Category: 626-64-2

Metabolomic investigation of ultraviolet ray-inactivated white spot syndrome virus-induced trained immunity in Marsupenaeus japonicus was written by Zang, Shaoqing;Lv, Li-Xia;Liu, Chen-Fei;Zhang, Peng;Li, Cang;Wang, Jin-Xing. And the article was included in Frontiers in Immunology in 2022.Formula: C5H5NO This article mentions the following:

Trained immunity is driven by metabolism and epigenetics in innate immune cells in mammals. The phenomenon of trained immunity has been identified in invertebrates, including shrimp, but the underlying mechanisms remain unclear. To elucidate mechanisms of trained immunity in shrimp, the metabolomic changes in hemolymph of Marsupenaeus japonicus trained by the UV-inactivated white spot syndrome virus (UVWSSV) were analyzed using tandem gas chromatog.-mass/mass spectrometry. The metabolomic profiles of shrimp trained with UV-WSSV followed WSSV infection showed significant differences comparison with the control groups, PBS injection followed WSSV infection. 16 differential metabolites in total of 154 metabolites were identified, including Dfructose-6-phosphate, D-glucose-6-phosphate, and D-fructose-6-phosphate, and metabolic pathways, glycolysis, pentose phosphate pathway, and AMPK signaling pathway were enriched in the UV-WSSV trained groups. Further study found that histone monomethylation and trimethylation at H3K4 (H3K4me1 and H3K4me3) were involved in the trained immunity. Our data suggest that the UV-WSSV induced trained immunity leads to metabolism reprogramming in the shrimp and provide insights for WSSV control in shrimp aquaculture. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Light-promoted synthesis of surface-grafted polymers bearing pyridine groups by metal-free ATRP in microliter volumes was written by Slowikowska, Monika;Wojcik, Artur J.;Wolski, Karol;Hatalak, Anna;Zapotoczny, Szczepan. And the article was included in Polymer in 2021.Synthetic Route of C5H5NO This article mentions the following:

Polymers with pendant pyridine groups (PPPGs) are pH responsive weak polyelectrolytes potentially attractive for many applications such as sensors, antibacterial coatings, and ion gating systems. Synthesis of PPPGs by classical atom transfer radical polymerization (ATRP) is challenging due to highly probable formation of monomer/metal complexes. In response to that, we report here a facile synthetic strategy to obtain surface-grafted PPPGs that utilizes light-mediated ATRP. Metal-free surface-initiated ATRP catalyzed by 10-phenylphenothiazine is used to polymerize three isomeric monomers with methacrylate groups attached at various positions of a pyridine ring. The reactivity of the isomers is compared for selection of optimal monomer structure leading to thick brushes. The polymerizations are conducted under visible light, at ambient conditions, and using only microliter volumes of the reaction mixture that is important for reducing the complexity and costs of the process and limiting chem. waste. The observed linear dependency of the brush thickness vs. polymerization time for poly(pyridin-3-yl methacrylate) (PP3M) grafted from indium tin oxide or silicon wafers indicated the controlled characteristics of the developed method. The obtained PP3M brush demonstrated pH responsive behavior associated with protonation of pyridine groups in acidic solution and adoption of highly stretched conformation below pK_a. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Synthetic Route of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The roles of metabolic pathways in maintaining primary dormancy of Pinus koraiensis seeds was written by Song, Yuan;Zhu, Jiaojun. And the article was included in BMC Plant Biology in 2019.Quality Control of Pyridin-4-ol This article mentions the following:

Background: Korean pine seeds have primary dormancy following dispersal, leading to poor seed germination and seedling establishment. Metabolic homeostasis determines whether the seeds are dormant or non-dormant. However, the specific metabolic pathways that maintain the primary dormancy of pine seeds are poorly understood. Results: Metabolic anal. was employed on the embryos of PDRS (seeds released from primary dormancy) and PDS (primary dormant seeds) on days 0, 5 and 11 after incubation under a germination-inductive temperature A larger metabolic switch occurred in PDRS embryos from days 0 to 11. The contents of ninety metabolites were significantly changed from days 0 to 5, 83% of which (including most sugars, organic acids and amino acids) increased, reflecting that biosynthetic metabolism processes are initiated. The contents of ninety-two metabolites showed distinct variations from days 5 to 11, 71% of which (including most organic acids and almost all amino acids) reduced substantially. Fructose 6-phosphate, inositol-3-phosphate, 3-phosphoglyceric and D-glucose-6-phosphate contents showed the most decrease with decreasing 409-, 75-, 58- and 41-fold, indicating that the glycolysis and tricarboxylic acid (TCA) cycle strongly slowed down. The contents of the most metabolites in PDS embryos also displayed a relatively larger alteration only from days 0 to 5. Although 64% of metabolites increased from days 0 to 5, their levels were still lower compared with PDRS embryos. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A Predictive Strategy Based on Volatile Profile and Chemometric Analysis for Traceability and Authenticity of Sugarcane Honey on the Global Market was written by Silva, Pedro;Freitas, Jorge;Nunes, Fernando M.;Camara, Jose S.. And the article was included in Foods in 2021.Electric Literature of C5H5NO This article mentions the following:

Sugarcane honey (SCH) is a syrup produced on Madeira Island and recognized by its unique aroma, a complex attribute of quality with an important influence on the final consumer’s acceptance of the product, and determined by a complex mixture of a large number of volatile organic compounds (VOCs) generated during its traditional making process and storage. Therefore, the purpose of this study was to establish the volatile profile of genuine SCH produced by a regional certified producer for seven years and compare it with syrups from non-certified regional producers and with producers from different geog. regions (Spain, Egypt, Brazil and Australia), as a powerful strategy to define the volat. fingerprint of SCH. Different volatile profiles were recognized for all samples, with 166 VOCs being identified belonging to different chem. classes, including furans, ketones, carboxylic acids, aldehydes and alcs. Chemometric anal. allowed (i) the differentiation between all syrups, being more pronounced between SCH and other syrups; and (ii) the identification of 32 VOCs as potential markers for the traceability and authenticity of SCH on the global market. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metalloporphyrin as a Biomimetic Catalyst for the Catalytic Oxidative Degradation of Lignin to Produce Aromatic Monomers was written by Xie, Jinfeng;Ma, Guanfeng;Ouyang, Xinping;Zhao, Lisha;Qiu, Xueqing. And the article was included in Waste and Biomass Valorization in 2020.Electric Literature of C5H5NO This article mentions the following:

Lignin, an abundant biomass waste, was degraded under microwave irradiation with H₂O₂ as the oxidant and metalloporphyrin as the catalyst. The effect of substituent group (4-methylphenyl, 4-methoxyphenyl, 4-bromophenyl and 4-carboxyphenyl) at the meso-benzene ring of metalloporphyrin, central metal ion (Co, Mn, Ni and Fe) and axial ligand (chlorine, p-hydroxypyridine, p-pyridinecarboxaldehyde) on the degradation of lignin was investigated. The electron-withdrawing group not only reduces the electron cloud d. on the porphyrin ring, but also promotes the formation of higher active intermediate [(Porp)MeIV=O]^+·. Therefore, the presence of stronger electron-withdrawing substituents makes the metalloporphyrins more efficient in lignin degradation Compared to Co porphyrin, there are less amount of [(Porp)MeIV=O]^+· formed when Mn, Fe or Ni porphyrin was used as the catalyst for degrading lignin. Consequently, Co porphyrin contributed to a higher YAM (the yield of aromatic monomers). The strong nucleophilicity and the low steric hindrance of axial ligand was advantageous for the stability of metalloporphyrins, which is favorable for improving the catalytic activity to the degradation of lignin. It is found that the YAM increases 20.1% from 5.6% by using CoTBrPPCl as the reaction catalyst under the optimized conditions. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metalloporphyrin as a Biomimetic Catalyst for the Catalytic Oxidative Degradation of Lignin to Produce Aromatic Monomers was written by Xie, Jinfeng;Ma, Guanfeng;Ouyang, Xinping;Zhao, Lisha;Qiu, Xueqing. And the article was included in Waste and Biomass Valorization in 2020.Electric Literature of C5H5NO This article mentions the following:

Lignin, an abundant biomass waste, was degraded under microwave irradiation with H₂O₂ as the oxidant and metalloporphyrin as the catalyst. The effect of substituent group (4-methylphenyl, 4-methoxyphenyl, 4-bromophenyl and 4-carboxyphenyl) at the meso-benzene ring of metalloporphyrin, central metal ion (Co, Mn, Ni and Fe) and axial ligand (chlorine, p-hydroxypyridine, p-pyridinecarboxaldehyde) on the degradation of lignin was investigated. The electron-withdrawing group not only reduces the electron cloud d. on the porphyrin ring, but also promotes the formation of higher active intermediate [(Porp)MeIV=O]^+·. Therefore, the presence of stronger electron-withdrawing substituents makes the metalloporphyrins more efficient in lignin degradation Compared to Co porphyrin, there are less amount of [(Porp)MeIV=O]^+· formed when Mn, Fe or Ni porphyrin was used as the catalyst for degrading lignin. Consequently, Co porphyrin contributed to a higher YAM (the yield of aromatic monomers). The strong nucleophilicity and the low steric hindrance of axial ligand was advantageous for the stability of metalloporphyrins, which is favorable for improving the catalytic activity to the degradation of lignin. It is found that the YAM increases 20.1% from 5.6% by using CoTBrPPCl as the reaction catalyst under the optimized conditions. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem