Category: 625-82-1

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Yifeng; Ma, Chenggong; Zheng, Xuwei; Ju, Minzi; Fu, Yongqian; Zhang, Xing; Shen, Baoxing researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).Reference of 2,4-Dimethyl-1H-pyrrole.They published the article 《A red emission multiple detection site probe for detecting carboxylesterase 1 based on BODIPY fluorophore》 about this compound( cas:625-82-1 ) in Journal of Photochemistry and Photobiology, A: Chemistry. Keywords: BODIPY fluorophore carboxylesterase red emission multiple detection. We’ll tell you more about this compound (cas:625-82-1).

In this work, a BODIPY-based multi-site red emission fluorescent probe MRS-BOD for the detection of carboxylesterase 1 (CES1) was designed and synthesized. MRS-BOD showed good biocompatibility and could be used to monitor the activity of CES1 in living cells. MRS-BOD emission is located in the red emission region, which has the advantages of less background interference and less damage to biol. samples. MRS-BOD has multiple CES1 recognition sites, and the ultra-sensitive quantification of CES1 has been successfully achieved. The low detection limit of MRS-BOD was calculated as 2.5 ng/mL, and the fluorescence quantum yield was calculated as 0.49. This study can promote the development of CES1 fluorescent probes and help the identification of related diseases.

Although many compounds look similar to this compound(625-82-1)Reference of 2,4-Dimethyl-1H-pyrrole, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 625-82-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Author is Jin, Meng; Ji, Xiuna; Stoika, Rostyslav; Liu, Kechun; Wang, Lizhen; Song, Yang.

Berberine is a naturally occurred isoquinoline alkaloid that shows great potential for developing anticancer drugs. However, the problem stays of poor understanding of the mechanisms of anticancer action of berberine. It depends on evaluation of berberine’s pharmacokinetics, namely monitoring of its uptake and distribution in cells, tissues and organs. In order to address these problems, we have designed and synthesized a novel berberine derivative BBR-BODIPY bearing a fluorescent tag that allows screening its interaction with the targeted cells. It was shown that the synthesized fluorescent derivative could penetrate into human breast carcinoma MCF7 cells, and then induced apoptosis detected by the Western Blot anal. as changed expression of apoptosis-related proteins, including Bax, Bcl2, and Cyto C released from mitochondria, Cleaved Caspase 9, Cleaved PARP, Pro-Caspase 3, and Cleaved Caspase 3. The results of MitoTracker anal. followed by the confocal microscopy of sub-cellular localization of BBR-BODIPY in the MCF7 cells demonstrated excellent cell-penetrating ability of this compound even at low concentrations, and mitochondria was the main site of its accumulation. Together with the results of Western Blot anal., these data indicated that the mitochondria pathway might be involved in berberine-induced apoptosis.

Although many compounds look similar to this compound(625-82-1)HPLC of Formula: 625-82-1, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 625-82-1, is researched, Molecular C6H9N, about Heavy atom substituted near-infrared BODIPY nanoparticles for photodynamic therapy, the main research direction is heavy atom IR BODIPY nanoparticle photodynamic therapy.Synthetic Route of C6H9N.

Photodynamic therapy (PDT) is a promising alternative to cancer therapy for its non-invasive advantage. The rational design of ideal photosensitizers (PSs) is especially significant in PDT. Herein, we synthesized a diiodo-substituted BODIPY (SNBDP) with near-IR (NIR) region absorption and fluorescence emission by Knoevenagel condensation reaction. The SNBDP nanoparticles (NPs) were prepared by the nanopptn. method wrapped by poloxamer. As-prepared SNBDP NPs exhibited robust water stability and notable photostability. After cellular endocytosis, the NPs could elicit excellent cancer-killing effects with a low half maximal inhibitory concentration (10.55μM for HeLa and 13.46μM for A549 cells) due to good singlet oxygen quantum yield (ΦΔ = 40%) of PS derived from the heavy atom effect. Moreover, the favorable cancer cell inhibition efficacy could efficiently reduce the dark toxicity of drug. We believe this ingenious design could provide a reference value for the exploration of optimal PS for PDT.

Although many compounds look similar to this compound(625-82-1)Synthetic Route of C6H9N, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about A near-infrared and lysosomal targeting thiophene-BODIPY photosensitizer: Synthesis and its imaging guided photodynamic therapy of cancer cells, the main research direction is lysosome thiophene BODIPY photosensitizer preparation imaging cancer photodynamic therapy; Lysosomal targeting; NIR photosensitizer; Photodynamic therapy; Singlet oxygen; Thiophene-BODIPY.Recommanded Product: 2,4-Dimethyl-1H-pyrrole.

In this study, a novel NIR and lysosomal targeting thiophene-BODIPY photosensitizer SBOP-Lyso was synthesized to explore its potential applications in photodynamic therapy of A549 cells. In the strategy of designing SBOP-Lyso, S atom in thiophene as well as heavy atom I were introduced to promote ISC efficiency to ensure high singlet oxygen yield. A common lysosome targeted group (M1: 1-(2-morpholinoethyl)-1H-indole-3-carbaldehyde) was linked to SBOP to extend its wavelength to the NIR region. Its absorption peak was at 660 nm (εmax = 5.2 x 104 cm-1 M-1) and its corresponding emission peak was located at 705 nm. Singlet oxygen could be quickly generated by SBOP-Lyso in the presence of 660 nm LED irradiation and the singlet oxygen yield was up to 44.1%. In addition, it also had good biocompatibility and could enter cells or zebrafish in a short time. SBOP-Lyso had negligible dark cytotoxicity (cell survival rate > 80%) and excellent phototoxicity (IC50 = 0.2 μM). DCFH-DA (ROS indicator) proved that SBOP-Lyso could generate singlet oxygen with 660 nm LED irradiation Singlet oxygen produced by SBOP-Lyso could kill cancer cells in PDT process and it had the ability to effectively inhibit A549 cells migration. Besides that, lysosomal colocalization assay showed that it had good lysosomal localization ability (Pearson colocation coefficient, R = 0.93). Considering the above results, SBOP-Lyso as a unique lysosome-targeted photosensitizer with excellent properties would exhibit pos. results in PDT process of cancer cells.

Compounds in my other articles are similar to this one(2,4-Dimethyl-1H-pyrrole)Recommanded Product: 2,4-Dimethyl-1H-pyrrole, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 625-82-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Boron-dipyrromethene derivatives bearing N-alkyl phthalimide and amine substituents of potential application in the photoinactivation of bacteria. Author is Piskorz, Jaroslaw; Dlugaszewska, Jolanta; Porolnik, Weronika; Teubert, Anna; Mielcarek, Jadwiga.

Novel boron-dipyrromethene derivatives with N-alkyl phthalimide and amine substituents, including iodinated derivative, were synthesized and characterized using UV-Vis spectrophotometry, mass spectrometry (HRMS) and NMR spectroscopy. Non-iodinated analogs revealed high emission properties with fluorescence quantum yields (ΦF) between 0.48 and 0.58. But singlet oxygen generation quantum yields (ΦΔ) were low with values in the range of 0.01-0.06. Iodinated derivative revealed a strong heavy atom effect resulted in the red-shifted absorption and emission bands, fluorescence quenching with ΦF values of about 0.02, but increased singlet oxygen generation abilities with excellent ΦΔ values of 0.97 and 0.85 in methanol and ethanol, resp. In vitro photodynamic inactivation activity was evaluated on Gram-pos. cocci of Staphylococcus aureus and Gram-neg. rods of Escherichia coli. Novel BODIPY derivatives showed promising inactivation efficiency on S. aureus, with the highest activity for iodinated derivative, which reduced the number of bacteria by 3.6 logs10 at low 0.5 μM concentration However, none of the tested derivatives showed a satisfactory ability to eradicate E. coli. Only non-iodinated derivative with amine substituent, at high concentrations, showed some significant activity with log10 reduction values of 2.0 and 1.1 at 500 and 50 μM, resp. Nevertheless, the presented approach enabled to obtain novel BODIPY derivatives with promising photoinactivation activity and properties such as fluorescence and singlet oxygen generation efficacy, easy to modify by the heavy atom substitution. Also, peripheral phthalimide or amine groups can be used for further structural modifications.

Compounds in my other articles are similar to this one(2,4-Dimethyl-1H-pyrrole)Related Products of 625-82-1, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 625-82-1. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Cu-catalyzed click conjugation of cobalamin to a BODIPY-based fluorophore: A versatile tool to explore the cellular biology of vitamin B12. Author is Haghdoost, Mohammad Mehdi; Sauvageau, Etienne; Oguadinma, Paul; Tran, Hoang-Van; Lefrancois, Stephane; Castonguay, Annie.

The Cu-catalyzed click conjugation of an azide-functionalized vitamin B12 (cobalamin) and an alkyne-labeled 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) gave a highly stable fluorescent BODIPY-labeled vitamin B12 (λex/λem = 495/508 nm). The formation of what has been identified as an iodine adduct of the conjugate was also observed as a side-product during this reaction and could be removed using HPLC. BODIPY-labeled vitamin B12 was characterized by NMR and HR-ESI-MS. In vitro studies on wild-type human fibroblasts indicated that BODIPY-labeled vitamin B12 could internalize in a manner similar to that of untagged vitamin B12. ATP-binding cassette sub-family D member 4 (ABCD4) is a lysosomal localized transporter required to export vitamin B12 from the lysosomal lumen to the cytosol. Mutations in this transporter result in the accumulation of vitamin B12 in lysosomes. In human fibroblasts harbouring a mutation in ABCD4, BODIPY-labeled vitamin B12 accumulated in the lumen of lysosomes. The authors′ data suggests the potential use of BODIPY-labeled vitamin B12 to study the intracellular behavior of the vitamin in the context of disorders related to the abnormal cellular use of the vitamin. Moreover, results presented here demonstrate that click chem. could be exploited for the conjugation of vitamin B12 to various other fluorophores.

Compounds in my other articles are similar to this one(2,4-Dimethyl-1H-pyrrole)Recommanded Product: 625-82-1, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Fluorescence activation, patterning and enhancement with photogenerated radicals, a prefluorescent probe and silver nanostructures, the main research direction is fluorescent probe optical reflection silver nanoparticles.Application In Synthesis of 2,4-Dimethyl-1H-pyrrole.

We synthesized a dual fluorogenic system based on a boron-dipyrromethene (BODIPY) dye coupled with a paramagnetic 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) nitroxide. Electron exchange facilitates the non-radiative relaxation of the singlet state of the chromophore, partially quenching the fluorescence from the BODIPY moiety. Nonetheless, the system can be activated in solution or thin polymer films by UV (UVA) light in the presence of a free radical initiator. UVA illumination promotes the decomposition of the initiator, resulting in the release of a carbon-centered free radical. The dye-TEMPO probe can concomitantly trap the radical or undergo H-abstraction. Both processes consequently turn on the fluorescence and are reversible in nature. We used this protocol to optically imprint a fluorescent pattern on a surface. Moreover, we investigated metal-enhanced fluorescence (MEF) effects by silver nanostructures (AgNP) as a means to improve the performance of our mol. strategy for fluorescence activation. Overall, this work contributes toward the development of improved nanoparticle-dye systems for applications of light-activated fluorescence such as multicolor fluorescence patterning and microscopy, where shorter reaction times, milder conditions, reversibility and a more diverse selection of both excitation sources and emission wavelengths are beneficial.

Compounds in my other articles are similar to this one(2,4-Dimethyl-1H-pyrrole)Application In Synthesis of 2,4-Dimethyl-1H-pyrrole, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C6H9N. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Chitosan based macromolecular probes for the selective detection and removal of Fe3+ ion.

Chitosan has been widely used due to its biodegradable, cost-effective and environmentally friendly properties. Modification of chitosan attracts much attention as promising methods to detect and remove organic and inorganic pollutants. In this work, chitosan-based macromol. probes were designed and synthesized. The probes can detect Fe3+ in the presence of other metal ions. The detection mechanism is investigated as well. The prob′s fluorescence quenching upon the addition of Fe3+ ion could be ascribed to the complexation between the electron-deficient ion Fe3+ and ′C=N′ (electron-rich group) of fluorescent chitosan probes. What′s more, the obtained fluorescent macromol. probes can be used for the removal of Fe3+ in solution The probes could adsorb the Fe3+ in solution and the removal efficiency can reach as high as 62.0% while the removal efficiency of original chitosan is only 16.0%. μThe probes have good selective detection for Fe3+ and the detection limit reaches 1.2 M.

Compounds in my other articles are similar to this one(2,4-Dimethyl-1H-pyrrole)Computed Properties of C6H9N, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ou, Changjin; Zhang, Yewei; Ge, Wei; Zhong, Liping; Huang, Yong; Si, Weili; Wang, Wenjun; Zhao, Yongxiang; Dong, Xiaochen published the article 《A three-dimensional BODIPY-iron(III) compound with improved H2O2-response for NIR-II photoacoustic imaging guided chemodynamic/photothermal therapy》. Keywords: BODIPY iron compound preparation photoacoustic imaging photothermal chemotherapy cancer.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).Electric Literature of C6H9N. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.

3D boron dipyrromethene (BODIPY)-Fe(III) coordination polymer nanoparticles can extend absorption to 1300 nm for enhanced ligand-to-metal transfer. The nanoparticles show good cytotoxic hydroxyl radical ( ̇OH) generation ability, high photothermal conversion, and outstanding NIR-II photoacoustic imaging, displaying synergistic chemodynamic/photothermal therapy.

In some applications, this compound(625-82-1)Electric Literature of C6H9N is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 625-82-1, is researched, SMILESS is CC1=CNC(C)=C1, Molecular C6H9NJournal, Article, Research Support, Non-U.S. Gov’t, Organic & Biomolecular Chemistry called Red fluorescent pyrazoline-BODIPY nanoparticles for ultrafast and long-term bioimaging, Author is Zhang, Yuandong; Zheng, Xiaohua; Zhang, Liping; Yang, Zhiyu; Chen, Li; Wang, Lei; Liu, Shi; Xie, Zhigang, the main research direction is red fluorescent pyrazoline BODIPY nanoparticle bioimaging.Safety of 2,4-Dimethyl-1H-pyrrole.

Fluorescence bioimaging is very significant in studying biol. processes. Fluorescent nanoparticles (NPs) manufactured from aggregation-induced emission (AIE) materials, as promising candidates, have attracted more attention. However, it is still a challenge to explore suitable AIE NPs for bioimaging. Herein, the authors synthesized pyrazoline-BODIPY (PZL-BDP) with a donor and acceptor (D-A) structure by a condensation reaction, cultured its single crystal, and studied its twisted intramol. charge transfer (TICT) and AIE effects. PZL-BDP could self-assemble to form red fluorescent nanoparticles (PZL-BDP NPs) which showed a good fluorescence quantum yield of 15.8% in water. PZL-BDP NPs with excellent stability and biocompatibility exhibited a large Stokes shift (Δλ = 111 nm) which resulted in the reduction of external interference and enhancement of the fluorescence contrast. Furthermore, these nanoparticles could be readily internalized by HeLa cells and they stain the cells in just five seconds, indicating an ultrafast bioimaging protocol. Moreover, long-term tracking fluorescence signals in vivo for ∼12 days were obtained. The bright red fluorescence, ultrafast cell staining ability, and long-term in vivo tracking competence outline the great potential of rational design nanomaterials with AIE characteristics for monitoring biol. processes.

In some applications, this compound(625-82-1)Safety of 2,4-Dimethyl-1H-pyrrole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem