Category: 626-55-1

Related Products of 626-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-55-1, name is 3-Bromopyridine, molecular formula is C5H4BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 3.54 g of diisopropylamine and 50 ml of tetrahydrofuran was stirred while cooling in a dry ice-acetone bath. To the reaction mixture, 20 ml of 1.6 M hexane solution of n-butyllithium was added so that the temperature of the reaction mixture did not exceed -40C. The reaction mixture was stirred for 30 minutes. Then, a mixture of 4.74 g of 3-bromopyridine and 5 ml of tetrahydrofuran was added so that the temperature of the reaction mixture did not exceed -60C. The reaction mixture was stirred for further 30 minutes. Crushed dry ice was added to the reaction mixture and then cooling was stopped. The reaction mixture was stirred until the temperature retuned to room temperature. Water was added thereto, most of hexane and tetrahydrofuran was removed under reduced pressure. The residue was washed with tert-butyl methyl ether, and the aqueous layers were collected. To the collected aqueous layers, concentrated hydrochloric acid was added while ice- cooling so that pH of the mixture was made to be 3 and stirred for one hour, followed by extraction with ethyl acetate three times. The combined organic layers were washed with a saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 0.69 g of 3-bromo isonicotinic acid.-NMR (DMSO-d6) delta: 8.74 (s, 1H), 8.67 (d, J=4.9 Hz, 1H), 7.69 (d, J=4.9 Hz, 1H)

According to the analysis of related databases, 626-55-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; OTSUKI, Junko; WO2011/49221; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 626-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-55-1, name is 3-Bromopyridine, molecular formula is C5H4BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 3.54 g of diisopropylamine and 50 ml of tetrahydrofuran was stirred while cooling in a dry ice-acetone bath. To the reaction mixture, 20 ml of 1.6 M hexane solution of n-butyllithium was added so that the temperature of the reaction mixture did not exceed -40C. The reaction mixture was stirred for 30 minutes. Then, a mixture of 4.74 g of 3-bromopyridine and 5 ml of tetrahydrofuran was added so that the temperature of the reaction mixture did not exceed -60C. The reaction mixture was stirred for further 30 minutes. Crushed dry ice was added to the reaction mixture and then cooling was stopped. The reaction mixture was stirred until the temperature retuned to room temperature. Water was added thereto, most of hexane and tetrahydrofuran was removed under reduced pressure. The residue was washed with tert-butyl methyl ether, and the aqueous layers were collected. To the collected aqueous layers, concentrated hydrochloric acid was added while ice- cooling so that pH of the mixture was made to be 3 and stirred for one hour, followed by extraction with ethyl acetate three times. The combined organic layers were washed with a saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 0.69 g of 3-bromo isonicotinic acid.-NMR (DMSO-d6) delta: 8.74 (s, 1H), 8.67 (d, J=4.9 Hz, 1H), 7.69 (d, J=4.9 Hz, 1H)

According to the analysis of related databases, 626-55-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; OTSUKI, Junko; WO2011/49221; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 626-55-1, Name is 3-Bromopyridine, formurla is C5H4BrN. In a document, author is Yang, Hai-Long, introducing its new discovery. Computed Properties of C5H4BrN.

A bi-component supramolecular gel for selective fluorescence detection and removal of Hg2+ in water

A bi-component supramolecular gel (RQ) was successfully constructed by the assembly of the gelators 4-aminophenyl functionalized naphthalimide derivative (R) and tri-(pyridine-4-yl)-functionalized trimesic amide (Q) in DMSO-H2O (6.1:3.9, v/v) binary solution. The gel RQ exhibits excellent self-healing capacity. Interestingly, the RQ could fluorescently detect and reversibly remove Hg2+ from water through cation-pi interactions with high selectivity, efficient adsorption and quick response. The limit of lowest detection (LOD) of the RQ for Hg2+ is 4.52 x 10(-8) M and the separation ratio is 91.14%. Moreover, the RQ could be efficiently recycled and regenerated with little loss via a simple treatment by I-. Notably, thin films based on RQ and RQ + Hg2+ were prepared, which could serve as convenient and efficient test tools for the detection of Hg2+ and I-, respectively. This work provided an efficient method and novel supramolecular gel material for the separation and detection of Hg2+.

If you are hungry for even more, make sure to check my other article about 626-55-1, Computed Properties of C5H4BrN.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 626-55-1, Name is 3-Bromopyridine, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Leyva, Elisa, Quality Control of 3-Bromopyridine.

Identification of intermediate compounds and photodegradation mechanisms of omeprazole under the system UV/O-2

The photodegradation of the proton pump inhibitor omeprazole (OME) in aqueous media with the system UV/O-2 is presented. The photodegradation rate was assessed by HPLC and UV-vis spectroscopy, while the mineralization rate was obtained by TOC measurements. Degradation products were investigated by IR spectroscopy and GC-MS analysis. UV-vis absorbance and HPLC results indicated that OME is completely degraded within 3 minutes of irradiation. TOC analysis indicated that intermediates compounds are relatively easy to mineralize since 80% mineralization is achieved within 2 hours. IR studies demonstrated a rapid oxidation of OME leading to the formation of amines and both sulfonic and carboxylic acids. GC-MS data indicated that the initial photoproducts are derivatives of both benzimidazole and pyridine produced after the photochemical cleavage of the C-S bond. Plausible mechanisms for the direct and indirect degradation of OME are given. In the photochemical degradation of OME, many intermediate compounds are actually generated. Several of them were generated from hydroxyl radical reactions, but some of them resulted from rearrangements, reductive reactions, and through the formation of highly reactive intermediates such as pseudo carbene, thiooxirane, and sulfenamide.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 626-55-1, in my other articles. Quality Control of 3-Bromopyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 626-55-1, Name is 3-Bromopyridine, molecular formula is C5H4BrN. In an article, author is Astakhov, Alexander, V,once mentioned of 626-55-1, Application In Synthesis of 3-Bromopyridine.

Relative stabilities of M/NHC complexes (M = Ni, Pd, Pt) against R-NHC, X-NHC and X-X couplings in M(0)/M(ii) and M(ii)/M(iv) catalytic cycles: a theoretical study

The complexes of Ni, Pd, and Pt with N-heterocyclic carbenes (NHCs) catalyze numerous organic reactions via proposed typical M-0/M-II catalytic cycles comprising intermediates with the metal center in (0) and (II) oxidation states. In addition, M-II/M-IV catalytic cycles have been proposed for a number of reactions. The catalytic intermediates in both cycles can suffer decomposition via R-NHC coupling and the side reductive elimination of the NHC ligand and R groups (R = alkyl, aryl, etc.) to give [NHC-R](+) cations. In this study, the relative stabilities of (NHC)M-II(R)(X)L and (NHC)M-IV(R)(X)(3)L intermediates (X = Cl, Br, I; L = NHC, pyridine) against R-NHC coupling and other decomposition pathways via reductive elimination reactions were evaluated theoretically. The study revealed that the R-NHC coupling represents the most favorable decomposition pathway for both types of intermediates (M-II and M-IV), while it is thermodynamically and kinetically more facile for the M-IV complexes. The relative effects of the metal M (Ni, Pd, Pt) and ligands L and X on the R-NHC coupling for the M-IV complexes were significantly stronger than that for the M-II complexes. In particular, for the (NHC)(2)M-IV(Ph)(Br)(3) complexes, Ph-NHC coupling was facilitated dramatically from Pt (Delta G = -36.9 kcal mol(-1), Delta G(not equal) = 37.5 kcal mol(-1)) to Pd (Delta G = -61.5 kcal mol(-1), Delta G(not equal) = 18.3 kcal mol(-1)) and Ni (Delta G = -80.2 kcal mol(-1), Delta G(not equal) = 4.7 kcal mol(-1)). For the M-II oxidation state of the metal, the bis-NHC complexes (L = NHC) were slightly more kinetically and thermodynamically stable against R-NHC coupling than the mono-NHC complexes (L = pyridine). An inverse relation was observed for the M-IV oxidation state of the metal as the (NHC)(2)M-IV(R)(X)(3) complexes were kinetically (4.3-15.9 kcal mol(-1)) and thermodynamically (8.0-23.2 kcal mol(-1)) significantly less stable than the (NHC)M-IV(R)(X)(3)L (L = pyridine) complexes. For the Ni-IV and Pd-IV complexes, additional decomposition pathways via the reductive elimination of the NHC and X ligands to give the [NHC-X](+) cation (X-NHC coupling) or reductive elimination of the X-X molecule were found to be thermodynamically and kinetically probable. Overall, the obtained results demonstrate significant instability of regular Ni/NHC and Pd/NHC complexes (for example, not additionally stabilized by chelation) and high probability to initiate NHC-free catalysis in the reactions comprising M-IV intermediates.

If you¡¯re interested in learning more about 626-55-1. The above is the message from the blog manager. Application In Synthesis of 3-Bromopyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 626-55-1, Name is 3-Bromopyridine, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Yang, Siwei, HPLC of Formula: C5H4BrN.

Graphene Quantum Dots with Pyrrole N and Pyridine N: Superior Reactive Oxygen Species Generation Efficiency for Metal-Free Sonodynamic Tumor Therapy

Those responsible for the development of sonosensitizers are faced with a dilemma between high sonosensitization efficacy and good biosecurity that limited the development of sonodynamic therapy (SDT). Herein, inspired by the intriguing therapeutic features of SDT and the potential catalytic activity of graphene quantum dots, the potential of N-doped graphene quantum dots (N-GQDs) to act as a sonosensitizer is demonstrated. The superior sonosensitization effect of N-GQDs is believed to be three to five times higher than that of traditional sonosensitizers (such as porphyrin, porphyrin Mn, porphyrin Zn, TiO2, etc.). More importantly, the sonochemical mechanism of N-GQDs is revealed. Pyrrole N and pyridine N are believed to form catalytic centers in sonochemical processing of N-GQDs. This knowledge is important from the perspective of understanding the structure-dependent SDT enhancement of carbon nanostructure. Moreover, N-GQDs modified by folic acid (FA-N-GQDs) show a high marker rate for tumor cells (greater than 96%). Both in vitro and in vivo therapeutic results have exhibited high tumor inhibition efficiency (greater than 90%) of FA-N-GQDs as sonosensitizers while the oxidative stress response of tumor cells is activated through the PEX pathway and induced apoptosis via the p53 pathway.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 626-55-1, in my other articles. HPLC of Formula: C5H4BrN.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, Category: pyridine-derivatives, begins with the direct observation of nature¡ª in this case, of matter.626-55-1, Name is 3-Bromopyridine, SMILES is BrC1=CC=CN=C1, belongs to pyridine-derivatives compound. In a document, author is Xu, Songgen, introduce the new discover.

Iron Catalyzed Isomerization of alpha-Alkyl Styrenes to Access Trisubstituted Alkenes

Main observation and conclusion Stereoselective isomerization of alpha-alkyl styrenes is accomplished using a new iron catalyst supported by phosphine-pyridine-oxazoline (PPO) ligand. The protocol provides an atom-efficient and operationally simple approach to trisubstituted alkenes in high yields with excellent regio- and stereoselectivities under mild conditions. The results of deuterium-labelling and radical trap experiments are consistent with an iron-hydride pathway involving reversible alkene insertion and beta-H elimination.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 626-55-1. Category: pyridine-derivatives.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application of 626-55-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 626-55-1, Name is 3-Bromopyridine, SMILES is BrC1=CC=CN=C1, belongs to pyridine-derivatives compound. In a article, author is Wang, Jing, introduce new discover of the category.

Nitrate stimulation of N-Methylpyrrolidone biodegradation by Paracoccus pantotrophus: Metabolite mechanism and Genomic characterization

Due to the toxicological nature of N-methylpyrrolidone (NMP), the conventional anaerobic bioprocess is quite ineffective for NMP removal from wastewater. In order to achieve effective NMP biodegradation under anoxic condition, Paracoccus pantotrophus NJUST38 was isolated for the first time. The supplementation of nitrate into anoxic system resulted in complete removal of 5mM NMP by NJUST38 within 11 h compared to 24% in the anaerobic control system in the absence of nitrate. Genome characterization revealed that NMP biodegradation catalyzed by several key enzymes/genes, including N-methylhydantoin amidohydrolase (hyuB), methyltransferase (cobA), 4-aminobutyrate-2-oxoglutarate transaminase (gabT), succinate-semialdehyde dehydrogenase (gabD) and so on. NMP biodegradation pathway was proposed based on several intermediates, where NMP was biodegraded mainly for providing electrons and reducing power to support microbial denitrification through tricarboxylic acid (TCA) cycle. The proposed mechanism should aid our mechanistic understanding of NMP biodegradation by Paracoccus pantotrophus and the development of sustainable bioremediation strategies.

Application of 626-55-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 626-55-1 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 626-55-1, Name is 3-Bromopyridine, molecular formula is C5H4BrN, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Camuenho, Ambrosio, once mentioned the new application about 626-55-1, Application In Synthesis of 3-Bromopyridine.

A model compound for pyridinechalcone-based multistate systems. Ring opening-closure as the slowest kinetic step of the multistate

Anthocyanins and related flavylium derivatives exist in aqueous solution as a pH-dependent mole fraction distribution of species (a multistate system) with known biological activity. Introduction of nitrogen heterocycles in the flavylium core can lead to multistates with different constitution and increased activity. Compound 1, a diethylamino derivative of 4-pyridinechalcone, was synthesized and characterized by X-ray crystallography, showing a pH-dependent reaction network similar to anthocyanins and related compounds. The several species present at the equilibrium multistate were fully characterized by H-1 NMR and C-13 NMR. The thermodynamics and kinetics of the multistate were studied through pH jumps followed by H-1 NMR and UV-vis absorption including stopped-flow for the faster kinetic steps. In the parent 4-pyridinechalcone compound, protonation of the pyridine nitrogen for pH < 4 prevents formation of the flavylium cation. In compound 1, the first protonation takes place in the diethylamino substituent and in acidic medium, two new flavylium derivatives, a single (2 < pH < 4) and a double (pH < 1) positively charged species, in equilibrium with protonated hemiketal, cis and trans chalcones, have been characterized. Differently from anthocyanins and related compounds, experimental evidence for an unexpected very slow (0.0003 s(-1)) ring opening-closure between the hemiketal and the cis-chalcone (tautomerization) was achieved. We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 626-55-1. The above is the message from the blog manager. Application In Synthesis of 3-Bromopyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, SDS of cas: 626-55-1, begins with the direct observation of nature¡ª in this case, of matter.626-55-1, Name is 3-Bromopyridine, SMILES is BrC1=CC=CN=C1, belongs to pyridine-derivatives compound. In a document, author is Wu, Zhen-Yi, introduce the new discover.

Terpyridine-containing porphyrin and coordination assembly with fullerene-based pyridine for enhanced electrocatalytic oxygen evolution and photocurrent response

A novel terpyridine-modified porphyrin, ZnP-Pr-tpy, has been synthesized and characterized successfully using elemental analysis, mass spectrometry (MS), nuclear magnetic resonance spectroscopy (NMR), infrared spectroscopy (IR) and ultraviolet/visible spectroscopy (UV-Vis). Studies by steady-state fluorescence and UV-visible spectroscopies show that a supramolecular dyad is formed by fullerene-based pyridine (C-60-py) and the zinc porphyrin via a coordination bond, with a binding constant K of 1.18 x 10(5) M-1. The photoexcitation of ZnP-Pr-tpy causes the ground state electrons of the tpy moiety to shift to the ZnP unit via an electron-exchange process following the Dexter energy transfer mechanism. Thus, a donor-acceptor composite film, ZnP-Pr-tpy/C-60-py, was fabricated by combining the photosensitizer ZnP-Pr-tpy with C-60-py. A comparison of the over-potential at 10 mA/cm(2), the Tafel slopes and the photocurrent response under visible light irradiation showed the electrocatalytic oxygen evolution reaction (OER) and the photocurrent response to be clearly improved by the covalent modification of the porphyrin with terpyridine, and further improved by the axial coordination of C-60-py to ZnP-Pr-tpy. These improvements are attributed to increased intra- and intermolecular electron transfer, the decrease in the electrochemical impedance resulting from the axial coordination of C-60-py to ZnP-Pr-tpy and the electron-exchange in ZnP-Pr-tpy through the Dexter energy transfer mechanism under light excitation. (C) 2020 Elsevier Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 626-55-1. SDS of cas: 626-55-1.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem