Category: 62734-08-1

《Accelerating proton-coupled electron transfer of metal hydrides in catalyst model reactions》 was written by Liu, Tianfei; Guo, Meiyuan; Orthaber, Andreas; Lomoth, Reiner; Lundberg, Marcus; Ott, Sascha; Hammarstroem, Leif. Product Details of 62734-08-1 And the article was included in Nature Chemistry on August 31 ,2018. The article conveys some information:

Metal hydrides are key intermediates in catalytic proton reduction and dihydrogen oxidation There is currently much interest in appending proton relays near the metal center to accelerate catalysis by proton-coupled electron transfer (PCET). However, the elementary PCET steps and the role of the proton relays are still poorly understood, and direct kinetic studies of these processes are scarce. Here, authors report a series of tungsten hydride complexes as proxy catalysts, with covalently attached pyridyl groups as proton acceptors. The rate of their PCET reaction with external oxidants is increased by several orders of magnitude compared to that of the analogous systems with external pyridine on account of facilitated proton transfer. Moreover, the mechanism of the PCET reaction is altered by the appended bases. A unique feature is that the reaction can be tuned to follow three distinct PCET mechanisms-electron-first, proton-first or a concerted reaction-with very different sensitivities to oxidant and base strength. Such knowledge is crucial for rational improvements of solar fuel catalysts. In addition to this study using 2-(Chloromethyl)-4-methoxypyridine hydrochloride, there are many other studies that have used 2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1Product Details of 62734-08-1) was used in this study.

2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 62734-08-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-(Chloromethyl)-4-methoxypyridine hydrochlorideOn November 15, 2013 ,《Substituent Effects on the Catalytic Activity of Bipyrrolidine-Based Iron Complexes》 appeared in Journal of Organic Chemistry. The author of the article were Olivo, Giorgio; Lanzalunga, Osvaldo; Mandolini, Luigi; Di Stefano, Stefano. The article conveys some information:

The catalytic activity and the selectivity of the new bipyrrolidine-based Fe-(II) complexes L’·Fe(OTf)2 and L”·Fe(OTf)2 (L’ = (S,S’)-N,N’-bis(4-methoxypyrid-2-ylmethyl)-2,2′-bipyrrolidine, L” = (S,S’)-N,N’-bis(4-(ethoxycarbonyl)pyrid-2-ylmethyl)-2,2′-bipyrrolidine) in the oxidation of a series of alkyl and alkenyl hydrocarbons as well as of an aromatic sulfide with H2O2 were tested and compared with the catalytic efficiency of White’s parent complex L·Fe(OTf)2 (L = (S,S’)-N,N’-bis(2-pyridylmethyl)-2,2′-bipyrrolidine) in order to evaluate the sensitivity of the reaction to electronic effects. In addition to this study using 2-(Chloromethyl)-4-methoxypyridine hydrochloride, there are many other studies that have used 2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1Application In Synthesis of 2-(Chloromethyl)-4-methoxypyridine hydrochloride) was used in this study.

2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of 2-(Chloromethyl)-4-methoxypyridine hydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(Chloromethyl)-4-methoxypyridine hydrochlorideOn March 20, 1992, Kohl, Bernhard; Sturm, Ernst; Senn-Bilfinger, Joerg; Simon, W. Alexander; Krueger, Uwe; Schaefer, Hartmann; Rainer, Georg; Figala, Volker; Klemm, Kurt published an article in Journal of Medicinal Chemistry. The article was 《(H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate》. The article mentions the following:

[(Pyridylmethyl)sulfinyl]benzimidazoles I (R = OCF2H, OCH2CF3, OCF2CF2H; R1 = H, OMe; RR1 = OCF2O; R2, R3 = H, Me, OMe) were prepared and tested for (H+,K+)-ATPase inhibitory activity. The aim of this study was to identify compounds with high (H+,K+)-ATPase inhibitory activity in stimulated gastric glands possessing acidic pH, but low reactivity (high chem. stability) at neutral pH as reflected by in vitro (Na+,K+)-ATPase inhibitory activity. The critical influence of substituents flanking the pyridine 4-MeO substituent present in all derivatives was carefully studied. The introduction of a 3-MeO group gave inhibitors possessing a combination of high potency, similar to omeprazole and lansoprazole, but increased stability. As a result I (R = OCF2H, R1 = R3 = H, R2 = OMe; pantoprazole) was selected as a candidate drug and is currently undergoing phase III clin. studies. In the experimental materials used by the author, we found 2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1Name: 2-(Chloromethyl)-4-methoxypyridine hydrochloride)

2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Name: 2-(Chloromethyl)-4-methoxypyridine hydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem