62674-71-9 | Pyridine-derivatives

New learning discoveries about 62674-71-9

With the rapid development of chemical substances, we look forward to future research findings about 62674-71-9.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62674-71-9, name is 2-Iodo-6-methylpyridine, molecular formula is C6H6IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-Iodo-6-methylpyridine

A mixture of Compound la (55 mg, 0.171 mmol) 2-bromo-6-methylpyridine (23.4 ul, 0.205 mmol), tetrakis(triphenylphosphine)palladium (7.89 mg, 0.007 mmol), sodium acetate (28 mg, 0.342 mmol) and tetrabutylammonium fluoride (44.7 mg, 0.17 1 mmol)) in anhydrous DMF (3 mL) was heated at 110°C into a microwave oven (Biotage Smith Creator®) for 10 mm then cooled at r.t.. The reaction mixture was poured into water and extracted with EtOAc (3x). The organic layer was dried over Na2504 and the solvent was evaporated to dryness to give a crude which was purified via automated flashchromatography (SP1® Biotage, SNAP25 Cartridge), eluting with a EtOAc – PetroleumEther gradient from 75:25 to 1:1 to give mg 51(87.6percent) of the title compound.UPLC-MS [M+H]= 341.521H NMR (400 MHz, DMSO-d6) oe ppm 7.68 (t, 1 H), 7.31 (d, 1 H), 7.22 (d, 1 H), 5.66 (s,1 H), 3.43 (brt, 2 H), 3.15 (s, 2 H), 2.62 (brt, 2 H), 2.45 (s, 3 H), 1.42 (s, 9 H), 1.08 (s, 6H)

With the rapid development of chemical substances, we look forward to future research findings about 62674-71-9.

Reference:
Patent; RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA; RIVA, Carlo; GRAZIANI, Davide; LONGHI, Matteo; CALLEGARI, Elisa; FRIGERIO, Fabio; ANGELICO, Patrizia; (197 pag.)WO2019/2571; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 62674-71-9

With the rapid development of chemical substances, we look forward to future research findings about 62674-71-9.

Simple exploration of 62674-71-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62674-71-9, 2-Iodo-6-methylpyridine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 62674-71-9 ,Some common heterocyclic compound, 62674-71-9, molecular formula is C6H6IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Pyridines substituted at the 2-position with halides shown in Tables 2 and 3 are stirred in a mixture of toluene (900 mL) and anhydrous ether (600 mL). The resulting solutions were cooled to < -100 °C for 20 min at which point n-BuLi/hexane was added slowly over 22 min. After maintaining the temperature below -100 °C for 20 min, triisopropylborate was added dropwise, and then the reaction mixture was stirred below -70 °C. After stirring for 4 h, ether (500 mL) was added and the solution was allowed to stand overnight at room temp. Isopropanol was added (30mL), then the reaction mixture was stirred for 30 min, the allowed to stand without stirring for an additional 2 h. The resulting precipitate was collected by filtration then washed with ethyl ether and dried under nitrogen atmosphere for 1.5 h. The resulting triisopropoxy analog was treated with a mixture of acetone and water (450 mL/50 mL) to remove any contaminating n-butylborate lithium salt. The solids were collected by filtration, washed with acetone/water (9:1, 300 mL), and dried in air for 2h, then lyophilized overnight to afford product. In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62674-71-9, 2-Iodo-6-methylpyridine, other downstream synthetic routes, hurry up and to see. Reference:
Article; Chen, Kuanchiang; Peterson, Richard; Math, Shivanand K.; Lamunyon, James B.; Testa, Charles A.; Cefalo, Dustin R.; Tetrahedron Letters; vol. 53; 36; (2012); p. 4873 – 4876;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 2-Iodo-6-methylpyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62674-71-9, 2-Iodo-6-methylpyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 62674-71-9, 2-Iodo-6-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Iodo-6-methylpyridine, blongs to pyridine-derivatives compound. Safety of 2-Iodo-6-methylpyridine

The title compound was prepared following the procedure reported above for the compound of Example 1 replacing Compound llOa for Compound la and 2-iodo-6-methylpyridine for 3-chlorobenzoyl chloride. After the usual work-up, the reaction crude was purified by automated flash chromatography (SP1® Biotage, 10 g SNAP column) eluting with PE – EtOAc gradient from 9:1 to 6:4 affording the title product as a dense colourless oil (77.8 percent). E/Z mixture 55:45 (1H-NMR).UPLC-MS [M+H]= 353.16, 353.231H NMR (400 MHz, CHLOROFORM-d) mix of isomers oe ppm 7.57 (br s, 2 H), 7.20 – 7.27 (m, 2 H), 7.10 (br d, 2 H), 5.69 (s, 1 H) and 5.62 (s, 1 H), 3.26 – 3.41 (m, 4 H), 2.82 (s, 2 H), 2.59 (br s, 6 H), 2.51 (s, 2 H) and 2.53 (br s,2 H), 2.23 – 2.34 (m, 4 H), 2.21 (m, 2 H) and 1.94 – 2.12 (m, 4 H), 1.62 – 1.81 (m, 4 H), 1.49 (m, 18 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62674-71-9, 2-Iodo-6-methylpyridine, and friends who are interested can also refer to it.

Application of 2-Iodo-6-methylpyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62674-71-9, 2-Iodo-6-methylpyridine, and friends who are interested can also refer to it.