Category: 626-05-1

Formula: C5H3Br2NIn 2019 ,《Pyrenylpyridines: Sky-Blue Emitters for Organic Light-Emitting Diodes》 appeared in ACS Omega. The author of the article were Deepthika De Silva, Thenahandi Prasanthi; Youm, Sang Gil; Tamas, George G.; Yang, Boqian; Wang, Chun-Han; Fronczek, Frank R.; Sahasrabudhe, Girija; Sterling, Sierra; Quarels, Rashanique D.; Chhotaray, Pratap K.; Nesterov, Evgueni E.; Warner, Isiah M.. The article conveys some information:

A novel sky-blue-emitting tripyrenylpyridine derivative, 2,4,6-tri(1-pyrenyl)pyridine (2,4,6-TPP), has been synthesized using a Suzuki coupling reaction and compared with three previously reported isomeric dipyrenylpyridine (DPP) analogs (2,4-di(1-pyrenyl)pyridine (2,4-DPP), 2,6-di(1-pyrenyl)pyridine (2,6-DPP), and 3,5-di(1-pyrenyl)pyridine (3,5-DPP)). As revealed by single-crystal X-ray anal. and computational simulations, all compounds possess highly twisted conformations in the solid state with interpyrene torsional angles of 42.3°-57.2°. These solid-state conformations and packing variations of pyrenylpyridines could be correlated to observed variations in phys. characteristics such as photo/thermal stability and spectral properties, but showed only marginal influence on electrochem. properties. The novel derivative, 2,4,6-TPP, exhibited the lowest degree of crystallinity as revealed by powder X-ray diffraction anal. and formed amorphous thin films as verified using grazing-incidence wide-angle X-ray scattering. This compound also showed high thermal/photo stability relative to its disubstituted analogs (DPPs). Thus, a nondoped organic light-emitting diode (OLED) prototype was fabricated using 2,4,6-TPP as the emissive layer, which displayed a sky-blue electroluminescence with Commission Internationale de L’Eclairage (CIE) coordinates of (0.18, 0.34). This OLED prototype achieved a maximum external quantum efficiency of 6.0 ± 1.2% at 5 V. The relatively high efficiency for this simple-architecture device reflects a good balance of electron and hole transporting ability of 2,4,6-TPP along with efficient exciton formation in this material and indicates its promise as an emitting material for design of blue OLED devices. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dibromopyridine(cas: 626-05-1Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Excimer Disaggregation Enhanced Emission: A Fluorescence “”Turn-On”” Approach to Oxoanion Recognition》 were Yang, Jian; Dong, Chao-Chen; Chen, Xu-Lang; Sun, Xin; Wei, Jin-Yan; Xiang, Jun-Feng; Sessler, Jonathan L.; Gong, Han-Yuan. And the article was published in Journal of the American Chemical Society in 2019. Safety of 2,6-Dibromopyridine The author mentioned the following in the article:

A new approach to anion sensing that involves excimer disaggregation induced emission (EDIE) is reported. It involves the anion-mediated disaggregation of the excimer formed from a cationic macrocycle. This leads to an increase in the observed fluorescence intensity. The macrocycle in question, cyclo[1]N2,N6-dimethyl-N2,N6-bis(6-(1H-imidazolium-1-yl)pyridin-2-yl)pyridine-2,6-diamine[1]1,4-dimethylbenzene (12+; prepared as its PF6- salt), is obtained in ca. 70% yield via a simple cyclization. X-ray diffraction analyses of single crystals revealed that, as prepared, this macrocycle exists in a supramol. polymeric form in the solid state. Macrocycle 12+ is weakly fluorescent in acetonitrile. The emission intensity is concentration dependent, with the maximum intensity being observed at [12+] ≈ 0.020 mM. This finding is ascribed to formation of an excimer, followed possibly by higher order aggregates as the concentration of 12+ is increased. Addition of tetrabutylammonium pyrophosphate (HP2O73-) to 12+ (0.020 mM in acetonitrile) produces a ca. 200-fold enhancement in the emission intensity (λex = 334 nm; λem = 390-650 nm). These findings are rationalized in terms of the HP2O73- serving to break up essentially non-fluorescent excited-state dimers of 12+ through formation of a highly fluorescent anion-bound monomeric complex, 12+·HP2O73-. A turn-on in the fluorescence intensity is also seen for H2PO4- and, to a lesser extent, HCO3-. Little (HSO4-, NO3-) or essentially no (N3-, SCN-, F-, Cl-, Br- and I-) response is seen for other anions. Solid-state structural anal. of single crystals obtained after treating 12+ with HP2O73- in the presence of water revealed a salt form wherein a H2P2O72- anion sits above the cone-like macrocycle. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Safety of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A bis-acridinium macrocycle as multi-responsive receptor and selective phase-transfer agent of perylene》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Hu, Johnny; Ward, Jas S.; Chaumont, Alain; Rissanen, Kari; Vincent, Jean-Marc; Heitz, Valerie; Jacquot de Rouville, Henri-Pierre. Application In Synthesis of 2,6-Dibromopyridine The article mentions the following:

A bis-acridinium cyclophane incorporating switchable acridinium moieties linked by a 3,5-dipyridylanisole spacer was studied as a multi-responsive host for polycyclic aromatic hydrocarbon guests. Complexation of perylene was shown to be the most effective and was characterized in particular by a charge-transfer band as signal output. Effective catch and release of the guest was triggered by both chem. (proton/hydroxide) and redox stimuli. Moreover, the dicationic host was also easily switched between organic and perfluorocarbon phases for applications related to the enrichment of perylene from a mixture of polycyclic aromatic hydrocarbons. In the experiment, the researchers used 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

McConnell, Danielle L.; Blades, Alisha M.; Rodrigues, Danielle Gomes; Keyes, Phoebe V.; Sonberg, Justin C.; Anthony, Caitlin E.; Rachad, Sofia; Simone, Olivia M.; Sullivan, Caroline F.; Shapiro, Jonathan D.; Williams, Christopher C.; Schafer, Benjamin C.; Glanzer, Amy M.; Hutchinson, Holly L.; Thayaparan, Ashley B.; Krevlin, Zoe A.; Bote, Isabella C.; Haffary, Yasin A.; Bhandari, Sambat; Goodman, Jack A.; Majireck, Max M. published an article in 2021. The article was titled 《Synthesis of Bench-Stable N-Quaternized Ketene N,O-Acetals and Preliminary Evaluation as Reagents in Organic Synthesis》, and you may find the article in Journal of Organic Chemistry.Category: pyridine-derivatives The information in the text is summarized as follows:

In this report, a general synthetic approach to a variety of bench-stable N-quaternized ketene N,O-acetals I (R = H, 2-Ph, 4-Me, 2,6-Cl2, etc.; X = OTf, NTf2) via treatment of pyridine II or aniline bases with acetylenic ethers R1CC (R1 = OEt, 4-methoxyphenyl) and an appropriate Bronsted or Lewis acid (triflic acid, triflimide, or scandium(III) triflate) have been described. The resulting pyridinium I and anilinium salts C6H5N+((CH3)CH2)C(=CH2)R1 X- can be used as reagents or synthetic intermediates in multiple reaction types. For example, N-(1-ethoxyvinyl)pyridinium or anilinium salts can thermally release highly reactive O-Et ketenium ions for use in acid catalyst-free electrophilic aromatic substitutions. N-(1-ethoxyvinyl)-2-halopyridinium salts I (R = 2-Cl, 2-Br) can be employed in peptide couplings as a derivative of Mukaiyama reagent (2-chloro-1-methylpyridinium iodide) or react with phenylmethanamine in nucleophilic aromatic substitutions under mild conditions. These preliminary reactions illustrate the broad potential of these currently understudied compounds in organic synthesis. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《On-Surface Synthesis of Giant Conjugated Macrocycles》 was published in Angewandte Chemie, International Edition. The article was written by Fan, Cunrui; Sun, Bangjin; Li, Zhanbo; Shi, Jiwei; Lin, Tao; Fan, Jian; Shi, Ziliang. The article contains the following contents:

We have achieved an on-surface synthesis of giant conjugated macrocycles having a diameter of ≈7 nm and consisting of up to 30 subunits. The synthesis started with a debrominative coupling of the mol. precursors on a hot Ag(111) surface, leading to the formation of arched oligomeric chains and macrocycles. These products were revealed by scanning tunneling microscopy in combination with d. functional theory to be covalent oligomers. These intermediates also display C-Ag organometallic bonds between parallel mol. subunits due to site-selective debromination and the asym. mol. conformation. Subsequent cyclodehydrogenation at higher temperatures steered the final conjugation of the macrocycles. Our findings provide a novel design strategy toward π-conjugated macrocycles and open up new opportunities for the precise synthesis of organic nanostructures. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Dalton Transactions included an article by Jacquot de Rouville, Henri-Pierre; Gourlaouen, Christophe; Heitz, Valerie. Category: pyridine-derivatives. The article was titled 《Self-complementary and narcissistic self-sorting of bis-acridinium tweezers》. The information in the text is summarized as follows:

A mol. tweezer incorporating two acridinium moieties linked by a 1,3-dipyridylbenzene spacer was synthesized in three steps. The formation of its self-complementary dimer in water was demonstrated as a result of π-π stacking and hydrophobic interactions. Moreover, a 1 : 1 mixture of this bis-acridinium tweezer with one built on a 2,6-diphenylpyridyl spacer evidenced its narcissistic self-sorting behavior in water. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Diiminepyridine-Supported Phosphorus(I) and Phosphorus(III) Complexes: Synthesis, Characterization, and Electrochemistry》 was written by Gray, Paul A.; Braun, Jason D.; Rahimi, Naser; Herbert, David E.. Recommanded Product: 626-05-1 And the article was included in European Journal of Inorganic Chemistry in 2020. The article conveys some information:

Diiminepyridines (DIP) are popular redox noninnocent ligands with widespread application in late, 1st-row transition metal mediated catalysis and coordination chem. Here, the authors report the isolation and characterization of a pair of P coordination complexes in the +1 and +3 oxidation states supported by the same ligand framework bearing sterically imposing and electron-releasing tBu substituents on the imine carbons of the DIP backbone. Electrochem. anal. demonstrates that the DIP scaffold can retain its ability to serve as an electron reservoir when coordinated to a reduced pnicogen center, with a reversible reduction observed for the PI complex. The experimental process involved the reaction of 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattarai, Rajan Sharma; Kumar, Virender; Romanova, Svetlana; Bariwal, Jitender; Chen, Hao; Deng, Shanshan; Bhatt, Vijaya R.; Bronich, Tatiana; Li, Wei; Mahato, Ram I. published an article in 2021. The article was titled 《Nanoformulation design and therapeutic potential of a novel tubulin inhibitor in pancreatic cancer》, and you may find the article in Journal of Controlled Release.HPLC of Formula: 626-05-1 The information in the text is summarized as follows:

Successful treatment of pancreatic cancer remains a challenge due to desmoplasia, development of chemoresistance, and systemic toxicity. Herein, we synthesized (6-(3-hydroxy-4-methoxylphenyl)pyridin-2-yl) (3,4,5-trimethoxyphenyl)methanone (CH-3-8), a novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance. CH-3-8 binding to the colchicine-binding site in tubulin protein was confirmed by tubulin polymerization assay and mol. modeling. CH-3-8 disrupted microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancreatic cancer cell lines. CH-3-8 significantly inhibited the proliferation of these cells, induced G2/M cell cycle arrest, and led to apoptosis. CH-3-8 is hydrophobic with an aqueous solubility of 0.97 ± 0.16 μg/mL at pH 7.4. We further conjugated it with dodecanol through diglycolate linker to increase hydrophobicity and thus loading in lipid-based delivery systems. Hence, we encapsulated CH-3-8 lipid conjugate (LDC) into methoxy poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (mPEG-b-PCC-g-DC) polymeric nanoparticles (NPs) by solvent evaporation, resulting in a mean particle size of 125.6 ± 2.3 nm and drug loading of 10 ± 1.0% (weight/weight) while the same polymer could only load 1.6 ± 0.4 (weight/weight) CH-3-8 using the same method. Systemic administration of 6 doses of CH-3-8 and LDC loaded NPs at the dose of 20 mg/kg into orthotopic pancreatic tumor-bearing NSG mice every alternate day resulted in significant tumor regression. Systemic toxicity was negligible, as evidenced by histol. evaluations. In conclusion, CH-3-8 LDC loaded NPs have the potential to improve outcomes of pancreatic cancer by overcoming transporter-mediated chemoresistance and reducing systemic toxicity. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of the American Chemical Society included an article by Chi, Xiaodong; Cen, Wanglai; Queenan, Jack A.; Long, Lingliang; Lynch, Vincent M.; Khashab, Niveen M.; Sessler, Jonathan L.. Category: pyridine-derivatives. The article was titled 《Azobenzene-Bridged Expanded “”Texas-sized”” Box: A Dual-Responsive Receptor for Aryl Dianion Encapsulation》. The information in the text is summarized as follows:

We report an expanded “”Texas-sized”” mol. box (AzoTxSB) that incorporates photoresponsive azobenzene bridging subunits and anion recognition motifs. The shape of this box can be switched through light induced E ↔ Z photoisomerization of the constituent azobenzenes. This allows various anionic substrates to be bound and released by using different forms of the box. Control can also be achieved using other environmental stimuli, such as pH and anion competition. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Versatile Coordination Modes of 2,6-Bis(2-(diphenylphosphanyl)-1H-imidazol-1-yl)pyridine in Cu(I) and Au(I) Complexes》 was published in European Journal of Inorganic Chemistry in 2020. These research results belong to Kumar, Saurabh; Mague, Joel T.; Balakrishna, Maravanji S.. Category: pyridine-derivatives The article mentions the following:

Synthesis, and copper(I) and gold(I) complexes of imidazole-based bisphosphine, [2,6-(PPh2C3H2N2)2C5H3N] are described. Reactions of [2,6-(PPh2C3H2N2)2C5H3N] with one equivalent of CuX (X = Cl, Br or I) yielded either monomeric [{2,6-{PPh2C3H2N2}2C5H3N}{CuI}], dimeric [[PPh2C3H2N2]2(C5H3N)(CuCl)2], or one-dimensional (1D) polymeric [{2,6-(PPh2-C3H2N2)2C5H3N}{Cu3Br2}]nCl complexes. Coordination polymer [{2,6-(PPh2C3H2N2)2C5H3N}{Cu3Br2}]nCl is a rare example containing alternately arranged copper atoms having tetrahedral and linear geometries. The repeating unit consists of imidazolyl nitrogen atoms from two ligands bind to a copper atom in a linear fashion, whereas two phosphorus atoms from the same ligand are chelated to a tetrahedral copper atom, thus ligand displaying tetradentate behavior. Treatment of bisphosphine with two equivalent of [AuCl(SMe2)] yielded digold complex [2,6-(PPh2C3H2N2)2C5H3N{AuCl}2]. The structures of most of these compounds were confirmed by single-crystal X-ray analyses. These complexes show good photoluminescence properties as well. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem