Category: 625-82-1

Wang, Lingfeng; Qian, Ying published the article 《Near-infrared quinoline-fluoroborodipyrrole dye: synthesis and lysosomal fluorescence imaging》. Keywords: near IR quinoline fluoroborodipyrrole dye lysosomal fluorescent imaging synthesis.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).SDS of cas: 625-82-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.

A near-IR region (NIR) fluoroborodipyrrole fluorescent dye (QBOP-lys) was synthesized through Knoevenagel condensation reaction. The D-A configuration of the QBOP-lys dyes was conjugated by two p-morpholine styrene with one 8-hydroxyquino BODIPY structure. This QBOP-lys dye has been characterized by NMR and high resolution mass spectrometry. In DMSO (DMSO) solution, the maximum absorption wavelength of QBOP-lys was at 698 nm and its molar extinction coefficient was 5.9×104 L·mol-1·cm-1, the maximum emission wavelength was at 770 nm and its stokes shift was 73 nm. Besides that, QBOP-lys has been prepared as water-soluble nano-silica fluorescent nanoparticles (QBOP-lys/SiO2). The maximum emission wavelength of QBOP-lys/SiO2 was 726 nm in pure aqueous solution and the fluorescence quantum of QBOP-lys/SiO2 was 0.33, which made QBOP-lys have good near-IR fluorescence emission characteristics in organic solvents or pure water. On the other hand, QBOP-lys was also used for lysosomal imaging in SGC-7901 cells, the colocalization coefficient of dye QBOP-lys with Lyso-Tracker Green, a com. lysosomal green dye, was up to 0.9. Besides that, after QBOP-lys incubate with cells SGC-7901 for 48 h, it could still maintain good fluorescence imaging performance which could be used for long-term tracking imaging. The spectroscopy experiments and cell experiments both proved that dye QBOP-lys was a very promising NIR dye in future application.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called BODIPY-based photoacid generators for light-induced cationic polymerization, published in 2020-02-07, which mentions a compound: 625-82-1, mainly applied to photoacid generator cationic photopolymerization bodipy ROMP, Recommanded Product: 2,4-Dimethyl-1H-pyrrole.

Photoacid generators (PAGs) are organic compounds that can generate protons (H+) upon irradiation with certain wavelengths of light. In this work, we designed and synthesized the first BODIPY-based PAGs with D-A and D-π-A conjugation structures and achieved green and red LED light-induced acid generation. By the use of red-light absorbance, red-LED-triggered cationic polymerization was demonstrated as a proof-of-concept application of these PAGs.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,4-Dimethyl-1H-pyrrole(SMILESS: CC1=CNC(C)=C1,cas:625-82-1) is researched.Formula: C6H6FNO. The article 《The best density functional theory functional for the prediction of 1H and 13C chemical shifts of protonated alkylpyrroles》 in relation to this compound, is published in Journal of Computational Chemistry. Let’s take a look at the latest research on this compound (cas:625-82-1).

The prediction of 13C chem. shifts can be challenging with d. functional theory (DFT). In this study 39 different functionals and three different basis sets were tested on three neutral alkylpyrroles and their corresponding protonated species. The calculated shielding constants were compared to exptl. data and results from previous calculations at the MP2. We find that the meta-hybrid functional TPSSh with either the Pople style basis set 6-311++G(2d,p) or the polarization consistent basis set pcSseg-1 gives the best results for the 13C chem. shifts, whereas for the 1H chem. shifts it is the TPSSh functional with either the 6-311++G(2d,p) or pcSseg-2 basis set. Including an explicit solvent mol. hydrogen bonded to NH in the alkylpyrroles improves the results slightly for the 13C chem. shifts. On the other hand, for 1H chem. shifts the opposite is true. Compared to calculations at the MP2 level none of the DFT functionals can compete with MP2 for the 13C chem. shifts but for the 1H chem. shifts the investigated DFT functionals are shown to give better agreement with experiment than MP2 calculations

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Pyridine – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,4-Dimethyl-1H-pyrrole(SMILESS: CC1=CNC(C)=C1,cas:625-82-1) is researched.Formula: C3H3ClN2O2S. The article 《8-[4-(2-Hydroxypropane-2-yl)phenyl]-1,3,4,4,5,7-hexamethyl-4-boron-3a,4a-diaza-S-indacene》 in relation to this compound, is published in Molbank. Let’s take a look at the latest research on this compound (cas:625-82-1).

During recent years, the BODIPY core became a popular scaffold for designing photoremovable protecting groups (PPG). In this paper, we report the synthesis of a new mol.-8-[4-(2-hydroxypropane-2-yl)phenyl]-1,3,4,4,5,7-hexamethyl-4-boron-3a,4a-diaza-S-indacene-by the treatment of meso-(4-CO2Me-phenyl)-BODIPY with excess of MeMgI. The product was characterized by 1H, 13C NMR and HRMS. The combination of BODIPY core with tertiary benzilyc alc. might be promising for utilizing this mol. as visible light removable PPG.

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Liu, Yingfan; Li, Xiaochuan; Sun, Saisai; Ji, Guangqian; Son, Young-A. published an article about the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1,SMILESS:CC1=CNC(C)=C1 ).Name: 2,4-Dimethyl-1H-pyrrole. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:625-82-1) through the article.

C14H15B2F4I2N4, triclinic, P1[n.772] (number 2), a = 7.5458(7) Å, b = 8.5659(6) Å, c = 8.6089(5) Å, α = 108.189(6)°, β = 110.492(7)°, γ = 98.678(7)°, V = 473.6 Å3, Z = 1, Rgt(F) = 0.0334, wRref(F2) = 0.0831, T = 296.5 K.CCDC number: 1831891. The title compound was synthesized from commerically available 2,4-dimethylpyrrole as the literature described, The key intermediate BOPHY (bis(difluoroboron) l,2-bis((lH- pyrrol-2-yl)methylene)hydrazine) was obtained by three steps including Vilsmeier-Haack formylation, amidation, and com- plexation. The title compound was synthesized according to the following procedure. In ethanol 50 mL, BOPHY 338 mg (1.0 mmol), iodine 635 mg (2.5 mmol), and hydroiodic acid 352 mg (2.0 mmol) were mixed. Then it was heated to be refluxed in the dark, resulting in a deep-red solution Once the BOPHY disappeared on the TLC plate, the reaction mixture was quenched by water 50 mL. After a succesive washing, extraction, concentration, and purification, a yellow powder was obtained (500 mg, 85%). Crystals were obtained by slow evaporation within 5 days.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2,4-Dimethyl-1H-pyrrole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about p-Pyridine BODIPY-based fluorescence probe for highly sensitive and selective detection of picric acid. Author is Li, Hongda; Jia, Rulin; Wang, Yan.

A novel fluorescence probe p-PBP (I) for PA was synthesized based on a basic N atom as the electronic donor. The probe could detect PA over TNT, CE, PETN, RDX, HMX, NB, NT, DNT, NP, DNP, and common inorganic explosive ions (K+, Ba2+, NH+4, NO-3, ClO-3, and ClO-4), and common ions (Na+, Ca2+, and Mg2+) with high selectivity. The fluorescence quenching was attributed to the photo-induced electron transfer (PET) processes from the excited state of p-PBP to the ground state PA. The detection limit of probe p-PBP for PA was as low as 13.06 nmol/L, which is far lower than the concentration stipulated by the Environmental quality standards for surface water. The response time was less than 30 s. Hence, the fluorescence probe p-PBP was successfully developed to detect the concentration level of PA in real samples, which would provide a novel quant. anal. method of PA in forensic science.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Chunqing; Sun, Qi; Zhao, Qiang; Cheng, Xinjian published an article about the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1,SMILESS:CC1=CNC(C)=C1 ).Formula: C6H9N. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:625-82-1) through the article.

It′s of vital importance to detect heavy metals in environment and living cells. In this work, four near-IR regions boron dipyrromethene (BODIPY) probes (QBPH, PBPH, QBP and PBP) are constructed based on two BODIPY precursors (QB, PB) for sensing of Fe3+. As expected, these four probes exhibit obvious colorimetric and ratiometric response to Fe3+. In addition, QBP and PBP display highly sensitive and selective performance for detection of Fe3+. More importantly, QBP and PBP are successfully applied to near IR imaging and detection of Fe3+ in living A549 cells; it indicates that these novel designed probes could be a useful tool for the studies of Fe3+ in living cells.

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Pyridine – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging, published in 2021-12-31, which mentions a compound: 625-82-1, mainly applied to meso paracyclophanyl BODIPY dye NIR imaging aggregation, Recommanded Product: 2,4-Dimethyl-1H-pyrrole.

J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-IR window. However, the design of the second near-IR fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-IR fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophys. properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clin. application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-IR imaging agents.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Materials Chemistry B: Materials for Biology and Medicine called The tumor phototherapeutic application of nanoparticles constructed by the relationship between PTT/PDT efficiency and 2,6- and 3,5-substituted BODIPY derivatives, Author is Yin, Juanjuan; Jiang, Xu; Sui, Guomin; Du, Yingying; Xing, Enyun; Shi, Ruijie; Gu, Chengzhi; Wen, Xiaona; Feng, Yaqing; Shan, Zhongqiang; Meng, Shuxian, which mentions a compound: 625-82-1, SMILESS is CC1=CNC(C)=C1, Molecular C6H9N, Safety of 2,4-Dimethyl-1H-pyrrole.

BODIPY dyes have recently been used for photothermal and photodynamic therapy of tumors. However, complex multi-material systems, multiple excitation wavelengths and the unclear relationship between BODIPY structures and their PTT/PDT efficiency are still major issues. In our study, nine novel BODIPY near-IR dyes were designed and successfully synthesized and then, the relationships between BODIPY structures and their PTT/PDT efficiency were investigated in detail. The results showed that modifications at position 3,5 of the BODIPY core with conjugated structures have better effects on photothermal and photodynamic efficiency than the modifications at position 2,6 with halogen atoms. D. functional theory (DFT) calculations showed that this is mainly due to the extension of the conjugated chain and the photoinduced electron transfer (PET) effect. By encapsulating BDPX-M with amphiphilic DSPE-PEG2000-RGD and lecithin, the obtained NPs not only show good water solubility and biol. stability, but also could act as superior agents for photothermal and photodynamic synergistic therapy of tumors. Finally, we obtained BODIPY NPs that exhibited excellent photothermal and photodynamic effects at the same time under single irradiation with an 808 nm laser (photothermal conversion efficiency: 42.76%, A/A0: ~0.05). In conclusion, this work provides a direction to design and construct phototherapeutic nanoparticles based on BODIPY dyes for tumor treatment.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jiao, Xinyue; Marin, Luminita; Cheng, Xinjian researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).Recommanded Product: 625-82-1.They published the article 《Fluorescent cellulose/testing paper for the sensitive and selective recognition of explosives 2,4,6-trinitrophenol and 2,4-dinitrophenylhydrazine》 about this compound( cas:625-82-1 ) in Journal of Photochemistry and Photobiology, A: Chemistry. Keywords: trinitrophenol dinitrophenylhydrazine cellulose sensor etherification. We’ll tell you more about this compound (cas:625-82-1).

2,4,6-trinitrophenol (TNP) and 2,4-dinitrophenylhydrazine (DNH) are harmful to the environment and human beings. Trace detection of TNP and DNH is worth of developing facile methods. In this work, cellulose powder and filter paper based fluorescence sensor are synthesized. Firstly, NH2CH2CH2- was introduced into cellulose through etherification reaction, and at the same time, a small mol. BODIPY with -CHO was synthesized. Then BODIPY was incorporated into cellulose by Schiff base reaction to obtain fluorescent macromol. probes. These fluorescent cellulose sensors can efficiently identify TNP and DNH, with the lowest detection limits of 2.8 x 10-7 M and 1.6 x 10-7 M, resp. Fluorescent filter paper is obtained via the same route. They also exhibit TNP and DNH identification ability. The method developed in filter paper not only expands the application range of cellulose, but also can efficiently identify the pollutants TNP and DNH, which is of great significance in theory and practical applications.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem