Category: 626-64-2

Discovery of NLO Semiorganic (C₅H₆ON)⁺(H₂PO₄)^–: Dipole Moment Modulation and Superior Synergy in Solar-Blind UV Region was written by Lu, Jing;Liu, Xin;Zhao, Min;Deng, Xue-Bin;Shi, Ke-Xin;Wu, Qian-Ru;Chen, Ling;Wu, Li-Ming. And the article was included in Journal of the American Chemical Society in 2021.Quality Control of Pyridin-4-ol This article mentions the following:

We herein report a novel semiorg. NLO material, (C₅H₆ON)⁺(H₂PO₄)^–, 4HPP, showing promising excellent properties in the important solar-blind UV region where LAP and its deuterated form DLAP are the only commercialized semiorg. materials. For the first time, the 4-hydroxypyridine (4HP⁺, (C₅H₆ON)⁺) cation is identified as NLO active and how to eliminate the dipole-dipole interaction to avoid the unwanted center-symmetry-trap caused by the polar-induced susceptibility is well demonstrated. Remarkably, 4HPP exhibits competitive and even better properties compared with LAP that include better thermal stability (decomposition at 166 vs 112鎺矯 of LAP); wider transparency range (0.26-1.50娓璵); very strong SHG response (3 x KDP); a suitable large birefringence (铻杗_cal = 0.25 vs 0.075 of LAP); and a high laser-induced damage threshold (2.2 x KDP). First-principles calculations show that the 锜?conjugated organic (4HP)⁺ cation governs the optical anisotropy, whereas the synergy of the organic and inorganic moieties dominates the SHG process. Our discovery points out a new path for the rational design of high performance semiorg. materials that require an acentric structure. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cyclometalated iridium-coumarin ratiometric oxygen sensors: improved signal resolution and tunable dynamic ranges was written by Wu, Yanyu;Sutton, Gregory D.;Halamicek, Michael D. S.;Xing, Xinxin;Bao, Jiming;Teets, Thomas S.. And the article was included in Chemical Science in 2022.Product Details of 626-64-2 This article mentions the following:

In this work we introduce a new series of ratiometric oxygen sensors based on phosphorescent cyclometalated iridium centers partnered with organic coumarin fluorophores. Three different cyclometalating ligands and two different pyridyl-containing coumarin types were used to prepare six target complexes with tunable excited-state energies. Three of the complexes display dual emission, with fluorescence arising from the coumarin ligand, and phosphorescence from either the cyclometalated iridium center or the coumarin. These dual-emitting complexes function as ratiometric oxygen sensors, with the phosphorescence quenched under O₂ while fluorescence is unaffected. The use of blue-fluorescent coumarins results in good signal resolution between fluorescence and phosphorescence. Moreover, the sensitivity and dynamic range, measured with Stern-Volmer anal., can be tuned two orders of magnitude by virtue of our ability to synthetically control the triplet excited-state ordering. The complex with cyclometalated iridium 3MLCT phosphorescence operates under hyperoxic conditions, whereas the two complexes with coumarin-centered phosphorescence are sensitive to very low levels of O₂ and function as hypoxic sensors. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis was written by Malwal, Satish R.;Chen, Lu;Hicks, Hunter;Qu, Fiona;Liu, Weidong;Shillo, Alli;Law, Wen Xuan;Zhang, Jianan;Chandnani, Neal;Han, Xu;Zheng, Yingying;Chen, Chun-Chi;Guo, Rey-Ting;Abdel Khalek, Ahmed;Seleem, Mohamed N.;Oldfield, Eric. And the article was included in Journal of Medicinal Chemistry in 2019.Formula: C5H5NO This article mentions the following:

We report that alkyl-substituted bisphosphonates have activity against Bacillus anthracis Sterne (0.40娓璯/mL), Mycobacterium smegmatis (1.4娓璯/mL), Bacillus subtilis (1.0娓璯/mL), and Staphylococcus aureus (13娓璯/mL). In many cases, there is no effect of serum binding, as well as low activity against a human embryonic kidney cell line. Targeting of isoprenoid biosynthesis is involved with 74 having IC₅₀ values of 閳?00 nM against heptaprenyl diphosphate synthase and 200 nM against farnesyl diphosphate synthase. B. subtilis growth inhibition was rescued by addition of farnesyl diphosphate, menaquinone-4 (MK-4), or undecaprenyl phosphate (UP), and the combination of MK-4 and UP resulted in a 25鑴?increase in ED₅₀, indicating targeting of both quinone and cell wall biosynthesis. Clostridioides difficile was inhibited by I, and since this organism does not synthesize quinones, cell wall biosynthesis is the likely target. We also solved 3 X-ray structures of inhibitors bound to octaprenyl diphosphate and(or) undecaprenyl diphosphate synthases. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, spectral, structural characterization and Hirshfeld surface analysis of bis(4-hydroxypyridinium) hexacholorostannate(IV) hybrid was written by Vijayasri, M.;Parthiban, S.. And the article was included in Molecular Crystals and Liquid Crystals.Formula: C5H5NO This article mentions the following:

Single-crystal XRD studies of Bis(4-hydroxypyridinium) hexacholorostannate(IV) reveals that the crystal belongs to a triclinic system with Pi space group. The X-ray crystallog. structure has [C₅H₆ON]⁺ 0.5[SnCl₆]^2- asym. unit. The band gap value for the hybrid is 3.92 eV estimated using the Kubelka-Munk function. The Bond valence sum (BVS) of tin was calculated as 3.95 based on the Sn-Cl bond distances, which is close to its formal oxidation state of +4. Exploration of the intermol. interactions and the crystal packing using Hirshfeld surface anal., derived from single-crystal XRD data, reveals the close contacts associated with strong interactions. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Direct Synthesis of N-Difluoromethyl-2-pyridones from Pyridines was written by Zhou, Sen;Hou, Xiaoya;Yang, Kai;Guo, Minjie;Zhao, Wentao;Tang, Xiangyang;Wang, Guangwei. And the article was included in Journal of Organic Chemistry in 2021.HPLC of Formula: 626-64-2 This article mentions the following:

A novel method for the synthesis of N-difluoromethyl-2-pyridones was described. This protocol enables the synthesis of N-difluoromethyl-2-pyridones from readily available pyridines using mild reaction conditions that are compatible with a wide range of functional groups. The preliminary mechanistic study revealed that N-difluoromethylpyridinium salts were the key intermediates to complete this conversion. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2HPLC of Formula: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.HPLC of Formula: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metalation Studies of Carbophosphazene-Based Coordination Ligands: Metallacages to Polymeric Networks was written by Senapati, Tapas;Dey, Atanu;Kumar, Vierandra;Chandrasekhar, Vadapalli. And the article was included in Crystal Growth & Design in 2020.Safety of Pyridin-4-ol This article mentions the following:

The metalation behavior of [NC(NMe₂)]₂[NP(p-OC₅H₄N)₂] (L1) and [NC(NMe₂)]₂[NP(m-OC₅H₄N)₂] (L2) is described. The ligands L1 and L2 were prepared by the reaction of the carbophosphazene, [NC(NMe₂)]₂[NPCl₂] with 4-hydroxy pyridine or 3-hydroxy pyridine. The disposition of the coordinating nitrogen atoms does not allow the coordinating groups within the same mol. to bind to a single metal ion. This leads to the formation of mol. complexes (di- and tetranuclear) and coordination polymers (one- and two-dimensional). Thus, the interaction of L1 with a Hg(II) salt afforded a dinuclear complex, [Hg(Cl)₂(L1)]₂ (1). The reaction of L2 with Ag(I) salts afforded both dinuclear complexes and tetranuclear complexes, [Ag(CF₃SO₃)(L2)]₂ (2) and [Ag(NO₃)(L2)]₄璺?MeOH (3), resp. The reaction of copper acetate with L1 or L2 afforded one-dimensional polymeric networks [Cu₂(CH₃COO)₄(L1)]_n (4) and [Cu₂(CH₃COO)₄(L2)]_n (5). In 4 and 5, the basic dinuclear motif of copper acetate is preserved. In contrast to the reaction of L1 with HgCl₂ which afforded a dinuclear complex 1, a similar reaction with L2 resulted in a two-dimensional polymeric network, [Hg(Cl)₂(L2)]_n (6). Similarly, the interaction of L2 with CoCl₂ afforded a two-dimensional coordination polymer, [Co(Cl)₂(L2)₂]_n (7). The latter contains 40-membered metallacylces, which are fused to each other in the formation of the coordination polymer. The efficacy of the carbophosphazene based ligands [NC(NMe₂)]₂[NP(p-OC₅H₄N)₂] (L1) and [NC(NMe₂)]₂[NP(m-OC₅H₄N)₂] (L2) toward metalation is described. The different disposition of the coordinating groups (meta vs para) in the carbophosphazene based platform impacts a pivotal role toward metalation, resulting m mol. complexes to coordination polymers. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electronic substituent effect on Se-H璺矾璺疦 hydrogen bond: A computational study of para-substituted pyridine-SeH₂ complexes was written by Jaju, Karan;Pal, Dhritabrata;Chakraborty, Amrita;Chakraborty, Shamik. And the article was included in Chemical Physics Letters: X in 2019.Safety of Pyridin-4-ol This article mentions the following:

Complexes between para-substituted pyridine and SeH₂ have been investigated at the MP2/aug-cc-pVTZ level. Various electron donating and withdrawing substituents (-NH₂, -OH, -CH₃, -H, -F, -Cl, -CN, and -NO₂) are chosen in order to characterize their influence on Se-H璺矾璺疦 intermol. hydrogen-bonding interaction. The electron donating substituents lead to an increase of the stabilization energy along with elongation in the Se-H bond length and red-shift in Se-H stretching frequency. Conventional electronic substitution effect has been observed on various hydrogen-bond parameters, such as, stabilization energy, change in Se-H bond length and stretching frequency, charge transfer, bond order, electron d. at hydrogen-bond critical point. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, structural characterization and Hirshfeld surface analysis of NLO active 3-hydroxypyridinium 2,4-dinitrophenolate single crystals was written by Manikandan, A.;Manivannan, D.;Dhanalakshmi, M.;Guganathan, L.;Kokila, T.;Santhamoorthy, M.;Markkandan, R.;Kim, S. C.;Balakrishnan, C.. And the article was included in Journal of Materials Science: Materials in Electronics in 2022.Safety of Pyridin-4-ol This article mentions the following:

Single crystals of 3-hydroxypyridinium 2,4-dinitrophenolate (I) and 4-hydroxypyridinium 2,4-dinitrophenolate (II) was harvested under slow evaporation conditions. The yellow block crystals formed by O-H璺矾璺疧 and N-H璺矾璺疧 hydrogen bonding that made contacts through the cation and anion was characterized by single-crystal X-ray diffraction, IR spectrum, diffuse reflectance spectrum, thermogravimetric and Hirshfeld surface anal. Crystal (I) packed orthorhombic crystal system with acentric P212121 space group and (II) packed in monoclinic system with centric P21/c space group. Intra-/intermol. hydrogen bonds and weak van der Waals forces construct the supramol. network in the crystal packing. The bandgap energy was estimated using diffuse reflectance spectral data by the application of the Kubelka-Munk algorithm. The non-linear optical response is examined by the Kurtz-Perry technique gave the result that the efficacy of crystal (I) is 閳?4 times greater than that of reference KDP. TG/DTA anal. reveals the thermal pattern of the compounds Fingerprint plot used to locate and analyze the percentage contribution of hydrogen bonding interactions. First-order mol. hyperpolarizability calculated using theor. calculations shows a significant microlevel nonlinearity in both cases. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aryl H-phosphonates. 19. New anti-HIV pro-nucleotide phosphoramidate diesters containing amino- and hydroxypyridine auxiliaries was written by Romanowska, Joanna;Kolodziej, Krystian;Sobkowski, Michal;Rachwalak, Marta;Jakubowski, Tomasz;Golebiewska, Justyna;Kraszewski, Adam;Boryski, Jerzy;Dabrowska, Aleksandra;Stawinski, Jacek. And the article was included in European Journal of Medicinal Chemistry in 2019.Application of 626-64-2 This article mentions the following:

We have designed a new type of AZT and ddU phosphoramidate diesters containing various combinations of 2-, 3-, 4-aminopyridine and 2-, 3-, 4-hydroxypyridine moieties attached to the phosphorus center, as potential anti-HIV pro-nucleotides. Depending on the pK_a values of the aminopyridines and the hydroxypyridines used, alternative synthetic strategies based on H-phosphonate chem. were developed for their preparation Synthetic aspects of these transformations and the biol. activity of the synthesized compounds are discussed. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Host-guest interaction-directed strategy for managing mechanochromic luminescence behavior by modulating molecular packing and conformation was written by Han, Xie;Sun, DongDong;Tang, Shi;Wu, Yong;Wang, Luyao;Zhang, Xiongzhi;Liu, Simin. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2021.SDS of cas: 626-64-2 This article mentions the following:

Developing a simple strategy to precisely modulate the mechanochromic luminescence (MCL) behavior of fluorophores is of great significance in understanding their structure-property relationship and promoting their potential application. Herein, we report a donor-acceptor (D-A) mol. 1-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)pyridin-4-one (NBDP), which shows a bathochromic shift of fluorescence upon grinding. Interestingly, when NBDP is absorbed by cucurbit[8]uril (CB[8]) solid, the formed NBDP@CB[8] complex exhibits an unexpected hypsochromic shift. Detailed spectroscopic and structural analyses suggest that mol. packing and conformation change induced by host-guest interactions are responsible for the distinct luminescence response. This strategy is both conceptually and synthetically simple and offers a promising approach for the construction of new MCL systems. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2SDS of cas: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem