Category: 627501-18-2

Gurak, John A. Jr.’s team published research in Tetrahedron in 2017 | CAS: 627501-18-2

5-Chloro-6-hydroxynicotinaldehyde(cas: 627501-18-2) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 627501-18-2

Gurak, John A. Jr.; Tran, Van T.; Sroda, Miranda M.; Engle, Keary M. published an article in Tetrahedron. The title of the article was 《N-alkylation of 2-pyridone derivatives via palladium(II)-catalyzed directed alkene hydroamination》.Product Details of 627501-18-2 The author mentioned the following in the article:

A selective N-alkylation reaction of 2-pyridones and related heterocycles via intermol. alkene hydroamination is reported. The reaction utilizes palladium(II) acetate as a catalyst and employs a bidentate directing group to dictate the regioselectivity for both unactivated terminal and internal alkenes. High functional group tolerance is observed across a wide range of electronically diverse 2-pyridones and other aza-heterocycles, including 1-hydroxyisoquinoline, 2-hydroxyquinoline, pyridazinone, pyrimidinone, and pyrazinone to obtain the corresponding products, e.g., I (X-ray single crystal structure shown). After reading the article, we found that the author used 5-Chloro-6-hydroxynicotinaldehyde(cas: 627501-18-2Product Details of 627501-18-2)

5-Chloro-6-hydroxynicotinaldehyde(cas: 627501-18-2) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 627501-18-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 627501-18-2

The synthetic route of 627501-18-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 627501-18-2, 5-Chloro-6-hydroxynicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloro-6-hydroxynicotinaldehyde, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Chloro-6-hydroxynicotinaldehyde

General procedure: Unless otherwise stated, the procedure was as follows. To a 1-dram (4 mL) vial equipped with a magnetic stir bar were added Pd(OAc)2 (4.4 mg, 0.02 mmol), alkene (0.2 mmol), acetic acid (6.0 mg, 0.1 mmol), nucleophile (0.3 mmol), and MeCN (0.1 mL). The vial was sealed with an unpunctured TFE septum-covered screw cap, and placed in a heating block that was pre-heated to 120 C. After the designated reaction time, the dark black reaction was purified either by flash column chromatography only or by flash column chromatography followed by an aqueous workup to produce the desired product.

The synthetic route of 627501-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gurak, John A.; Tran, Van T.; Sroda, Miranda M.; Engle, Keary M.; Tetrahedron; vol. 73; 26; (2017); p. 3636 – 3642;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 627501-18-2

The synthetic route of 627501-18-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 627501-18-2, 5-Chloro-6-hydroxynicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloro-6-hydroxynicotinaldehyde, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Chloro-6-hydroxynicotinaldehyde

General procedure: Unless otherwise stated, the procedure was as follows. To a 1-dram (4 mL) vial equipped with a magnetic stir bar were added Pd(OAc)2 (4.4 mg, 0.02 mmol), alkene (0.2 mmol), acetic acid (6.0 mg, 0.1 mmol), nucleophile (0.3 mmol), and MeCN (0.1 mL). The vial was sealed with an unpunctured TFE septum-covered screw cap, and placed in a heating block that was pre-heated to 120 C. After the designated reaction time, the dark black reaction was purified either by flash column chromatography only or by flash column chromatography followed by an aqueous workup to produce the desired product.

The synthetic route of 627501-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gurak, John A.; Tran, Van T.; Sroda, Miranda M.; Engle, Keary M.; Tetrahedron; vol. 73; 26; (2017); p. 3636 – 3642;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem