Category: 626-55-1

Reference of 626-55-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 626-55-1, Name is 3-Bromopyridine, SMILES is BrC1=CC=CN=C1, belongs to pyridine-derivatives compound. In a article, author is Zanchin, Giorgia, introduce new discover of the category.

Copolymerization of ethylene with propylene and higher alpha-olefins catalyzed by (imido)vanadium(iv) dichloride complexes

We have synthesized and characterized a series of dimethylamine-imido V(NR)Cl-2(NHMe2)(2) [R = Bu-t (1a), CPh3 (1b), 2,6-CHPh2-4-Cl-C6H2 (1c)], and pyridine-imido V(NR)Cl-2(Py)(3) [R = Bu-t (2a), CPh3 (2b), 2,6-CHPh2-4-Cl-C6H2 (2c)] complexes. The solid-state structures of 1a-1c, and 2c were determined by X-ray crystallography. Complexes 1a and 2a-2c, in combination with Et2AlCl and Cl3CCO2Et, have been screened as catalysts for the copolymerization of ethylene with various alpha-olefins (i.e., propylene, 1-hexene, 1-octene, and 4-methyl-1-pentene). The results are compared with the known PMe2Ph-imido V(NR)Cl-2(PMe2Ph)(2) [R = Bu-t (3a), 2,6-Pr-i(2)-C6H3 (3d)] complexes. Differences in the (co)polymerization regarding the activity and reactivity toward the target comonomers are investigated to probe the effect of imido ligand substitution, and of the coligand. With the exception of dimethylamine 1a, 2 and 3 are instantaneously activated and exhibit good activity, affording copolymers with a moderate comonomer content (4.2 < mol% < 13.7), from low to high molecular weight (36 < M-w x 10(3) g mol(-1) < 270), and unimodal molecular weight distribution (2.1 < M-w/M-n < 2.7), strongly depending on the type of comonomer, copolymerization temperature, and, to a lesser extent, the type of ligand set employed. C-13 NMR spectra of poly(ethylene-co-propylene)s have been fully interpreted as a result of uninterrupted methylene sequence distribution, the ethylene-propylene sequence, and inverted propylene units. In addition, the copolymers were characterized by DSC, TGA, and successive self-nucleation and annealing (SSA). A preliminary investigation of the tensile behavior of the copolymers was performed by uniaxial stretching until failure. Reference of 626-55-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 626-55-1 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 626-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-55-1, name is 3-Bromopyridine, molecular formula is C5H4BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under an N2 atmosphere, a 1.6 M solution of n-butyllithium inhexane (7.06 mL, 11.3 mmol) was added slowly to a cooled(78 C) solution of diisopropylamine (1.25 g, 1.73 mL, 12.4 mmol)in THF (25 mL). After 30-min stirring at 0 C, the mixture wascooled to 78 C and a solution of 3-bromopyridine (5, 1.63 g,1.00 mL, 10.3 mmol) in THF (5 mmol) was added slowly. The mixturewas stirred at 78 C for 15 min, and then a solution ofN-formylpiperidine (5.24 g, 5.14 mL, 46.4 mmol) was addedslowly. The solution was stirred at 78 C for 50 min. Then itwas allowed to warm to room temperature and stirred for another1.5 h. Saturated NH4Cl solution (40 mL) was added. The aqueouslayer was extracted with EtOAc (3 30 mL). The combined organiclayers were washed with brine (60 mL) and dried over Na2SO4.Filtration and evaporation afforded crude product, which waspurified by fc (5.5 cm, EtOAc/cyclohexane 1:4). Yellow solid(EtOAc/cyclohexane2:1, Rf = 0.55), yield 914 mg (48%). 1H NMR(600 MHz, CDCl3): d (ppm) = 7.22 (d, J = 4.9 Hz, 1H, 5-H-Py), 8.72(d, J = 4.9 Hz, 1H, 6-H-Py), 8.92 (s, 1H, 2-H-Py), 10.37 (s, 1H, CHO).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 626-55-1, 3-Bromopyridine.

Reference:
Article; Miyata, Kengo; Moeller, Guido; Schepmann, Dirk; Wuensch, Bernhard; Bioorganic and Medicinal Chemistry; vol. 22; 15; (2014); p. 4277 – 4284;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 626-55-1, 3-Bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 626-55-1, blongs to pyridine-derivatives compound. Recommanded Product: 626-55-1

A mixture of 264 3-bromopyridine (0.38 mL, 4.0 mmol), 265 (4-methoxyphenyl)boronic acid (500 mg, 3.3 mmol), Pd(dppf)Cl2 (69 mg, 0.094 mmol), 105 K2CO3 (720 mg, 5.2 mmol), 31 dioxane (10 mL), and 18 water (5 mL), was bubbled with N2 for 1 min and then stirred at 110 C. for 12 h. After cooling to rt, the mixture was diluted with EtOAc, filtered through Celite, the filtrate washed with water, brine, dried (MgSO4), the solvent was removed by evaporation and the residue was purified (FCC, SiO2, 0-100% EtOAc/heptanes) to provide the 266 title compound (350 mg, 57%) as an off-white solid. 1H NMR (300 MHz, DMSO-d6) delta 8.8 (d, 1H, J=2.1 Hz), 8.5 (q, 1H, J=1.2, 3.3 Hz), 7.85-7.81 (m, 1H), 7.55-7.50 (m, 2H), 7.35-7.26 (m, 1H), 7.04-6.99 (m, 2H), 3.86 (s, 1H). [M+H]=186.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,626-55-1, its application will become more common.

Reference:
Patent; Dart NeuroScience, LLC; Bookser, Brett; Botrous, Iriny; Branstetter, Bryan; Dyck, Brian; Weinhouse, Michael; US2019/177327; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-55-1, name is 3-Bromopyridine, the common compound, a new synthetic route is introduced below. Computed Properties of C5H4BrN

General procedure: In a well-ventilated fume hood, a 15 mL round-bottomed flaskequipped with a Teflon-coated magnetic stirrer bar was chargedwith NiBr2¡¤3H2O (40.9 mg, 0.150 mmol, 0.05 equiv), bathophenanthroline(4; 49.9 mg, 0.150 mmol, 0.05 equiv), DMF (2.0 mL), andalkyl bromide 2 (3.3 mmol, 1.1 equiv). The vessel was stopperedwith a rubber septum and heated to 40 C in a fume hood until agreen homogeneous solution formed (~20 min). The vessel wasthen removed from the heat and 2-halopyridine 1 (3.00 mmol, 1.00equiv) and manganese(0) (-325 mesh; 330 mg, 6.00 mmol, 2.00equiv) were added. The vessel was resealed with the septum, purgedwith argon, and heated again to 40 C while the progress of the reactionwas monitored by GC analysis of aliquots of the crude reactionmixture. In general, the mixtures turned dark brown or blackwhen the reaction was complete. Upon completion of the reaction,the mixture was cooled to r.t., diluted with Et2O (10 mL), and filteredthrough a short pad of Celite 545 (approx. 1 ¡Á 1 ¡Á 1 inch) wettedwith Et2O (~10 mL) to remove metal salts. The Celite pad waswashed with additional Et2O (2 ¡Á 10 mL), and the filtrate was transferredto a separatory funnel and washed with 1 M aq NH4Cl (10mL). The layers were separated and the aqueous layer was washedwith additional Et2O (3 ¡Á 10 mL). The organic extracts were combined,washed with brine (10 mL), dried (MgSO4), filtered, and concentratedunder reduced pressure. The crude products were purifiedby flash column chromatography on silica gel.

The synthetic route of 626-55-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Everson, Daniel A.; Buonomo, Joseph A.; Weix, Daniel J.; Synlett; vol. 25; 2; (2014); p. 233 – 238;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

626-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-55-1, name is 3-Bromopyridine, molecular formula is C5H4BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Methyl 6-bromo-2-phenylpyrazolo[1,5-a]pyridine-3-carboxylate [0424] A 70% perchloric acid aqueous solution (12.9 mL) was added to a 1,4-dioxane solution (31 mL) of ethyl O-mesitylsulfonylacetohydroxamate (35.7 g) under an argon atmosphere under ice-cooling, and then the mixture was stirred for 30 minutes under ice-cooling. Ice water (360 mL) was added to the reaction solution, the precipitated solid was filtered off, the obtained solid was dissolved in dichloromethane (104 mL), and the solution was divided into layers. The organic layer was dried over anhydrous magnesium sulfate and filtered off. A dichloromethane solution (104 mL) of 3-bromopyridine (10 mL) was added to the obtained filtrate under ice-cooling, the mixture was stirred at room temperature for 1 hour, and the reaction solution was evaporated to obtain a crude product N-amino-3-bromopyridinium 2,4,6-trimethylbenzenesulfonate. Methyl phenylpropiolate (7.7 mL) and potassium carbonate (28.7 g) were added to an N,N-dimethylformamide solution (104 mL) of the crude product N-amino-3-bromopyridinium 2,4,6-trimethylbenzenesulfonate at room temperature under an argon atmosphere, and then the mixture was stirred at room temperature for 16 hours. Water was added to the reaction solution and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was evaporated and then the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 4:1) to obtain a title compound as a yellow powder (8.0 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-55-1, 3-Bromopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; Kissei Pharmaceutical Co., Ltd.; SETO, Shigeki; UMEI, Kentaro; NISHIGAYA, Yosuke; TANIOKA, Asao; KONDO, Tatsuhiro; KONDO, Atsushi; TATANI, Kazuya; KAWAMURA, Naohiro; EP2669285; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-55-1, name is 3-Bromopyridine. This compound has unique chemical properties. The synthetic route is as follows. 626-55-1

Synthesis of 3-(4-Methoxyphenyl)pyridine (30) via Scheme 5; A mixture of 3-bromopyridine, (29, 190 mg, 1.20 mmol), 4- methoxyphenylboronic acid (152 mg, 1.00 mmol), Pd(PPh3 )4 (35.0 mg, 0.0300 mmol) and K3PO4 (430 mg, 2.00 mmol) in 1 ,4-dioxane (10 mL) was heated at 100 0C for 18 h. The solvent was removed under reduced pressure and ethyl acetate was added to the solid residue. The organic layer was washed sequentially with water, brine, and then dried over anhydrous Na2SO4. Concentration of the filtrate followed by chromatography [silica, hexanes/ethyl acetate (3: 1 )] gave 30 as a white solid (108 mg, 58% yield), mp 61-63 0C. 1 H NMR (500 MHz, CDCl3) delta 3.86 (s, 3H), 7.01 (d, J = 8.5 Hz, 2H), 7.33 (dd, J = 5.0, 8.0 Hz, 1 H), 7.52 (d, J = 8.5 Hz, 2H), 7.81-7.83 (m, 1 H), 8.54 (dd, J = 2.0, 5.0 Hz, 1 H), 8.81 (br s, 1 H).

Statistics shows that 626-55-1 is playing an increasingly important role. we look forward to future research findings about 3-Bromopyridine.

Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; WO2009/114180; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some common heterocyclic compound, 626-55-1, molecular formula is C5H4BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.626-55-1

Stage 1Methylpyridin-3-ylamine An amount of 100.1 g (633 mmol) of 3-bromopyridine was stirred with 160 ml (1280 mmol) of 8M methylamine in ethanol, 4 g (27.5 mmol) of 8-hydroxyquinoline and 2.2 g (11.5 mmol) of copper(I) iodide in an autoclave at 120 for 16 hours. The mixture was filtered with suction over sand/silica gel and concentrated, aqueous citric acid and cyclohexane were added to the residue, the aqueous phase was saturated with sodium chloride, admixed with dilute aqueous sodium hydroxide solution to a pH of 10 and extracted 6 times with ethyl acetate, and the combined organic phases were dried over MgSO4 and evaporated. The residue was distilled in a bulb tube under a membrane pump vacuum.Yield: 46.8 g (63% of theory), 1H-NMR (CD3CN) 2.75 (s, 3H), 4.3 (br, 1H), 6.85 (m, 1H), 7.05 (m, 1H), 7.8 (m, 1H), 7.95 (m, 1H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 626-55-1.

Reference:
Patent; BAYER CROPSCIENCE AG; US2010/305124; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem