous sodium hydrogen carbonate solution, and extracted 6 times with ethyl acetate. The combined organic phase is dried over sodium sulfate, and concentrated under reduced pressure to give yellow oil, which is purified by silica gel column chromatography (methanol/chloroform = 1/20) to give the title compound (R)-2-chloro-1-pyridin-3-ylethanol (2.02 g, yield: 82 %) as pale yellow oil. 1H-NMR (CDCl3) delta: 2.75 (1H, d, J=3.4Hz), 3.67 (1H, dd, J=8.5, 11.3Hz), 3.78 (1H, dd, J=3.5, 11.3Hz),, 4.96-5.00 (1H,m), 7.33 (1H, dd, J=4.9, 7.9Hz), 7.75-7.78 (1H, m), 8.59 (1H, dd, J=1.6, 4.8Hz), 8.64 (1H, d, J=2.2Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,61889-48-3, its application will become more common.

Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1514869; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem