Category: 6221-01-8

Adding a certain compound to certain chemical reactions, such as: 6221-01-8, Pyridine-2,5-dicarbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H5NO2, blongs to pyridine-derivatives compound. Computed Properties of C7H5NO2

General procedure: To a solution of 2,5-dicarbaldehyde pyridine (50 mg), in 1,2-dichloroethane (3.6 mL), was added the aniline derivative (6 eq) and acetic acid (2 eq) were added. After stirring for 5 min at room temperature, the solution was treated with sodium triacetoxyborohydride (3 eq). It was then stirred at room temperature overnight and purified via preparative thin layer chromatography.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6221-01-8, Pyridine-2,5-dicarbaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Virani, Saniya; Liang, Zhongxing; Yoon, Younghyoun; Shim, Hyunsuk; Mooring, Suazette R.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 220 – 224;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6221-01-8, Pyridine-2,5-dicarbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Pyridine-2,5-dicarbaldehyde, blongs to pyridine-derivatives compound. Quality Control of Pyridine-2,5-dicarbaldehyde

General procedure: To a solution of 2,5-dicarbaldehyde pyridine (50 mg), in 1,2-dichloroethane (3.6 mL), was added the aniline derivative (6 eq) and acetic acid (2 eq) were added. After stirring for 5 min at room temperature, the solution was treated with sodium triacetoxyborohydride (3 eq). It was then stirred at room temperature overnight and purified via preparative thin layer chromatography.

The synthetic route of 6221-01-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Virani, Saniya; Liang, Zhongxing; Yoon, Younghyoun; Shim, Hyunsuk; Mooring, Suazette R.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 220 – 224;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6221-01-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6221-01-8, name is Pyridine-2,5-dicarbaldehyde. A new synthetic method of this compound is introduced below.

General procedure: To a stirred solution of 2,5-pyridinedicarboxaldehyde(0.37 mmol) in 5 mL EtOH was added the indole (1.85 mmol) andI2 (0.15 mmol). The resulting mixture was stirred at reflux for 6 hcooled and treated with aqueous Na2S2O3. The combined organiclayers obtained by extraction with EA (3 30 mL) were washedwith H2O (2 10 mL) and brine (2 10 mL), dried over MgSO4 and concentrated under reduced pressure to give a residue, which wassubjected to flash column chromatography, followed by normalphaseHPLC to afford the pure product. 4.3.2 3,3′,3″,3?-(Pyridine-2,5-diylbis(methanetriyl))tetrakis(1H-indole) (3a) Yield 50% (white powder), mp 164-165 C, 1H NMR (400 MHz, DMSO-d6): delta 10.85 (s, 2H, NH), 10.81 (s, 2H, NH), 8.51 (s, 1H, ArH), 7.59 (d, J = 8.4 Hz, 1H, ArH), 7.35-7.25 (m, 9H, ArH), 7.05-7.00 (m, 4H, ArH), 6.90 (s, 2H, ArH), 6.87-6.83 (m, 6H, ArH), 5.89 (s, 1H, CH), 5.86 (s, 1H, CH). 13C NMR (100 MHz, DMSO-d6): delta 162.48, 149.53, 138.42, 137.51, 137.36, 136.97, 127.65, 127.36, 124.49, 124.42, 122.88, 121.90, 121.74, 119.92, 119.20, 119.12, 118.32, 118.05, 112.45, 112.35, 43.21, 37.74. HRMS calcd for C39H30N5 (M + H)+, 568.2501; found, 568.2500.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6221-01-8, its application will become more common.

Reference:
Article; Fu, Chih-Wei; Hsieh, Yun-Jung; Chang, Tzu Ting; Chen, Chia-Ling; Yang, Cheng-Yu; Liao, Anne; Hsiao, Pei-Wen; Li, Wen-Shan; European Journal of Medicinal Chemistry; vol. 104; (2015); p. 165 – 176;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem