Category: 6265-73-2

Related Products of 6265-73-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6265-73-2, name is N-(2-Hydroxyethyl)nicotinamide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The nitrated compounds were obtained by mixing fuming nitric acid (10 mmol) and the hydroxylated precursors (1 mmol) at -5.0 C and stirring for 2h. The reaction mixture was poured into a mixture of water and ice. The pH was adjusted to 6.0 by adding CaCO3. The obtained solid was vacuum filtered and recrystallized in ethanol, which furnished a white solid in all cases.

According to the analysis of related databases, 6265-73-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cesar, Isabela C.; Godin, Adriana M.; Araujo, Debora P.; Oliveira, Francinely C.; Menezes, Raquel R.; Santos, Julliana R.A.; Almeida, Mariana O.; Dutra, Marcela M.G.B.; Santos, Daniel A.; MacHado, Renes R.; Pianetti, Gerson A.; Coelho, Marcio M.; De Fatima, Angelo; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2783 – 2790;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6265-73-2, name is N-(2-Hydroxyethyl)nicotinamide. A new synthetic method of this compound is introduced below., HPLC of Formula: C8H10N2O2

Example 42 A mixture of 10-(2,3-dimethylpentanoylamino)-7-methyl-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic acid (250 mg) and thionyl chloride (4 ml) was stirred at 10C for 30 minutes. The reaction mixture was stirred for 1 hour at room temperature, and then evaporated to dryness in vacuo to give an acid chloride. A mixture of the acid chloride, pyridine (0.1 ml) and dry dichloromethane (60 ml) was cooled to 5C. A solution of N-(2-hydroxyethyl)nicotinamide (108 mg) in dry dichloromethane was added to the mixture. The reaction mixture was stirred at 5C for 1 hour, and allowed to stand at room temperature overnight. The reaction mixture was diluted with chloroform-methanol, and washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was subjected to a column chromatography on silica gel with chloroform-methanol. The elude was concentrated in vacuo to give residue, which was recrystallized from chloroform-ether to give 2-(nicotinamido)ethyl 7-methyl-10-(2,3-dimethylpentanoylamino)-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (0.26 g). mp: 204-210C IR (Nujol): 3250, 1730, 1650, 1630, 1226, 1120, 1060, 800 cm-1 NMR (DMSO-d6, delta): 0.5-2.0 (13H, m), 3.27 (3H, s), 3.70 (2H, m), 4.42 (2H, m), 7.3-9.4 (10H, m), 10.32 (1H, s)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6265-73-2, N-(2-Hydroxyethyl)nicotinamide.

Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; EP143001; (1991); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6265-73-2, name is N-(2-Hydroxyethyl)nicotinamide. A new synthetic method of this compound is introduced below., Safety of N-(2-Hydroxyethyl)nicotinamide

General procedure: A4 (100mg, 0.6mmol) was combined with 2-chloro-4-nitrophenyl isothiocyanate (129mg, 0.6mmol) in anhydrous THF (30mL) at 0C, followed by the addition of DBU (106mg, 0.7mmol). The resultant mixture was stirred at 0C for 20min, after which the ice bath was removed, and the reaction mixture was stirred at room temperature until the completion of the reaction indicated by TLC. The crude product was purified by column chromatography (chloroform/methanol, 30/1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6265-73-2, N-(2-Hydroxyethyl)nicotinamide.

Reference:
Article; Bai, Zhongjie; Zhang, Jinlong; Zhang, Qiuping; Wang; Li, Jili; Zhao, Quanyi; Wang, Zhen; He, Dian; Zhang, Jingke; Liu, Bin; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3307 – 3318;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem