Category: 626-60-8

Reference of 626-60-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-60-8, name is 3-Chloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

A. 3-Chloro-N-(4-chlorophenyl)pyridine-4-carboxamide. A solution of 3-chloropyridine (1.00 mL, 10.5 mmol) in THF at -78 C. was treated dropwise with a solution of lithium diisopropylamide in THF [freshly prepared by addition of butyllithium (7.21 mL, 11.5 mmol) to diisopropylamine (11.5 mmol)]. After 0.25 h, the mixture was treated with carbon dioxide(g) and slowly warmed to ambient temperature. The mixture was concentrated, partitioned between EtOAc and water, and the aqueous layer was washed with EtOAc (2*). The pH of the aqueous layer was adjusted (~3) by addition of 1 N HCl and then washed with EtOAc (3*). The combined extracts were dried with magnesium sulfate and concentrated. The residue was recrystallized from EtOAc yielding 200 mg (12%) of 3-chloroisonicotinic acid.

According to the analysis of related databases, 626-60-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eli Lilly and Company; US6610704; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 626-60-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-60-8, name is 3-Chloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

A. 3-Chloro-N-(4-chlorophenyl)pyridine-4-carboxamide. A solution of 3-chloropyridine (1.00 mL, 10.5 mmol) in THF at -78 C. was treated dropwise with a solution of lithium diisopropylamide in THF [freshly prepared by addition of butyllithium (7.21 mL, 11.5 mmol) to diisopropylamine (11.5 mmol)]. After 0.25 h, the mixture was treated with carbon dioxide(g) and slowly warmed to ambient temperature. The mixture was concentrated, partitioned between EtOAc and water, and the aqueous layer was washed with EtOAc (2*). The pH of the aqueous layer was adjusted (~3) by addition of 1 N HCl and then washed with EtOAc (3*). The combined extracts were dried with magnesium sulfate and concentrated. The residue was recrystallized from EtOAc yielding 200 mg (12%) of 3-chloroisonicotinic acid.

According to the analysis of related databases, 626-60-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eli Lilly and Company; US6610704; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.626-60-8, name is 3-Chloropyridine, molecular formula is C5H4ClN, molecular weight is 113.54, as common compound, the synthetic route is as follows.Application In Synthesis of 3-Chloropyridine

General procedure: Under N2 atmosphere, NHC-Pd(II)-Im 1 (1.0 mol%), dry toluene (2.0 mL), aryl chlorides 2 (0.81 mmol), aryltrimethoxysilanes 3 (2.0 equiv) and TBAF?3H2O (2.0 equiv) were successively added into a Schlenk reaction tube. Then the tube was placed in a 120 C oil bath and stirred for 3 h. The mixture was then allowed to cool to room temperature, diluted with ethyl acetate and washed with brine, dried over anhydrous Na2SO4, concentrated in vacuo and then purified by flash chromatography to give the pure products 4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-60-8, 3-Chloropyridine, and friends who are interested can also refer to it.

Reference:
Article; Gu, Zheng-Song; Shao, Li-Xiong; Lu, Jian-Mei; Journal of Organometallic Chemistry; vol. 700; (2012); p. 132 – 134;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 626-60-8, 3-Chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

General procedure: Biaryls 1; General Procedure for the Suzuki-Miyaura Couplingof Aryl ChloridesA stock solution of Pd source (2 mol%) with ligand (correspondingPd/L ratio) in freshly distilled CH2Cl2 (10 mL) was initially preparedwith continuously stirring at r.t. An array of Schlenk tubesequipped with a Teflon-coated magnetic stirrer bar were evacuatedand backfilled with N2 (3 cycles). The stock solution of Pd with ligand(0.5 mL, 0.1 mol% Pd, or please refer to the corresponding Pdloading from different entries) and Et3N (0.1 mL) were transferredto an array of Schlenk tubes via syringes. The diluted Pd complexsolution was stirred and warmed using a household hair drier forabout 1 to 2 min until the solvent started boiling. The solvent wasthen evaporated under high vacuum. Ar2BF3K (0.75 mmol, 1.5equiv) and base (1.5 mmol, 3.0 equiv) were added to an array ofSchlenk tubes. Each tube was carefully evacuated and backfilledwith N2 (3 cycles). Aryl chloride (0.5 mmol, 1.0 equiv) and H2O(1.5 mL) were added via syringe. This batch of Schlenk tube was resealedand magnetically stirred in a preheated 100 C oil bath. Afterthe completion of the reaction, the reaction tubes were allowed toreach r.t. EtOAc (~10 mL) and H2O (~3 mL) were added. The organiclayer was subjected to GC analysis. The filtrate was concentratedunder reduced pressure. The crude products were purified byflash column chromatography on silica gel (230-400 mesh) to affordthe desired product

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-60-8, 3-Chloropyridine, and friends who are interested can also refer to it.

Reference:
Article; Yuen, On Ying; Wong, Shun Man; Chan, Kin Fai; So, Chau Ming; Kwong, Fuk Yee; Synthesis; vol. 46; 20; (2014); p. 2826 – 2832;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 626-60-8 ,Some common heterocyclic compound, 626-60-8, molecular formula is C5H4ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A. 3-Chloropyridine-1-oxide (775A) Commercially available 3-chloropyridine (11.36 g, 100 mmol) was dissolved in 60 mL of acetic acid and 30% hydrogen peroxide (15 mL) was added. The reaction mixture was heated to 70 C. for 16 h. The cooled reaction mixture was diluted with chloroform and stirred with solid potassium carbonate. The mixture was filtered and solvent removed in vacuo to give compound 775A (10.21 g, 79%) as a yellow-green oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-60-8, 3-Chloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Salvati, Mark E.; Balog, James Aaron; Pickering, Dacia A.; Giese, Soren; Fura, Aberra; Li, Wenying; Patel, Ramesh N.; Hanson, Ronald L.; Mitt, Toomas; Roberge, Jacques Y.; Corte, James R.; Spergel, Steven H.; Rampulla, Richard A.; Misra, Raj N.; Xiao, Hai-Yun; US2004/77605; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 626-60-8, Name is 3-Chloropyridine, molecular formula is C5H4ClN. In an article, author is Mannava, Vennela,once mentioned of 626-60-8, Quality Control of 3-Chloropyridine.

Nickel-Mediated Dehydrogenative Aryl-Aryl Homocoupling of a Bulky Phosphino-Pyridine

Aryl-aryl bond formation through dehydrogenative coupling is an attractive transformation due to the atom and step economy of working with unfunctionalized C-H bonds. Pd catalysts are most common for this process, but Ni complexes have also been targeted as less expensive and more abundant alternatives. Here we report the ability of Ni-0 to activate a sterically encumbered phosphino-pyridine ligand with resulting dehydrogenative aryl-aryl homocoupling. The net H-2 equivalent is transferred to the coligand, resulting in hydrogenation of an olefin unit. We have investigated the mechanism of this process by stirring Ni(1,5-COD)(2) (COD = cyclooctadiene) and the PNPh ligand (PNPh = 2-((di-tert-butylphosphino)methyl)-6-phenylpyridine) at mild temperatures to afford a Ni-II complex. Isolation and characterization shows a PNPh ligand coordinated to Ni-II through an activated pyridine carbon and the directing phosphine. The coligand is an activated allylic cyclooctenyl fragment resulting from partial hydrogenation of 1,5-COD. We propose that this intermediate reacts intermolecularly with 1 equiv of itself, enabling the isolation of a bi-PNPh compound (bi-PNPh = 2,2′-bis((di-tert-butylphosphino)methyl)-6,6′-dipheny1-3,3′-bipyridine), coupled through the activated pyridyl position. This dehydrogenative coupling, although stoichiometric, demonstrates the potential of Ni-0-mediated C(sp(2))-H activation and homocoupling for synthetic applications.

Interested yet? Keep reading other articles of 626-60-8, you can contact me at any time and look forward to more communication. Quality Control of 3-Chloropyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Xu, Songgen, once mentioned the application of 626-60-8, Name is 3-Chloropyridine, molecular formula is C5H4ClN, molecular weight is 113.54, MDL number is MFCD00006375, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Computed Properties of C5H4ClN.

Iron Catalyzed Isomerization of alpha-Alkyl Styrenes to Access Trisubstituted Alkenes

Main observation and conclusion Stereoselective isomerization of alpha-alkyl styrenes is accomplished using a new iron catalyst supported by phosphine-pyridine-oxazoline (PPO) ligand. The protocol provides an atom-efficient and operationally simple approach to trisubstituted alkenes in high yields with excellent regio- and stereoselectivities under mild conditions. The results of deuterium-labelling and radical trap experiments are consistent with an iron-hydride pathway involving reversible alkene insertion and beta-H elimination.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 626-60-8, Computed Properties of C5H4ClN.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 626-60-8, 626-60-8, Name is 3-Chloropyridine, molecular formula is C5H4ClN, belongs to pyridine-derivatives compound. In a document, author is Bastrakov, Maxim A., introduce the new discover.

Reactions of 3-R-5-nitropyridines with nucleophiles: Nucleophilic substitution vs conjugate addition

A number of 3-R-5-nitropyridines were synthesized and their reactions with various types of nucleophiles were investigated. The reaction outcome depends on the nature of a nucleophile: in case of anionic O-, N- and S-nucleophiles the previously unreported substitution of non-activated nitro group occurred while carbon nucleophiles underwent dearomatization of the pyridine ring with the formation of products of 1,2- and 1,4-addition. (C) 2019 Elsevier Ltd. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 626-60-8. SDS of cas: 626-60-8.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Synthetic Route of 626-60-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 626-60-8, Name is 3-Chloropyridine, SMILES is ClC1=CC=CN=C1, belongs to pyridine-derivatives compound. In a article, author is Mohamed, Amira A., introduce new discover of the category.

Mixed-ligand complexes of tenoxicam drug with some transition metal ions in presence of 2,2 ‘-bipyridine: Synthesis, spectroscopic characterization, thermal analysis, density functional theory and in vitro cytotoxic activity

The Preparation and characterization of Cr(III), Fe(III), Co(II), Ni(II), Cu(II) and Y(III) mixed ligand metal complexes with the effective anti-inflammatory drug tenoxicam (Ten) and 2,2’-bipyridine (Bipy) have been informed in this study by using elemental analyses, FT-IR, UV-Vis., H-1 NMR, mass spectra, thermal analyses (TGA, DTG), molar conductance and magnetic moment. FT-IR and UV-Vis. spectra proved that Ten acts as a neutral bidentate ligand chelated to the metal ions via the pyridine-N and oxygen of carbonyl group of the amide moiety and Bipy chelated through the nitrogen atoms. The thermodynamic parameters (E*, Delta S*, Delta H* and Delta G*) were calculated by using Coats-Redfern and Horowitz- Metzger method from DTG curves. The antimicrobial activity for all compounds against various species of bacteria and fungi was investigated and the results ensured that Fe(III) complex is more active than all other complexes. The DFT calculations were carried out to understand the optimized molecular geometry for the compounds. All studied complexes considered as soft respect to the Ten, with G value varied from 11.236 to 16.949 eV and equal to 8.772eV for Ten. The anticancer activity was screened against cell culture of HCT-116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and MCF-7 (human breast adenocarcinoma) for all compounds. (C) 2019 Elsevier B.V. All rights reserved.

Synthetic Route of 626-60-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 626-60-8.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.626-60-8, Name is 3-Chloropyridine, SMILES is ClC1=CC=CN=C1, belongs to pyridine-derivatives compound. In a document, author is Lu, Jianli, introduce the new discover, SDS of cas: 626-60-8.

Constitutive activation of nitrate reductase in tobacco alters flowering time and plant biomass

Pyridine alkaloids produced in tobacco can react with nitrosating agents such as nitrite to form tobacco-specific nitrosamines (TSNA), which are among the most notable toxicants present in tobacco smoke. The market type known as burley tobacco is particularly susceptible to TSNA formation because its corresponding cultivars exhibit a nitrogen-use-deficiency phenotype which results in high accumulation of nitrate, which, in turn, is converted to nitrite by leaf surface microbes. We have previously shown that expression of a constitutively activated nitrate reductase (NR) enzyme dramatically decreases leaf nitrate levels in burley tobacco, resulting in substantial TSNA reductions without altering the alkaloid profile. Here, we show that plants expressing a constitutively active NR construct, designated 35S:S523D-NR, display an early-flowering phenotype that is also associated with a substantial reduction in plant biomass. We hypothesized that crossing 35S:S523D-NR tobaccos with burley cultivars that flower later than normal would help mitigate the undesirable early-flowering/reduced-biomass traits while maintaining the desirable low-nitrate/TSNA phenotype. To test this, 35S:S523D-NR plants were crossed with two late-flowering cultivars, NC 775 and NC 645WZ. In both cases, the plant biomass at harvest was restored to levels similar to those in the original cultivar used for transformation while the low-nitrate/TSNA trait was maintained. Interestingly, the mechanism by which yield was restored differed markedly between the two crosses. Biomass restoration in F-1 hybrids using NC 645WZ as a parent was associated with delayed flowering, as originally hypothesized. Unexpectedly, however, crosses with NC 775 displayed enhanced biomass despite maintaining the early-flowering trait of the 35S:S523D-NR parent.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 626-60-8 is helpful to your research. SDS of cas: 626-60-8.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem