Category: 624-28-2

Reference of 624-28-2, Adding some certain compound to certain chemical reactions, such as: 624-28-2, name is 2,5-Dibromopyridine,molecular formula is C5H3Br2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-28-2.

SYNTHESIS OF INTERMEDIATE KETONE B2-(5-Bromopyridin-2-yl)- 1-(2,4-difluorophenyl)-2,2-difluoroethanone (B) To a suspension of copper powder (2.68 grams (g), 42.2 millimoles (mmol)) in dimethyl sulfoxide(DMSO; 35 milliliters (mL)) was added ethyl 2-bromo-2,2-difluoroacetate (2.70 mL, 21.10mmol), and the mixture was stirred for 1 hour (h) at room temperature (RT). 2,5-Dibromopyridine(2.50 g, 10.55 mmol) was then added, and stirring was continued for 15 h at RT. The reactionmixture was quenched with aqueous (aq) ammonium chloride (NH4C1) and extracted withdichloromethane (CH2C12 3 x 25 mL). The combined organic layers were washed with water (H20), washed with brine, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford the crude product mixture. Purification by column chromatography (eluting with ethyl acetate (EtOAc)/hexane) afforded the ethyl ester intermediate (2.40 g, 8.57mmol, 81%) as a pale yellow oil. ?H NMR (500 MHz, CDC13): oe 8.71 (s, 1H), 8.00 (d, J 9.0 Hz,1H), 7.64 (d, J= 9.0 Hz, 1H), 4.42-4.35 (m, 2H), 1.39-1.3 1 (m, 3H).

According to the analysis of related databases, 624-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DOW AGROSCIENCES LLC; GUSTAFSON, Gary, D.; HOEKSTRA, William, J.; LOSO, Michael, R.; YATES, Christopher, M.; WO2014/43376; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 624-28-2 ,Some common heterocyclic compound, 624-28-2, molecular formula is C5H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Procedure (take intermediate 3a as an example): 2,5-dibromopyridine (61.5 mmol), phenol (64.6 mmol), cuprous iodide (6.15 mmol), and Cs2CO3 (92 mmol) were placed in a 250 mL dried flask. Add 150 mL DMSO, then add TMEDA (6.15 mmol), heated to 110 degrees under Ar protection (Unless otherwise specified, the temperature in the present invention is in degrees Celsius C), react for about 20 hours, TLC conversion complete. After cooling to room temperature, a large amount of ethyl acetate was added, the mixture was washed 4 times with water and extracted twice with ethyl acetate. The combined EA (ethyl acetate) phase was washed with brine, and the organic layer was dried, filtered and evaporated to dryness to give the product as a brown oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624-28-2, 2,5-Dibromopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hangzhou He Zheng Pharmaceutical Co., Ltd.; Zhou Xinglu; Liu Xingguo; Luo Wenhua; Zhong Shichun; Huang Jinglai; Dong Xiaowu; Huang Wenhai; Hu Miao; (55 pag.)CN108069974; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 624-28-2, 2,5-Dibromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 624-28-2, blongs to pyridine-derivatives compound. Product Details of 624-28-2

3.1. 1,1-dimethylethyl 4-(5-bromo-2-pyridyl)-1-piperazinecarboxylate 29.2 g (157 mmol) of 1,1-dimethylethyl 1-piperazine-carboxylate, 37 g (157 mmol) of 2,5-dibromopyridine and 21.7 g (157 mmol) of potassium carbonate suspended in 27 ml of dimethyl sulfoxide (DMSO) are introduced into an autoclave. The mixture is then heated at 150 C. for 21 hours. The reaction mixture is allowed to cool to room temperature, it is taken up in ethyl acetate and water and the insoluble material is then separated out by filtration. The aqueous phase is separated out and extracted twice with ethyl acetate, the combined organic phases are washed with saturated aqueous sodium chloride solution and dried over sodium sulfate, and the filtrate is concentrated under reduced pressure. The residue obtained is purified by chromatography on silica gel, eluding with a 99/1 mixture of dichloromethane and methanol. 44 g of product are thus obtained in the form of a white solid. m.p. ( C.): 83-85 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,624-28-2, 2,5-Dibromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; SANOFI-AVENTIS; US2006/293310; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.624-28-2, name is 2,5-Dibromopyridine, molecular formula is C5H3Br2N, molecular weight is 236.892, as common compound, the synthetic route is as follows.Recommanded Product: 2,5-Dibromopyridine

The suspension of 11a (3.12g, 13.11mmol) in 15mL of morpholine was reacted under microwave condition for lOOmin at 12O0C. After the reaction was complete, 20OmL of ethyl acetate was added. The resulting solution was washed with 0.1N HCl (5OmL), water (10OmL), 0.1N NaOH (5OmL) and water (10OmL) subsequently. The resulting organic layer was dried over anhydrous Na2SCK and evaporated to provide lib (3.19g, 99.7%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,624-28-2, 2,5-Dibromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; XCOVERY, INC.; WO2008/88881; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 624-28-2, Adding some certain compound to certain chemical reactions, such as: 624-28-2, name is 2,5-Dibromopyridine,molecular formula is C5H3Br2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-28-2.

To a solution of phenol (1.97 g, 20.9 mmol) in N,N-dimethylformamide (100 mL) was added sodium hydride (1.00 g, 20.9 mmol) at 0 C., which was stirred for 5 minutes at 0 C. 2,5-Dibromopyridine (4.50 g, 19.0 mmol) was then added to this reaction solution at 0 C., and stirred for 40 minutes at room temperature. The reaction solution was then stirred for further 3 hours at 120 C. After allowing to room temperature, the reaction solution was partitioned into water and ethyl acetate. The organic layer was separated, washed with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=6:1) to obtain the title compound (3.85 g, 81%). 1H-NMR Spectrum (DMSO-d6) delta (ppm): 7.02 (1H, dd, J=0.55, 8.8 Hz), 7.11-7.14 (2H, m), 7.19-7.23 (1H, m), 7.38-7.43 (2H, m), 8.04 (1H, dd, J=2.6, 8.8 Hz), 8.25 (1H, dd, J=0.55, 2.6 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624-28-2, 2,5-Dibromopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/105904; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 624-28-2, Adding some certain compound to certain chemical reactions, such as: 624-28-2, name is 2,5-Dibromopyridine,molecular formula is C5H3Br2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-28-2.

(S)-l-(5-Bromo-pyridin-2-yl)-pyrrolidin-3-ol (Gl). A mixture of 2,5-dibromopyridine (12.2 g, 51.5 mmol) and (5)-hydroxypyrrolidine (2.80 g, 32.1 mmol) in toluene (50 mL) was heated to reflux overnight. The mixture was allowed to cool to rt, and the solvents were removed under reduced pressure. The residue was dissolved with EtOAc (150 mL), and the mixture was washed with aq. 10 % K2CO3. The org. layer was dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (heptane – > heptane/EtOAc 1 :2) yielded the title compound (3.62 g, 46%). LC-MS: tR = 0.48 min; ES+: 243.15.

According to the analysis of related databases, 624-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2007/88514; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 624-28-2, 2,5-Dibromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 624-28-2, blongs to pyridine-derivatives compound. Computed Properties of C5H3Br2N

To a stirred solution of 2,5-dibromopyridine (1.0 g, 4.2 mmol) in tert-butanol (5 ml) was added (S)-3-hydroxypyrrolidine (0.74 g, 8.44 mmol; Aldrich) and sodium carbonate (1.34 g, 12.70 mmol). The mixture was heated at 140 C. for 3 hours in a reacti-vial. After cooling to room temperature the mixture was diluted with water (20 ml) and extracted with ethyl acetate (20 ml). The aqueous component was separated and extracted with ethyl acetate (20 ml). The combined organic components were dried (Na2SO4), filtered and concentrated to give a brown oil. The crude product mixture was purified by column chromatography (eluding with 100% DCM?90:10:1 DCM:MeOH:NH3) to give the desired product as a white solid (1.0 g, 97%). 1H NMR (400 MHz, CDCl3) delta ppm 2.01-2.20 (m, 3H), 3.41-3.60 (m, 4H), 4.58-4.61 (m, 1H), 6.23 (d, 1H), 7.45 (dd, 1H), 8.11 (d, 1H). LRMS m/z (APCI) 377 [MH+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,624-28-2, its application will become more common.

Reference:
Patent; Pfizer Inc; US2008/85884; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 624-28-2 ,Some common heterocyclic compound, 624-28-2, molecular formula is C5H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under argon atmosphere,848 mL of a diethyl ether solution of 50.9 g of Compound 1 was cooled, and 131 mL of a 1.64 mol / L n-BuLi hexane solution was added dropwise at -62 C. or lower over 30 minutes.After stirring for 30 minutes at the same temperature,21.5 g of dehydrated N, N-dimethylacetamide was added dropwise over 10 minutes.Aqueous ammonium chloride solution was added and stirred at room temperature for 2 days. Extract with ethyl acetate,After drying the organic layer over anhydrous magnesium sulfate,Concentrated under reduced pressure. Without further purification,Compound 2 was used in the next reaction as it was.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624-28-2, 2,5-Dibromopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Chartwell Medical Instrument Co., Ltd.; Ji, Bin; Higuchi, Masato; Suhara, Tetsuya; Chen, Chun-jen; Fujimoto, Osuke; (15 pag.)JP2019/123675; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 624-28-2 as follows.

A 12L three-necked round-bottomed flask equipped with a mechanical stirrer and a condenser, connected on top with a nitrogen [BUBBLER] and a thermometer, was charged with 2,5-dibromopyridine (442 g, 1. [87MOLES),] hydrazine hydrate (55% wt., 1057 ml, [18.] 7 moles), poly (ethylene glycol) (average Mn about 300,1. 87 L), 2-butanol (373 [ML)] and water (1.87 L). The mixture was heated at reflux for 29 hours. The heating source was removed and the mixture was stirred for an additional 20 hours. To the resulting slurry, cold water [(2.] 2L) was added. The slurry was stirred for an additional [30] minutes and filtered. The cake was washed with cold water (3 x [200] [ML)] and dried in a vacuum-oven [(40C)] for 48 hours. The title compound was obtained as off-white flakes (305 g, yield 87%). GCMS (m/z): 187 (M+). [H’NMR] (400 MHz, [CDCI3)] : 8 8.14 (d, J=2.0 Hz, 1H), 7.55 (dd, J=8.7/2. 0 Hz, 1 H), 6.66 (d, J=8.7Hz, [1 H),] 5.89 (brs, 1 H), 3.65 (brs, 2H).

The chemical industry reduces the impact on the environment during synthesis 624-28-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/20438; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 624-28-2, name is 2,5-Dibromopyridine. This compound has unique chemical properties. The synthetic route is as follows.

Preparation 55 4-(5-Bromo-pvridin-2-vl)-morpholine; 2,5-Dibromopyridine (7.1 g, 30 mmol), morpholine (1.74 mL, 20 mmol), cesium carbonate (9.1 g, 28 mmol), tris (dibenzylideneacetone) dipalladium (0) (183 mg, 0.2 mmol), and racemic 2,2′-bis (diphenylphosphino)-1, 1′-binaphthyl (374 mg, 0.6 mmol) in toluene (20 mL) was heated at 120C for 24 hours. After cooling to room temperature, the mixture was filtered through CeliteT””and the Celte tu pad was washed with chloroform. The solution was concentrated in vacuo and was purified by silica gel chromatography (200: 1 chloroform- methanol) to give 2.9 g (60% yield) of the title compound. 13C NMR (100 MHz, CD03) d 158.3, 148. 7, 140.0, 108. 4, 66.8, 45.7 ; MS (AP/Cl) 243.0, 245.0 (M+H) +

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 624-28-2, 2,5-Dibromopyridine.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/90300; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem