Category: 62150-46-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62150-46-3, name is 4-Bromopicolinamide, the common compound, a new synthetic route is introduced below. SDS of cas: 62150-46-3

The flask was charged with tris(dibenzylideneacetone)dipalladium (0) chloroform adduct (53.2 mg, 51.4 mumol), cesium carbonate (402 mg, 1.23 mmol), 4-bromo- picolinamide (103.4 mg, 0.514 mmol), 8-chloro-2-(2-chlorophenyl)quinoline-3- sulfonamide (200 mg, 0.566 mmol), tBuXPhos (37.0 mg, 77.2 mumol) and filled with N2. Thentoulene (15.0 ml ) was added and N2 was bubbled through the mixture for 10 minutes. The mixture was heated at 100C for 16 hours. The mixture was cooled to room temperature, evaporation of the solvent, diluted with CH2Cl2-MeOH (1:1, 25mL), filtered through a pad of Celite. The mixture was concentrated, and the residue was diluted with MeOH. The solution was purified by HPLC, 20%-70% of B in 35min. The collected fractions were concentrated and neutralized by adding aq. NaHCO3. Filtration and rinse with water gave 4-(8- chloro-2-(2-chlorophenyl)quinoline-3-sulfonamido)picolinamide, 1H-NMR (MeOD) delta 9.33 (s, 1 H), 8.21(d, J= 8.0 Hz, IH), 8.09 (d, J= 7.8 Hz, IH), 7.74 (t, J= 7.8 Hz, IH), 7.61 (s, 1 H), 7.36-7.50 (m, 6 H), 7.08 (d, J= 8.0 Hz, IH) . Mass Spectrum (ESI) m/e = 472.9 (M + 1).

The synthetic route of 62150-46-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; WO2008/118455; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62150-46-3, name is 4-Bromopicolinamide, the common compound, a new synthetic route is introduced below. SDS of cas: 62150-46-3

The flask was charged with tris(dibenzylideneacetone)dipalladium (0) chloroform adduct (53.2 mg, 51.4 mumol), cesium carbonate (402 mg, 1.23 mmol), 4-bromo- picolinamide (103.4 mg, 0.514 mmol), 8-chloro-2-(2-chlorophenyl)quinoline-3- sulfonamide (200 mg, 0.566 mmol), tBuXPhos (37.0 mg, 77.2 mumol) and filled with N2. Thentoulene (15.0 ml ) was added and N2 was bubbled through the mixture for 10 minutes. The mixture was heated at 100C for 16 hours. The mixture was cooled to room temperature, evaporation of the solvent, diluted with CH2Cl2-MeOH (1:1, 25mL), filtered through a pad of Celite. The mixture was concentrated, and the residue was diluted with MeOH. The solution was purified by HPLC, 20%-70% of B in 35min. The collected fractions were concentrated and neutralized by adding aq. NaHCO3. Filtration and rinse with water gave 4-(8- chloro-2-(2-chlorophenyl)quinoline-3-sulfonamido)picolinamide, 1H-NMR (MeOD) delta 9.33 (s, 1 H), 8.21(d, J= 8.0 Hz, IH), 8.09 (d, J= 7.8 Hz, IH), 7.74 (t, J= 7.8 Hz, IH), 7.61 (s, 1 H), 7.36-7.50 (m, 6 H), 7.08 (d, J= 8.0 Hz, IH) . Mass Spectrum (ESI) m/e = 472.9 (M + 1).

The synthetic route of 62150-46-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; WO2008/118455; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 62150-46-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62150-46-3, name is 4-Bromopicolinamide, molecular formula is C6H5BrN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of compound 53 (188 mg, 0.37 mmol), 4-bromopicolinamide (75 mg, 0.37 mmol) and 2 M aqueous Na2CO3 (0.6 mL, 1.20 mmol) in DME (3 mL) was degassed in vacuo for 15 min. To the mixture was added Pd(PPh3)4 (48 mg, 0.04 mmol) at room temperature. The mixture was stirred at 100 C under Ar for 8 h. The mixture was poured into water, and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (eluted with EtOAc in hexane), and crystallized from EtOAc/hexane to give the title compound (62 mg, 33%) as a white solid. mp: 220-222 C. 1H NMR (CDCl3) delta 1.14-1.29 (m, 2H), 1.59-1.76 (m, 2H), 2.20-2.30 (m, 4H), 2.94-3.05 (m, 1H), 3.61-3.75 (m, 1H), 4.60 (d, J = 7.2 Hz, 1H), 5.66 (br s, 1H), 6.34 (d, J = 8.7 Hz, 1H), 7.54 (dd, J = 8.7, 2.3 Hz, 1H), 7.65-7.75 (m, 1H), 7.86-7.94 (m, 3H), 7.99-8.06 (m, 2H), 8.29 (s, 1H), 8.48-8.50 (m, 1H), 8.71 (dd, J = 4.9, 0.8 Hz, 1H). LC/MS m/z 505.1 (M+H). Anal. Calcd for C24H23N4O3SF3: C, 57.13; H, 4.59; N, 11.10. Found: C, 57.04; H, 4.65; N, 10.92.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62150-46-3, 4-Bromopicolinamide.

Reference:
Article; Tawaraishi, Taisuke; Sakauchi, Nobuki; Hidaka, Kousuke; Yoshikawa, Kyoko; Okui, Toshitake; Kuno, Haruhiko; Chisaki, Ikumi; Aso, Kazuyoshi; Bioorganic and Medicinal Chemistry Letters; vol. 28; 18; (2018); p. 3067 – 3072;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 62150-46-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62150-46-3, name is 4-Bromopicolinamide, molecular formula is C6H5BrN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of compound 53 (188 mg, 0.37 mmol), 4-bromopicolinamide (75 mg, 0.37 mmol) and 2 M aqueous Na2CO3 (0.6 mL, 1.20 mmol) in DME (3 mL) was degassed in vacuo for 15 min. To the mixture was added Pd(PPh3)4 (48 mg, 0.04 mmol) at room temperature. The mixture was stirred at 100 C under Ar for 8 h. The mixture was poured into water, and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (eluted with EtOAc in hexane), and crystallized from EtOAc/hexane to give the title compound (62 mg, 33%) as a white solid. mp: 220-222 C. 1H NMR (CDCl3) delta 1.14-1.29 (m, 2H), 1.59-1.76 (m, 2H), 2.20-2.30 (m, 4H), 2.94-3.05 (m, 1H), 3.61-3.75 (m, 1H), 4.60 (d, J = 7.2 Hz, 1H), 5.66 (br s, 1H), 6.34 (d, J = 8.7 Hz, 1H), 7.54 (dd, J = 8.7, 2.3 Hz, 1H), 7.65-7.75 (m, 1H), 7.86-7.94 (m, 3H), 7.99-8.06 (m, 2H), 8.29 (s, 1H), 8.48-8.50 (m, 1H), 8.71 (dd, J = 4.9, 0.8 Hz, 1H). LC/MS m/z 505.1 (M+H). Anal. Calcd for C24H23N4O3SF3: C, 57.13; H, 4.59; N, 11.10. Found: C, 57.04; H, 4.65; N, 10.92.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62150-46-3, 4-Bromopicolinamide.

Reference:
Article; Tawaraishi, Taisuke; Sakauchi, Nobuki; Hidaka, Kousuke; Yoshikawa, Kyoko; Okui, Toshitake; Kuno, Haruhiko; Chisaki, Ikumi; Aso, Kazuyoshi; Bioorganic and Medicinal Chemistry Letters; vol. 28; 18; (2018); p. 3067 – 3072;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62150-46-3, name is 4-Bromopicolinamide, molecular formula is C6H5BrN2O, molecular weight is 201.0207, as common compound, the synthetic route is as follows.category: pyridine-derivatives

third step:Add water to the 50 liter reactor, sodium hydroxide, stir to reduce the temperature to 0 , add bromine, drop the temperature to minus 10 degrees.Add the amide in batches and stir for one hour.Then heat to 80 degrees for one hour.The TCL was detected until the end of the reaction, and the temperature was lowered to room temperature and centrifuged to obtain a crude product which was crystallized from toluene to give a pure product of 1.5 kg.The ratio of each raw material in the third step of Example 1 and the reaction conditions of the third step and the purity and yield of the obtained product are shown in Table 2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62150-46-3, 4-Bromopicolinamide, and friends who are interested can also refer to it.

Reference:
Patent; Chengdu Tong Chuangyuan Pharmaceutical Technology Co., Ltd.; Shou Yuehan; (12 pag.)CN105153023; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62150-46-3, name is 4-Bromopicolinamide, molecular formula is C6H5BrN2O, molecular weight is 201.0207, as common compound, the synthetic route is as follows.category: pyridine-derivatives

third step:Add water to the 50 liter reactor, sodium hydroxide, stir to reduce the temperature to 0 , add bromine, drop the temperature to minus 10 degrees.Add the amide in batches and stir for one hour.Then heat to 80 degrees for one hour.The TCL was detected until the end of the reaction, and the temperature was lowered to room temperature and centrifuged to obtain a crude product which was crystallized from toluene to give a pure product of 1.5 kg.The ratio of each raw material in the third step of Example 1 and the reaction conditions of the third step and the purity and yield of the obtained product are shown in Table 2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62150-46-3, 4-Bromopicolinamide, and friends who are interested can also refer to it.

Reference:
Patent; Chengdu Tong Chuangyuan Pharmaceutical Technology Co., Ltd.; Shou Yuehan; (12 pag.)CN105153023; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 62150-46-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62150-46-3, name is 4-Bromopicolinamide. This compound has unique chemical properties. The synthetic route is as follows.

The flask was charged with (2-(2-chlorophenyl)-8-methylquinolin-3-yl)methan- amine (100.0 mg, 0.354 mmol), obtained from A-1216 US PSP, procedure D, 4- bromopicolinamide (92 mg, 0.460 mmol), diisopropylethylamine (0.080 ml, 0.460 mmol) and 1-butanol (2.0 ml ) and sealed. The mixture was subjected to microwave at 180C for 4hrs. After cooled to room temperature, the mixture was concentrated, and the residue was diluted with MeOH. The solution was purified by HPLC, 25%-45% of B in 35min. The collected fractions were concentrated and dissolved in CH2Cl2, neutralized by washing with aq. NaHCO3. The CH2Cl2 layer was dried, concentrated and gave 4-((2-(2-chlorophenyl)-8-methylquinolin- 3-yl)methylamino)picolinamide, 1H-NMR (MeOD) delta 8.21 (s, 1 H), 8.01(d, J= 5.6 Hz, IH), 7.71 (d, J= 8.0 Hz, IH), 7.41-7.62 (m, 6 H), 7.20 (d, J= 2.4 Hz, IH), 6.50 (dd, J= 5.6,2.4 Hz, IH) 4.42 (d, J= 11.0 Hz, IH), 4.27 (d, J= 11.0 Hz, IH), 2.73 (s, 1 H). Mass Spectrum (ESI) m/e = 403.1 (M + 1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62150-46-3, 4-Bromopicolinamide.

Reference:
Patent; AMGEN INC.; WO2008/118455; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62150-46-3, name is 4-Bromopicolinamide, molecular formula is C6H5BrN2O, molecular weight is 201.0207, as common compound, the synthetic route is as follows.HPLC of Formula: C6H5BrN2O

EXAMPLE 64-((4-Oxo-3-o-tolyl-3,4-dihydropyrrolo[1 ,2-tf[1 ,2,4]triazin-2- yl)methylamino)picolinamideA mixture of 2-(aminomethyl)-3-o-tolylpyrrolo[1 ,2-7[1 .2,4]triazin-4(3H)-one (102 mg, 0.4 mmol), 4-bromopicolinamide (105 mg, 0.52 mmol) and DIEA (200 mu, 1 .13 mmol) in n- butanol (2.2 mL) was reacted under microwave irradiation at 190C during 22 h. After cooled to room temperature, the mixture was concentrated in vacuum and was purified by reverse phase chromatography (C-18 silica from Waters, water/1 :1 acetonitrile- methanol as eluents [0.1 % v/v formic acid buffered] 0% to 100%) to obtain 7 mg of the title compound (4,6%).LRMS (m/z): 375 (M+1 )+.1H NMR (400 MHz, DMSO) delta 8.38 (s, 2 H), 8.01 (d, J=5.86 Hz, 1 H), 7.90 (m, 1 H), 7.61 – 7.73 (m, 1 H), 7.48 – 7.58 (m, 1 H), 7.39 – 7.48 (m, 1 H), 7.23 – 7.40 (m, 2 H), 7.03 – 7.14 (m, 1 H), 6.93 – 7.04 (m, 1 H), 6.62 (dd, J=4.30, 2.74 Hz, 1 H), 6.38 – 6.53 (m, 1 H), 3.86 – 3.99 (m, 2 H), 2.08 (s, 3 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62150-46-3, 4-Bromopicolinamide, and friends who are interested can also refer to it.

Reference:
Patent; ALMIRALL, S.A.; BERNAL ANCHUELA, Francisco Javier; CARRASCAL RIERA, Marta; CATURLA JAVALOYES, Juan Francisco; GRACIA FERRER, Jordi; MATASSA, Victor Giulio; TERRICABRAS BELART, Emma; TALTAVULL MOLL, Joan; ERRA SOLA, Montserrat; WO2012/146666; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 62150-46-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62150-46-3, name is 4-Bromopicolinamide. This compound has unique chemical properties. The synthetic route is as follows.

The flask was charged with (2-(2-chlorophenyl)-8-methylquinolin-3-yl)methan- amine (100.0 mg, 0.354 mmol), obtained from A-1216 US PSP, procedure D, 4- bromopicolinamide (92 mg, 0.460 mmol), diisopropylethylamine (0.080 ml, 0.460 mmol) and 1-butanol (2.0 ml ) and sealed. The mixture was subjected to microwave at 180C for 4hrs. After cooled to room temperature, the mixture was concentrated, and the residue was diluted with MeOH. The solution was purified by HPLC, 25%-45% of B in 35min. The collected fractions were concentrated and dissolved in CH2Cl2, neutralized by washing with aq. NaHCO3. The CH2Cl2 layer was dried, concentrated and gave 4-((2-(2-chlorophenyl)-8-methylquinolin- 3-yl)methylamino)picolinamide, 1H-NMR (MeOD) delta 8.21 (s, 1 H), 8.01(d, J= 5.6 Hz, IH), 7.71 (d, J= 8.0 Hz, IH), 7.41-7.62 (m, 6 H), 7.20 (d, J= 2.4 Hz, IH), 6.50 (dd, J= 5.6,2.4 Hz, IH) 4.42 (d, J= 11.0 Hz, IH), 4.27 (d, J= 11.0 Hz, IH), 2.73 (s, 1 H). Mass Spectrum (ESI) m/e = 403.1 (M + 1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62150-46-3, 4-Bromopicolinamide.

Reference:
Patent; AMGEN INC.; WO2008/118455; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62150-46-3, name is 4-Bromopicolinamide, molecular formula is C6H5BrN2O, molecular weight is 201.0207, as common compound, the synthetic route is as follows.HPLC of Formula: C6H5BrN2O

EXAMPLE 64-((4-Oxo-3-o-tolyl-3,4-dihydropyrrolo[1 ,2-tf[1 ,2,4]triazin-2- yl)methylamino)picolinamideA mixture of 2-(aminomethyl)-3-o-tolylpyrrolo[1 ,2-7[1 .2,4]triazin-4(3H)-one (102 mg, 0.4 mmol), 4-bromopicolinamide (105 mg, 0.52 mmol) and DIEA (200 mu, 1 .13 mmol) in n- butanol (2.2 mL) was reacted under microwave irradiation at 190C during 22 h. After cooled to room temperature, the mixture was concentrated in vacuum and was purified by reverse phase chromatography (C-18 silica from Waters, water/1 :1 acetonitrile- methanol as eluents [0.1 % v/v formic acid buffered] 0% to 100%) to obtain 7 mg of the title compound (4,6%).LRMS (m/z): 375 (M+1 )+.1H NMR (400 MHz, DMSO) delta 8.38 (s, 2 H), 8.01 (d, J=5.86 Hz, 1 H), 7.90 (m, 1 H), 7.61 – 7.73 (m, 1 H), 7.48 – 7.58 (m, 1 H), 7.39 – 7.48 (m, 1 H), 7.23 – 7.40 (m, 2 H), 7.03 – 7.14 (m, 1 H), 6.93 – 7.04 (m, 1 H), 6.62 (dd, J=4.30, 2.74 Hz, 1 H), 6.38 – 6.53 (m, 1 H), 3.86 – 3.99 (m, 2 H), 2.08 (s, 3 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62150-46-3, 4-Bromopicolinamide, and friends who are interested can also refer to it.

Reference:
Patent; ALMIRALL, S.A.; BERNAL ANCHUELA, Francisco Javier; CARRASCAL RIERA, Marta; CATURLA JAVALOYES, Juan Francisco; GRACIA FERRER, Jordi; MATASSA, Victor Giulio; TERRICABRAS BELART, Emma; TALTAVULL MOLL, Joan; ERRA SOLA, Montserrat; WO2012/146666; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem