Category: 626-64-2

A common compound: 626-64-2, name is Pyridin-4-ol,molecular formula is C5H5NO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 626-64-2

In a 500 ml round bottom flask were mixed pyridin-4-ol (5 g, 52.6mmol), dry THF (200 ml), tert- butyl 4-hydroxypiperidine-1 -carboxylate (13.3 g, 65.8mmol) and PPh3 (18 g, 68.4 mmol). Then DEAD (12 g, 68.4 mmol) was added dropwise at RT. The RM was stirred at RT for 3 h, then the RM was concentrated. Purification by chromatography on silica gel eluting with 3% MeOH in DCM afforded 10 g of the title compound as a white solid. LC-MS (method H): Rt = 1 .35 min, [M+H]+ = 279.3

With the rapid development of chemical substances, we look forward to future research findings about 626-64-2.

Reference:
Patent; NOVARTIS AG; ARISTA, Luca; HEBACH, Christina; HOLLINGWORTH, Gregory John; HOLZER, Philipp; IMBACH-WEESE, Patricia; MACHAUER, Rainer; SCHMIEDEBERG, Niko; VULPETTI, Anna; ZOLLER, Thomas; (145 pag.)WO2019/186358; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 626-64-2, Pyridin-4-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 626-64-2, blongs to pyridine-derivatives compound. 626-64-2

To a mixture of 4-hydroxypyridine (0.953 g, 10 mmol) and DBU (2.3 mL, 15 mmol, 1.5 equiv) in DMF (20 mL) was added p-methoxybenzyl chloride (2.0 mL, 15 mmol, 1.5 equiv). The reaction mixture was stirred at 66 C for 4 h. After cooling to the room temperature, the solvent was removed under reduced pressure. The residue was partitioned between CHCl3 and H2O. The organic layer was washed with saturated aqueous NaCl solution, dried over anhydrous MgSO4, and then concentrated under reduced pressure. The residue was purified by flash column chromatography (CHCl3/MeOH=9:1, Rf=0.30) to give the white solid (11, 1.89 g, 8.8 mmol, 88%). Mp 166-168 C (from column); 1H NMR (CDCl3, 400 MHz) delta 7.35 (d, 2H, J=7.6 Hz, CH), 7.12 (d, 2H, J=8.8 Hz, CH), 6.88 (d, 2H, J=8.8 Hz, CH), 6.31 (d, 2H, J=7.6 Hz, CH), 4.87 (s, 2H, CH2), 3.77 (s, 3H, CH3); 13C NMR (CDCl3, 100 MHz) delta 178.8, 159.9, 139.9 (CH), 129.1 (CH), 126.7, 118.5 (CH), 114.5 (CH), 59.5 (CH2), 55.3 (CH3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,626-64-2, its application will become more common.

Reference:
Article; Cheng, Chien; Shih, Yu-Chiao; Chen, Hui-Ting; Chien, Tun-Cheng; Tetrahedron; vol. 69; 4; (2013); p. 1387 – 1396;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-64-2, name is Pyridin-4-ol, the common compound, a new synthetic route is introduced below. 626-64-2

Al.l 4-Etaydroxypyridine ( 40.Og, 0.42 mol ) was added portionwise to fuming nitric acid (140 ml) and sulfuric acid (500ml). The resulting mixture was heated to 1400C for 12 hours. The reaction mixture was cooled in an ice-bath and cautiously poured onto ice (500ml). The yellow solid which precipitated was collected by filtration and dried under vacuum to yield Al.l ( 70.Og, 90%). 1H-NMR ( DMSO-d6) 6: 4.06 ( 2H, s). HPLC (B): 98.9%, ret. time = 0.173 min., LC/MS (M-H)+ = 184.

Statistics shows that 626-64-2 is playing an increasingly important role. we look forward to future research findings about Pyridin-4-ol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2006/53166; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

626-64-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-64-2, name is Pyridin-4-ol, the common compound, a new synthetic route is introduced below.

To a solution of tert-butyl 3-hydroxyazetidine-1-carboxylate 1 (4.55 g, 26.3 mmol) inTHF (100 mL) was added pyridin-4-ol (2.0 g, 21.0 mmol), PPh3 (6.89 g, 26.3 mmol)and DEAD (4.57 g, 26.3 mmol). The resulting reaction mixture was stirred at 70 Covernight. TLC indicated that the reaction was complete. The reaction mixture wasconcentrated in vacuum. The resulting oil was dissolved in 1 .0 M aqueous HCI solution C 20 mL) and extracted with DCM (50 mL x 3), The combined organic phases were washed with HCI (aq) solution (0.5 M, 150 mL). The aqueous fractions were combined and basified to pH12 using NaOH (1.0 M) and extracted with DCM(100 mL x 3) . The combined organic phases were dried over anhydrous Na2SO4,filtered and concentrated in vacuum. The residue was purified by column chromatography on silica gel to afford to afford 4 (2.81 91 53% yield) as a solid.1HNMR (400 MHz, DMSO-d6): 5 8.41 (d, J 6.0 Hz, 2 H), 6.88 (d, J = 6.0 Hz, 2 H),5.07-5.09 (m, 1 H), 4.32-4.33 (m, 2 H), 3.80-3.82 (m, 2 H)3 1.39 (s, 9 H). MS Calcd.:250; MS Found: 251 ([M+Hfl.

Statistics shows that 626-64-2 is playing an increasingly important role. we look forward to future research findings about Pyridin-4-ol.

Reference:
Patent; H. LUNDBECK A/S; SVENSTRUP, Niels; WEN, Kate; WANG, Yazhou; (78 pag.)WO2017/5786; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

626-64-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-64-2, name is Pyridin-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

9.5 g (0.10 mol) of 4-hydroxypyridine,, 21.5 g (0.11 mol) of 4-bromobutyric acid ethyl ester,0.5 g of 5% Pd / C catalyst,80 ml of ethanol was placed in a 300 ml autoclave, and the interior of the container was replaced with hydrogen.While introducing hydrogen gas into the vessel, the reactor was heated to 100 C. while stirring, and the reaction was carried out at a hydrogen pressure of 4.9 ¡Á 10 5 Pa for 9 hours.After allowing the reactor to cool down, disappearance of 4-hydroxypyridine was confirmed by TLC. The catalyst was removed by filtration, and the obtained reaction solution was concentrated.To the residue was added 100 ml of water and extracted with 60 ml of ethyl acetate, and the organic layer was dried and concentrated. After drying the obtained solid under reduced pressure, 18.3 g (85 mmol, yield 85%) of (4-hydroxy) -4-piperidinobutanoic acid ethyl ester was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 626-64-2, Pyridin-4-ol.

Reference:
Patent; TOKUYAMA CORPORATION; SEKI, MASAHIKO; YAMAMOTO, HIROMASA; (13 pag.)JP2018/24593; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

626-64-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-64-2, name is Pyridin-4-ol, molecular formula is C5H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a mixture of chlorinated derivatives of dihydropyrimidinonederivatives 4a-i (1 equiv.), potassium carbonate (2.5 equiv.) in acetonitrile,under 80 C was added different aryl/ heteroaryl alcohols(5a-k, 0.75 equiv.) and stirred under reflux till complete consumptionof the starting materials as determined by TLC. The solvent was thenremoved using rotary evaporator and extracted using ethyl acetate(25 mL¡Á3) and water. The organic layer was concentrated under invacuo and the residue obtained was chromatographed on silica gel(elution with hexane/EtOAc=7:3-5:5) to provide the 2-oxo-6-(aryloxymethyl)-4-aryl/heteroaryl-1,2,3,4-tetrahydropyrimidine-5-carboxylatederivatives 6a-s in moderate to good yields.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-64-2, Pyridin-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sana, Sravani; Tokala, Ramya; Bajaj, Deepti Madanlal; Nagesh, Narayana; Bokara, Kiran Kumar; Kiranmai, Gaddam; Lakshmi, Uppu Jaya; Vadlamani, Swapna; Talla, Venu; Shankaraiah, Nagula; Bioorganic Chemistry; vol. 93; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem