Category: 625-82-1

Name: 2,4-Dimethyl-1H-pyrrole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about A nitroolefin based thiol fluorescent probe: synthesis and application in bioimaging. Author is Guo, Zhenbo; Zheng, Xueyang; Li, Xueyan; Jia, Qingfei; Zhang, Pingzhu; Wei, Chao; Li, Xiaoliu.

Intracellular small-mol. thiols, such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play pivotal roles in several physiol. and pathol. processes. A bodipy-nitroolefin-conjugated fluorescent probe based on photoinduced electron transfer (PET) mechanism was designed and successfully constructed. The probe selectively responds to biothiols by Michael addition reaction of the sulfhydryl group to the double bond activated by Nitroolefin moiety and gives an off-on fluorescent response. The fluorescence detection limit for GSH was calculated to be 11×10-9 mol/L. The results of fluorescence confocal imaging indicated that the probe has appreciable cell permeability and can serve as a fluorescent probe for detecting biothiols in living cells and zebrafish.

Different reactions of this compound(2,4-Dimethyl-1H-pyrrole)Name: 2,4-Dimethyl-1H-pyrrole require different conditions, so the reaction conditions are very important.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Oezcan, Emrah; Dedeoglu, Burcu; Chumakov, Yuri; Guerek, Ayse Guel; Zorlu, Yunus; Cosut, Buenyemin; Menaf Ayhan, Mehmet researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).COA of Formula: C6H9N.They published the article 《Halogen-Bonded BODIPY Frameworks with Tunable Optical Features**》 about this compound( cas:625-82-1 ) in Chemistry – A European Journal. Keywords: halogen bonded BODIPY preparation crystal structure fluorescence; optical band gap DFT halogen bonded BODIPY; BODIPY; fluorescence enhancement; halogen bonding; solid-state assemblies; tunable optical features. We’ll tell you more about this compound (cas:625-82-1).

The ability to tune the optical features of BODIPY materials in the solid state is essential for their photorelated application and requires efficient control of the crystal packing. Such control of BODIPY supramol. assemblies was achieved by deliberate design and synthesis of a BODIPY containing a strong halogen-bond (XB) acceptor (-NO2) and donor (I, Br) to mediate XB interactions. The di-halogenated structures formed isostructural monocoordinate motif B3, B4 (1D tubular structure) and sym. bifurcated motif B4-II (1D zigzag chains structure) through N-O···I, Br XB interactions. These XB interactions promote singlet-to-triplet intersystem crossing and triplet-to-singlet reverse intersystem crossing due to partial delocalization of oxygen electrons onto Br and I, which leads to unexpected fluorescence enhancement of B4-II. Finally, the indirect optical band gaps of B3, B4 and B4-II were amenable to tuning at 1.85-2.50 eV by XB-driven crystal packings.

《Halogen-Bonded BODIPY Frameworks with Tunable Optical Features**》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4-Dimethyl-1H-pyrrole)COA of Formula: C6H9N.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H9N. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas. Author is Subiros-Funosas, Ramon; Ho, Vivian Cheuk Lam; Barth, Nicole D.; Mendive-Tapia, Lorena; Pappalardo, Morena; Barril, Xavier; Ma, Ruoyu; Zhang, Cheng-Bin; Qian, Bin-Zhi; Sintes, Miquel; Ghashghaei, Ouldouz; Lavilla, Rodolfo; Vendrell, Marc.

Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophys. properties, and its application in a minimally-disruptive labeling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumor tissues.

The article 《Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas》 also mentions many details about this compound(625-82-1)Electric Literature of C6H9N, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Construction of an NIR and lysosome-targeted quinoline-BODIPY photosensitizer and its application in photodynamic therapy for human gastric carcinoma cells.Reference of 2,4-Dimethyl-1H-pyrrole.

In this work, a unique lysosome-targeted BODIPY photosensitizer named BOP-Lyso was designed for photodynamic therapy of cancer cells. The absorption wavelength of BOP-Lyso (10μM) was located at 650 nm and its molar absorption coefficient was 8.2 x 104 cm-1M-1. The emission wavelength of BOP-Lyso was at 709 nm. Photosensitizer BOP-Lyso showed excellent ability to produce singlet oxygen and the singlet oxygen yield of photosensitizer BOP-Lyso was calculated to be 43.1% using methylene blue as the reference with near-IR led light irradiation (660 nm). From MTT (a common method for determining cell survival rate, MTT: 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide) assay, BOP-Lyso had extremely low dark toxicity (cell viability > 85%) and high photo toxicity. And the IC50 value of BOP-Lyso was 0.24μM, which was much lower than the previously reported literature. Besides that, DCFH-DA (2′,7′-Dichlorodihydrofluorescein diacetate) was employed to capture the generation of reactive oxygen species (ROS) in PDT process. Lysosomal colocalization experiments demonstrated that photosensitizer BOP-Lyso had good co-localization capability and the colocalization coefficient was calculated to be 0.92. Furthermore, photosensitizer BOP-Lyso had also been successfully applied to AO/EB cell staining experiments and exhibited excellent results. Moreover, cancer cells (SGC-7901 cells, human gastric carcinoma cells) migration status could be effectively inhibited after NIR led light irradiation with BOP-Lyso. On the whole, taking the above series of data into account, photosensitizer BOP-Lyso would play an important role in actual PDT of cancer cells.

The article 《Construction of an NIR and lysosome-targeted quinoline-BODIPY photosensitizer and its application in photodynamic therapy for human gastric carcinoma cells》 also mentions many details about this compound(625-82-1)Reference of 2,4-Dimethyl-1H-pyrrole, you can pay attention to it, because details determine success or failure

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,4-Dimethyl-1H-pyrrole(SMILESS: CC1=CNC(C)=C1,cas:625-82-1) is researched.Name: 1H-Pyrazole-4-sulfonyl chloride. The article 《Reaction-based highly selective and sensitive monomer/polymer probes with Schiff base groups for the detection of Hg2+ and Fe3+ ions》 in relation to this compound, is published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. Let’s take a look at the latest research on this compound (cas:625-82-1).

It is urgent and important to detect heavy metals in environments. In this work, novel reaction-based fluorescent probes were obtained by Schiff base reaction. The probes with Schiff base moiety (-C=N-) undergo irreversible hydrolysis in the presence of Hg2+ and Fe3+. They exhibit perfect high selectivity and sensitivity to Hg2+and Fe3+ ions. Upon the addition of Hg2+and Fe3+, fluorescence intensity of the probes increased notably. And the color of the probe changes from brown to bright green under UV light, which can realize “”naked eye”” detection. In addition, Schiff base group was introduced into polyurethane chain through condensation polymerization reaction. As expected, the fluorescent polyurethane probe (P2) maintained the detection performance of its original small mols. (BSD). Even more P2 showed a more sensitive detection effect than BSD, and the detection limits of P2 for Hg2+ and Fe3+ reach 0.19 μM and 0.21 μM, resp. It indicates that Reaction-based probes could be a useful tool for the detection of Hg2+ and Fe3+.

After consulting a lot of data, we found that this compound(625-82-1)Safety of 2,4-Dimethyl-1H-pyrrole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 625-82-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Polyoxovanadate-iodobodipy supramolecular assemblies: new agents for high efficiency cancer photochemotherapy. Author is Gu, Yaqi; Li, Qi; Huang, Yichao; Zhu, Yingting; Wei, Yongge; Ruhlmann, Laurent.

Two novel polyoxovanadate-iodoBodipy supramol. assemblies, named as (2I-BDP-C6)2V6 and (2I-BDP-C6)3V10, were first synthesized by the self-assembly of anionic hexavanadate and decavanadate with cationic iodoBodipy for photochemotherapy, resp. The mechanisms for synergistic photochemotherapy of the anion-cation pairs were determined In particular, (2I-BDP-C6)3V10 can effectively kill liver cancer cells (HepG2) by synergetic chemotherapy as well as photodynamic therapy.

After consulting a lot of data, we found that this compound(625-82-1)Related Products of 625-82-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs.HPLC of Formula: 625-82-1.

A boron-dipyrromethene (BODIPY) -based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.

After consulting a lot of data, we found that this compound(625-82-1)HPLC of Formula: 625-82-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and photophysical properties of tumor-targeted water-soluble BODIPY photosensitizers for photodynamic therapy, published in 2020, which mentions a compound: 625-82-1, mainly applied to BODIPY photosensitizer photophys property photodynamic therapy antitumor; BODIPY; click reaction; lactose; photodynamic therapy; photosensitizer, Safety of 2,4-Dimethyl-1H-pyrrole.

The synthesis of three water-soluble lactose-modified 4,4-difluoro-4-bora-3a,4a-diaza-sindacene (BODIPY)-based photosensitizers with tumor-targeting capabilities is reported, including an investigation into their photodynamic therapeutic activity on three distinct cancer cell lines (human hepatoma Huh7, cervical cancer HeLa, and breast cancer MCF-7 cell lines). The halogenated BODIPY dyes exhibited a decreased fluorescence quantum yield compared to their non-halogenated counterpart, and facilitated the efficient generation of singlet oxygen species. The synthesized dyes exhibited low cytotoxicities in the dark and high photodynamic therapeutic capabilities against the treated cancer cell lines following irradiation at 530 nm. Moreover, the incorporation of lactose moieties led to an enhanced cellular uptake of the BODIPY dyes. Collectively, the results presented herein provide promising insights for the development of photodynamic therapeutic agents for cancer treatment.

Although many compounds look similar to this compound(625-82-1)Safety of 2,4-Dimethyl-1H-pyrrole, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Electron-Withdrawing Boron Dipyrromethene Dyes As Visible Light Absorber/Sensitizers on Semiconductor Oxide Surfaces, published in 2020-02-12, which mentions a compound: 625-82-1, Name is 2,4-Dimethyl-1H-pyrrole, Molecular C6H9N, Electric Literature of C6H9N.

The synthesis, characterization, and electrochem. and photophys. properties of the phosphonate-derivatized carbazole (CBZ) and boron dipyrromethene (BODIPY) chromophores in the dyes, BODIPY(CBZ)2PO3H2 (8) and BODIPY(Tol)2PO3H2 (7), are described. The oxide-bound dyes have been explored as light absorbers in dye-sensitized photoelectrosynthesis cell (DSPEC) applications. The BODIPY-CBZ phosphonate ester (6) features a broad, intense UV-visible absorption spectrum with absorptions at 297 and 650 nm that arise from mixed transitions at the CBZ and BODIPY units. Electrochem. measurements on BODIPY(CBZ)2Br (4) in 0.1 M [nBu4N][PF6] in dichloromethane, vs normal hydrogen electrode (NHE), reveal reversible oxidations at 1.19 and 1.41 V and a reversible reduction at -0.59 V. On indium tin oxide (ITO) and TiO2, a reversible one-electron oxidation appears for 7 at 0.86 and 0.90 V vs NHE in dichloromethane, resp., which demonstrates the redox stability on metal oxide surfaces. The results of nanosecond transient absorption measurements on SnO2/TiO2 electrodes provide direct evidence for excited-state electron injection into the conduction band of TiO2 following 590 nm excitation. A longer lifetime for 8+ compared to 7+ is consistent with extensive intramol. charge separation between the CBZ and BODIPY units on the surface. Photoelectrochem. studies on 8 on a SnO2/TiO2 photoanode resulted in sustained photocurrents with current maxima of ∼200 μA/cm2 with hydroquinone added as a reductant under 1 sun (AM1.5 100 mW·cm-2) illumination at pH 4.5 in 0.1 M acetate buffer and 0.4 M LiClO4. On mixed SnO2/TiO2 electrode surfaces, with the added catalyst [Ru(Mebimpy)((4,4′-(OH)2PO-CH2)2bpy)(OH2)]2+ and chromophores 7 and 8, addition of 0.1 M benzyl alc. resulted in sustained photocurrents of 12 and 35 μA/cm2, consistent with oxidation to benzaldehyde.

Although many compounds look similar to this compound(625-82-1)Electric Literature of C6H9N, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C6H9N. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Molecular Design of Highly Efficient Heavy-Atom-Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging. Author is Nguyen, Van-Nghia; Yim, Yubin; Kim, Sangin; Ryu, Bokyeong; Swamy, K. M. K.; Kim, Gyoungmi; Kwon, Nahyun; Kim, C-Yoon; Park, Sungnam; Yoon, Juyoung.

Novel BODIPY photosensitizers were developed for imaging-guided photodynamic therapy. The introduction of a strong electron donor to the BODIPY core through a Ph linker combined with the twisted arrangement between the donor and the BODIPY acceptor is essential for reducing the energy gap between the lowest singlet excited state and the lowest triplet state (ΔEST), leading to a significant enhancement in the intersystem crossing (ISC) of the BODIPYs. Remarkably, the BDP-5 with the smallest ΔEST (∼0.44 eV) exhibited excellent singlet oxygen generation capabilities in both organic and aqueous solutions BDP-5 also displayed bright emission in the far-red/near-IR region in the condensed states. More importantly, both in vitro and in vivo studies demonstrated that BDP-5 NPs displayed a high potential for photodynamic cancer therapy and bioimaging.

Although many compounds look similar to this compound(625-82-1)Formula: C6H9N, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem