Category: 626-05-1

《Synthesis of Tridentate [1,2,4] Triazinyl-Pyridin-2-yl Indole Lewis Basic Complexants via Pd-Catalyzed Suzuki-Miyaura Cross-Couplingã€?was written by Gulledge, Zachary Z.; Tedder, Mariah L.; Lyons, Kyle R.; Carrick, Jesse D.. Synthetic Route of C5H3Br2NThis research focused ontriazinyl pyridinyl indole preparation; bromo triazinylpyridine indole boronicacid Suzuki Miyaura coupling palladium catalyst. The article conveys some information:

Full closure of the nuclear fuel cycle is predicated, in part, on defining efficient separations processes for the effective speciation of the neutron-absorbing lanthanides from the minor actinides post-PUREX. Pursuant to the aforementioned, a class of tridentate, Lewis basic procomplexants have been prepared leveraging a Pd-catalyzed Suzuki-Miyaura cross-coupling between 6-bromo-[1,2,4]-triazinylpyridine derivatives and various protected indole-boronic acids to afford functionalized 2-[6-(5,6-diphenyl-[1,2,4]triazin-3-yl)-pyridin-2-yl]-1H-indoles. A highly active catalyst/ligand system with low loadings was employed rapidly affording 26 examples in yields as high as 85%. Method optimization, substrate and indole scope, comparative anal. between coupling reagents, and a scale-up experiment are reported. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dibromopyridine(cas: 626-05-1Synthetic Route of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Synthetic Route of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ohnishi, Ryuhei; Ohta, Hidetoshi; Mori, Shigeki; Hayashi, Minoru published their research in Organometallics in 2021. The article was titled 《Cationic Dirhodium Complexes Bridged by 2-Phosphinopyridines Having an Exquisitely Positioned Axial Shielding Group: A Molecular Design for Enhancing the Catalytic Activity of the Dirhodium Core》.HPLC of Formula: 626-05-1 The article contains the following contents:

This report describes a strategy to create highly electrophilic dirhodium catalysts. The electrophilicity of lantern-type dirhodium complexes is generally decreased by the coordination of a ligand to the axial site, which often causes a reduction in the catalytic activity. The authors designed and synthesized cationic dirhodium complexes bridged by 2-diarylphosphinopyridines having a bulky 2,4,6-triisopropylphenyl (Tip) group that can prevent the attack of external mols. to the closest axial site. Theor. calculations indicated that the Tip group weakly interacts with the axial site but hardly reduces the electrophilicity of the dirhodium core. The complexes served as excellent catalyst precursors for the dehydrogenative silylation of alcs. using hydrosilanes under mild conditions and a low metal loading, producing the silyl ethers in higher yields in comparison to conventional dirhodium complexes. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C5H3Br2NIn 2021 ,《Reductive Dimerization of Macrocycles Activated by BBr3》 appeared in Organic Letters. The author of the article were Kijewska, Monika; Siczek, Milosz; Pawlicki, Milosz. The article conveys some information:

Dimeric dipyridyl-carbazolyl boron dicationic complex I was prepared by BBr3-promoted dimerization of dipyridyl carbazole carbonyl-bridged macrocycle. A macrocyclic motif composed of carbazole and pyridine subunits linked by a carbonyl bridge (C:O) forms a skeleton with a peripheral reactivity that leads to a pinacol-like coupling activated by BBr3, eventually entrapping a substantially elongated C-C bond. Slightly modified conditions lead to the efficient transformation of the C=O unit to a CH2 linker that, after exposure to air, gives a dimeric mol. with multiple bonds between two macrocyclic units, as documented in spectroscopy and x-ray anal. The experimental process involved the reaction of 2,6-Dibromopyridine(cas: 626-05-1Computed Properties of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Enantiopure substituted pyridines as promising antimalarial drug candidates》 was published in Tetrahedron in 2020. These research results belong to Bentzinger, Guillaume; Pair, Etienne; Guillon, Jean; Marchivie, Mathieu; Mullie, Catherine; Agnamey, Patrice; Dassonville-Klimpt, Alexandra; Sonnet, Pascal. Formula: C5H3Br2N The article mentions the following:

The enantioselective synthesis and biol. evaluation of 4-(2-amino-1-hydroxyethyl)pyridines I [R1 = n-Bu, n-pentyl, n-hexyl, n-heptyl] as new antimalarial drug candidates was described. In particular, two routes to obtain the key-intermediate 4-vinyl-pyridine were studied. These routes were based on a Krohnke-type cyclization or on metal-catalyzed reactions. The Krohnke-type cyclization route was faster but only efficient at low scale since this pathway involved a Wittig reaction that requires severe temperature-control. Consequently, we designed a second route based on metal-catalyzed reactions. This way was longer but the 4-vinyl-pyridine could be obtained on a 5 g scale at least. Finally, a regioselective SN2 ring-opening of enantiopure epoxides by alkyl primary amines allowed the synthesis of eight I with global yields up to 41%. These compounds showed strong in vitro antimalarial activity against P. falciparum strains and were more active that chloroquine and mefloquine. These results demonstrated that I were promising antimalarial drug candidates. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2,6-DibromopyridineIn 2020 ,《Synthesis of Pyridylsulfonium Salts and Their Application in the Formation of Functionalized Bipyridines》 appeared in Organic Letters. The author of the article were Duong, Vincent K.; Horan, Alexandra M.; McGarrigle, Eoghan M.. The article conveys some information:

An S-selective arylation of pyridylsulfides with good functional group tolerance was developed. To demonstrate synthetic utility, the resulting pyridylsulfonium salts were used in a scalable transition-metal-free coupling protocol, yielding functionalized bipyridines with extensive functional group tolerance. This modular methodol. permits selective introduction of functional groups from com. available pyridyl halides, furnishing sym. and unsym. 2,2′- and 2,3′-bipyridines. Iterative application of the methodol. enabled the synthesis of a functionalized terpyridine with three different pyridine components. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2,6-DibromopyridineIn 2020 ,《Tuning Second Coordination Sphere Interactions in Polypyridyl-Iron Complexes to Achieve Selective Electrocatalytic Reduction of Carbon Dioxide to Carbon Monoxide》 was published in Inorganic Chemistry. The article was written by Zee, David Z.; Nippe, Michael; King, Amanda E.; Chang, Christopher J.; Long, Jeffrey R.. The article contains the following contents:

The development of noble-metal-free catalysts capable of electrochem. converting CO2 (CO2) selectively into value-added compounds remains one of the central challenges in catalysis research. Here, the authors present a systematic study of Fe(II) complexes of the functionalized ligands bpyRPY2Me (bpyPY2Me = 6-(1,1-bis(pyridin-2-yl)ethyl)-2,2′-bipyridine) in the pursuit of H2O-stable mol. Fe complexes that are selective for the catalytic formation of CO from CO2. Taking advantage of the inherently high degree of tunability of this ligand manifold, the authors followed a bioinspired approach by installing protic functional groups of varying acidities (-H, -OH, -OMe, -NHEt, and -NEt2) into the ligand framework to systematically modify the 2nd coordination sphere of the Fe center. This family of [(bpyRPY2Me)FeII] complexes was characterized using single-crystal x-ray anal., 1H NMR spectroscopy, and mass spectrometry. Comparative catalytic evaluation of this set of compounds via voltammetry and electrolysis experiments identified [(bpyNHEtPY2Me)Fe]2+ in particular as an efficient, Fe-based, nonheme CO2 electroreduction catalyst that displays significant selectivity for the conversion of CO2 to CO in MeCN solution with 11 M H2O. Probably the NH group acts as a local proton source for cleaving the C-O bond in CO2 to form CO. The complex with the most acidic functional group in the 2nd coordination sphere, [(bpyOHPY2Me)Fe]2+, favors formation of H2 over CO. The authors’ results correlate the selectivity of H2O vs. CO2 reduction to the acidity of the 2nd coordination sphere functional group and emphasize the continued untapped potential that synthetic mol. chem. offers in the pursuit of next-generation CO2 reduction electrocatalysts. The 2nd coordination sphere is systematically altered in polypyridyl-Fe(II) complexes, [(bpyRPY2Me)FeII]2+, with protic functional groups of varying acidities (R = -H, -OH, -OMe, -NHEt, -NEt2). [(BpyNHEtPY2Me)Fe]2+ is an efficient CO2 electroreduction catalyst that is selective for the conversion of CO2 to CO in MeCN solution with 11 M H2O. The complex with the most acidic functional group in the 2nd coordination sphere, [(bpyOHPY2Me)Fe]2+, favors formation of H2 over CO. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Reference of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Revealing the role of 1,2,4-triazolate fragment of blue-emitting bis-tridentate Ir(III) phosphors: photophysical properties, photo-stabilities, and applications》 was written by Zhu, Z.-L.; Hsu, L.-Y.; Tai, W.-S.; Ni, S.-F.; Lee, C.-S.; Chi, Y.. HPLC of Formula: 626-05-1This research focused ontriazolate bistridentate iridium phosphor photophys property photostability application OLED. The article conveys some information:

Novel bis-tridentate Ir(III) complexes are of great interest in the development of blue-emitting organic light-emitting diodes (OLEDs) due to their rigid and robust mol. architecture. In this work, both the functional 6-pyrazolyl-2-phenoxypyridine (pzyPx) and 6-(1,2,4-triazolyl)-2-phenoxypyridine (tazPx) were used as chromophoric chelates in the construction of the blue-emitting Ir(III) phosphors. Accordingly, the substitution of pzyPx with tazPx chelates retains the desired characteristics, i.e. both high quantum yields (>92%) in solution and shortened radiative lifetime (τrad) (from 19.8 to 2.5 μs), resp. The theor. calculation reveals that the triazolate moiety contributes considerably to the radiative transition, to which the greater iridium involvement in T1 → S0 transition of tazPx-based complex is responsible for the shortened τrad. Consequently, enhanced photostabilities in degassed toluene and competitive performances with maximum EQE of 19.2% with CIE coordinates of (0.17, 0.22) were observed from the tazPx-based complex Px-33. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Becker, Mariia; Wyss, Vanessa; Housecroft, Catherine E.; Constable, Edwin C. published an article in 2021. The article was titled 《The influence of alkyl chains on the performance of DSCs employing iron(II) N-heterocyclic carbene sensitizers》, and you may find the article in Dalton Transactions.Related Products of 626-05-1 The information in the text is summarized as follows:

The photovoltaic performances of DSCs employing two new iron(II) N-heterocyclic carbene (NHC) sensitizers are presented. The presence of Bu side chains had a significant impact on DSC performace. The improvement in DSC performance up to 0.93-0.95% was observed for a new heteroleptic sensitizer bearing one carboxylic acid anchoring group. The photovoltaic performance was remarkably affected by sensitization time and by a presence/absence of coadsorbent on the semiconductor surface. The highest photoconversion efficiencies (PCE) were achieved for DSCs sensitized over 17.5 h without addition of coadsorbents. However, for a shorter dipping time of 4 h, the presence of chenodeoxycholic acid improved the PCE from 0.46% (no coadsorbents) to 0.74%, resp. The performance of DSCs based on a new homoleptic complex bearing two Bu side chains and a carboxylic acid anchor on each NHC-ligand was improved from 0.05 to 0.29% via changes in dye-bath concentration and sensitization time. The changes in the dye load on the semiconductor surface depending on the sensitization conditions were confirmed using solid-state UV-Vis spectroscopy and thermogravimetric anal. Electrochem. impedance spectroscopy was used to gain information about the processes occurring at the different interfaces in the DSCs. The impedance response was strongly affected by the immersion time of the photoanodes in the dye-bath solutions In the case of the homoleptic iron(II) complex, a Gerischer impedance was observed after 17.5 h immersion. Shorter dipping times resulted in a decrease in the resistance in the system. For the heteroleptic complex, values of the chem. capacitance and electron lifetime were affected by the immersion time. However, the diffusion length was independent of sensitization conditions. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Related Products of 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Related Products of 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,6-DibromopyridineIn 2020 ,《Synthesis of polystyrene-supported Pd(II)-containing macrocyclic complex as a reusable catalyst for chemoselective Suzuki-Miyaura coupling reaction》 appeared in Tetrahedron Letters. The author of the article were Yamamoto, Koji; Nameki, Riku; Sogawa, Hiromitsu; Takata, Toshikazu. The article conveys some information:

A polystyrene-supported Pd complex bearing a cyclic pyridine-2,6-bisiamide ligand was synthesized and its catalytic activity in the Suzuki-Miyaura coupling reaction of 2,6-bromopyridine with 4-methoxyphenylboronic acid in aqueous media was investigated. The solid-supported catalyst exhibited catalytic activity and chemoselectivity that were comparable to those of homogeneous catalyst. The reusability of the solid-supported catalyst was also examined The experimental process involved the reaction of 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A nitrogen-doped nanotube molecule with atom vacancy defects》 was written by Ikemoto, Koki; Yang, Seungmin; Naito, Hisashi; Kotani, Motoko; Sato, Sota; Isobe, Hiroyuki. Recommanded Product: 2,6-Dibromopyridine And the article was included in Nature Communications in 2020. The article conveys some information:

Nitrogen-doped carbon nanotubes have attracted attention in various fields, but lack of congeners with discrete mol. structures has hampered developments based on in-depth, chem. understandings. In this study, a nanotube mol. doped periodically with multiple nitrogen atoms has been synthesized by combining eight 2,4,6-trisubstituted pyridine units with thirty-two 1,3,5-trisubstituted benzene units. A synthetic strategy involving geodesic phenine frameworks is sufficiently versatile to tolerate pyridine units without requiring synthetic detours. Crystallog. analyses adopting aspherical multipole atom models reveal the presence of axially rotated structures as a minor disordered structure, which also provides detailed mol. and electronic structures. The nitrogen atoms on the nanotube serve as chem. distinct sites covered with neg. charged surfaces, and they increase the chance of electron injections by lowering the energy levels of the unoccupied orbitals that should serve as electron acceptors. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem