Category: 626-05-1

《New antiparasitic flexible triaryl diamidines, their prodrugs and aza analogues: Synthesis, in vitro and in vivo biological evaluation, and molecular modelling studies》 was written by Arafa, Reem K.; Ismail, Mohamed A.; Wenzler, Tanja; Brun, Reto; Paul, Ananya; Wilson, W. David; Alakhdar, Amira A.; Boykin, David W.. Recommanded Product: 2,6-DibromopyridineThis research focused ontriaryl diamidine prodrug preparation SAR antimalarial antitrypanosomal; Antimalarial; Antitrypanosomal; Flexible diamidines; Minor groove binders; Molecular dynamics; Triaryl dications. The article conveys some information:

Dicationic diamidines have been well established as potent antiparasitic agents with proven activity against tropical diseases like trypanosomiasis and malaria. This work presents the synthesis of new mono and diflexible triaryl amidines their aza analogs and resp. methoxyamidine prodrugs. All diamidines were assessed in vitro against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) where they displayed potent to moderate activities at the nanomolar level with IC50s = 11 – 378 nM for T. b. r. and 4 – 323 nM against P. f.. In vivo efficacy testing against T. b. r. STIB900 has shown the monoflexible diamidine 2-(4′-Amidinophenyl)-5-(4”-amidinobenzyl)pyridine acetate salt as the most potent derivative in this study eliciting 4/4 cures of infected mice for a treatment period of >60 days upon a 4 x 5 mg/kg dose i. p. treatment. Moreover, thermal melting anal. measurement ΔTm for this series of diamidines/poly (dA-dT) complexes fell between 0.5 and 19° with the above compound showing the highest binding to the DNA minor groove. Finally, a 50 ns mol. dynamics study of an AT-rich DNA dodecamer with the above compound revealed a strong binding complex supported by vdW and electrostatic interactions. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 626-05-1In 2021 ,《Syntheses and Physical Properties of Cationic BN-Embedded Polycyclic Aromatic Hydrocarbons》 appeared in Angewandte Chemie, International Edition. The author of the article were Gotoh, Hajime; Nakatsuka, Soichiro; Tanaka, Hiroki; Yasuda, Nobuhiro; Haketa, Yohei; Maeda, Hiromitsu; Hatakeyama, Takuji. The article conveys some information:

Cationic BN-embedded polycyclic aromatic hydrocarbons (BN-PAH+s) were synthesized from a N-containing macrocycle via pyridine-directed tandem C-H borylation. Incorporating BN into PAH+ resulted in a remarkable hypsochromic shift due to an increase in the LUMO energy and the symmetry changes of the HOMO and LUMO. Electrophilic substitution or anion exchange of BN-PAH+ possessing tetrabromoborate as a counteranion (BN+[BBr4-]) afforded air-stable BN-PAH/PAH+s. Of these, BN+[TfO-] allowed reversible two-electron reduction and the formation of two-dimensional brickwork-type π-electronic ion pair with 1,2,3,4,5-pentacyanocyclopentadienyl anion, demonstrating the potential application of BN-PAH+ as electronic materials. In the experiment, the researchers used 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Cheng, Heyong; Yang, Tingyuan; Edwards, Madison; Tang, Shuli; Xu, Shiqing; Yan, Xin published an article in Journal of the American Chemical Society. The title of the article was 《Picomole-Scale Transition Metal Electrocatalysis Screening Platform for Discovery of Mild C-C Coupling and C-H Arylation through in Situ Anodically Generated Cationic Pd》.Recommanded Product: 626-05-1 The author mentioned the following in the article:

Development of new transition metal-catalyzed electrochem. promises to improve overall synthetic efficiency. Here the authors describe the 1st integrated platform for online screening of electrochem. transition-metal catalysis. It uses the intrinsic electrochem. capabilities of nanoelectrospray ionization mass spectrometry (nano-ESI-MS) and picomole-scale anodic corrosion of a Pd electrode to generate and evaluate highly efficient cationic catalysts for mild electrocatalysis. The authors demonstrate the power of the novel electrocatalysis platform by (1) identifying electrolytic Pd-catalyzed Suzuki coupling at room temperature, (2) discovering Pd-catalyzed electrochem. C-H arylation in the absence of external oxidant or additive, (3) developing electrolyzed Suzuki coupling/C-H arylation cascades, and (4) achieving late-stage functionalization of two drug mols. by the newly developed mild electrocatalytic C-H arylation. More importantly, the scale-up reactions confirm that new electrochem. pathways discovered by nano-ESI can be implemented under the conventional electrolytic reaction conditions. This approach enables in situ mechanistic studies by capturing various intermediates including transient transition metal species by MS, and thus uncovering the critical role of anodically generated cationic Pd catalyst in promoting otherwise sluggish transmetalation in C-H arylation. The anodically generated cationic Pd with superior catalytic efficiency and novel online electrochem. screening platform hold great potentials for discovering mild transition-metal-catalyzed reactions. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,6-DibromopyridineIn 2021 ,《Electronic Properties of Rhenium(I) Carbonyl Complexes Bearing Strongly Donating Hexahydro-Pyrimidopyrimidine Based Ligands》 appeared in European Journal of Inorganic Chemistry. The author of the article were Auvray, Thomas; Pal, Amlan K.; Hanan, Garry S.. The article conveys some information:

Re(I) tricarbonyl complexes were synthesized using bi- and tridentate ligands equipped with one or two hexahydro-pyrimidopyrimidine (hpp) units attached to either a pyridine or a pyrazine ring. These complexes were characterized by NMR, ESI-MS, vibrational and optical spectroscopies as well as electrochem. Their structures were determined via single-crystal x-ray crystallog. and modelled using both DFT and TD-DFT methods. The complexes are non-emissive in solution at room temperature but display emission with mixed intra ligand (major) and metal-ligand (minor) charge transfer characters at 77 K. Addnl., both pyrazine-based complexes appear to be emissive in the solid state, presumably due to the presence of intermol. interactions, as observed in the crystal structure. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Beilstein Journal of Organic Chemistry included an article by Kennedy, Sean H.; Gasonoo, Makafui; Klumpp, Douglas A.. Recommanded Product: 2,6-Dibromopyridine. The article was titled 《Superelectrophilic carbocations: preparation and reactions of a substrate with six ionizable groups》. The information in the text is summarized as follows:

A substrate was prepared having two triarylmethanol centers and four pyridine-type substituent groups. Upon ionization in Bronsted superacid CF3SO3H, the substrate underwent two types of reactions. In presence of only the superacid, highly ionized intermediate(s) provided a double cyclization product having two pyrido[1,2-a]indole rings I. With added benzene, an arylation product II was obtained. A mechanism was proposed involving tetra-, penta-, or hexacationic species. In addition to this study using 2,6-Dibromopyridine, there are many other studies that have used 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Clarke, Coby J.; Morgan, Patrick J.; Hallett, Jason P.; Licence, Peter published an article in 2021. The article was titled 《Linking the the Thermal and Electronic Properties of Functional Dicationic Salts with their Molecular Structures》, and you may find the article in ACS Sustainable Chemistry & Engineering.HPLC of Formula: 626-05-1 The information in the text is summarized as follows:

The two major properties that underpin ionic liquids are tunability and the potential to create task-specific media. Together, these properties allow ionic liquids to surpass the roles long held by traditional mol. solvents. However, at elevated temperatures or under prolonged heating, the structural components that impart such properties decompose or degrade. Dicationic pyridine salts present new opportunities to extend functionality and tunability to high temperatures because they are coordinating and thermally robust. In this work, we present three structurally related series of dicationic pyridine salts, which have been characterized by a wide array of techniques to link thermal and electronic properties to structural variation. The phase transitions and thermal stabilities of the salts were significantly influenced by small structural changes, and several new candidates for high-temperature-based applications were identified. The electron d., and therefore the electron donating ability, of the pyridine functional group could also be controlled by structural variation of cations and anions. Therefore, dicationic pyridine salts are highly tunable choices for task-specific solvents at elevated temperatures Importantly, thermally robust solvents not only extend operational ranges but also reduce the need to replace or replenish solvents that degrade over time at temperatures commonly employed in industrial settings (i.e., 150-200°C); solvent lifetimes are extended, and production is reduced. This is a critical requirement for complex media such as ionic liquids, which have high economic and environmental production costs. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Halogen Bonding Helicates Encompassing Iodonium Cations》 were Vanderkooy, Alan; Gupta, Arvind Kumar; Foeldes, Tamas; Lindblad, Sofia; Orthaber, Andreas; Papai, Imre; Erdelyi, Mate. And the article was published in Angewandte Chemie, International Edition in 2019. SDS of cas: 626-05-1 The author mentioned the following in the article:

The first halonium-ion-based helixes were designed and synthesized using oligo-aryl/pyridylene-ethynylene backbones that fold around reactive iodonium ions. Halogen bonding interactions stabilize the iodonium ions within the helixes. Remarkably, the distance between two iodonium ions within a helix is shorter than the sum of their van der Waals radii. The helical conformations were characterized by X-ray crystallog. in the solid state, by NMR spectroscopy in solution and corroborated by DFT calculations The helical complexes possess potential synthetic utility, as demonstrated by their ability to induce iodocyclization of 4-penten-1-ol. In the experiment, the researchers used 2,6-Dibromopyridine(cas: 626-05-1SDS of cas: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Development and validation of a mass spectrometry binding assay for mGlu5 receptor》 was written by Ricart-Ortega, Maria; Berizzi, Alice E.; Catena, Juanlo; Malhaire, Fanny; Munoz, Lourdes; Serra, Carmen; Lebon, Guillaume; Goudet, Cyril; Llebaria, Amadeu. Name: 2,6-Dibromopyridine And the article was included in Analytical and Bioanalytical Chemistry in 2020. The article conveys some information:

Abstract: Mass spectrometry (MS) binding assays are a label-free alternative to radioligand or fluorescence binding assays, so the readout is based on direct mass spectrometric detection of the test ligand. The study presented here describes the development and validation of a highly sensitive, rapid, and robust MS binding assay for the quantification of the binding of the metabotropic glutamate 5 (mGlu5) neg. allosteric modulator (NAM), MPEP (2-methyl-6-phenylethynylpyridine) at the mGlu5 allosteric binding site. The LC-ESI-MS/MS (liquid chromatog.-electrospray ionization-tandem mass spectrometric) anal. method was established and validated with a deuterated analog of MPEP as an internal standard The developed MS binding assay described here allowed for the determination of MS binding affinity estimates that were in agreement with affinity estimates obtained from a tritiated MPEP radioligand saturation binding assay, indicating the suitability of this methodol. for determining affinity estimates for compounds that target mGlu5 allosteric binding sites. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Name: 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Antoni, Patrick W.; Golz, Christopher; Hansmann, Max M. published an article in Angewandte Chemie, International Edition. The title of the article was 《Organic Four-Electron Redox Systems Based on Bipyridine and Phenanthroline Carbene Architectures》.Safety of 2,6-Dibromopyridine The author mentioned the following in the article:

Novel organic redox systems that display multistage redox behavior are highly sought-after for a series of applications such as organic batteries or electrochromic materials. Here we describe a simple strategy to transfer well-known two-electron redox active bipyridine and phenanthroline architectures into novel strongly reducing four-electron redox systems featuring fully reversible redox events with up to five stable oxidation states. We give spectroscopic and structural insight into the changes involved in the redox-events and present characterization data on all isolated oxidation states. The redox-systems feature strong UV/Vis/NIR polyelectrochromic properties such as distinct strong NIR absorptions in the mixed valence states. Two-electron charge-discharge cycling studies indicate high electrochem. stability at strongly neg. potentials, rendering the new redox architectures promising lead structures for multi-electron anolyte materials. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dibromopyridine(cas: 626-05-1Safety of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Safety of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Voelkel, Martin H. H.; Engelage, Elric; Kondratiuk, Mykhailo; Huber, Stefan M. published an article in European Journal of Organic Chemistry. The title of the article was 《Evaluation of 6-Halogenated 2-Pyridone Moieties as Halogen Bond Donors》.Safety of 2,6-Dibromopyridine The author mentioned the following in the article:

6-Halo-2-pyridones and their pyridol tautomers show different grades of polarization on their halogen substituents in DFT calculations This and the fact that the tautomeric equilibrium was affected by the surrounding medium make them interesting candidates for a new platform of halogen bond donors. Therefore four simple halopyridones was probed for their halogen bonding properties both in the solid state and in solution Concurring with hydrogen bonding, halogen bonding indeed was found to be an interaction governing the packing motif in pyridone crystals, which was more pronounced in N-methylated congeners. Solution studies using a halide abstraction reaction and NMR titrations against bromide salts, however, showed no clear evidence for halogen bonding in solution After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Safety of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem