Category: 628-13-7

Stereocontrolled Synthesis of Halovinylbenziodoxoles by Hydro- and Iodochlorination of Ethynylbenziodoxoles was written by Wu, Junliang;Deng, Xiaozhou;Yoshikai, Naohiko. And the article was included in Chemistry – A European Journal in 2019.Safety of Pyridinehydrochloride This article mentions the following:

Herein, the synthesis of highly substituted and stereochem. well-defined vinylbenziodoxole (VBX) derivatives I [R = 2-thienyl, Ph, 2-FC₆H₄, etc.; R¹ = H, I; stereo = E or Z] through hydrochlorination and iodochlorination of ethynylbenziodoxoles was reported. The hydrochlorination was achieved using pyridine hydrochloride as an HCl source in an anti-fashion under mild, open-air conditions to afford a 2-chlorinated VBX products I [R¹ = H; stereo = Z], which served as a useful building block for the stereoselective synthesis of trisubstituted alkenes. Meanwhile, iodochlorination with iodine monochloride proceeded in an unusual syn-pathway, stereoselectively affording a tetrasubstituted VBX derivatives I [R¹ = I; stereo = Z]. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Characterization, and In Vivo Evaluation of Desmethyl Anethole Trithione Phosphate Prodrug for Ameliorating Cerebral Ischemia-Reperfusion Injury in Rats was written by Huang, Sheng;Dong, Renhan;Xu, Gaojie;Liu, Jin;Gao, Xiaofang;Yu, Siqi;Qie, Pengfan;Gou, Gang;Hu, Min;Wang, Yu;Peng, Jian;Guang, Bing;Xu, Ying;Yang, Tai. And the article was included in ACS Omega in 2020.Safety of Pyridinehydrochloride This article mentions the following:

Anethole trithione (ATT) has a wide range of physiol. activities, but its use is limited due to its poor water solubility To improve the solubility of ATT, we synthesized and characterized a novel phosphate prodrug (ATXP) relying on the availability of the hydroxy group in 5-(4-hydroxyphenyl)-3H-1,2-dithiole3-thione (ATX), which was transformed from ATT rapidly and extensively in vivo. Our results showed that ATXP significantly improved drug solubility ATXP was rapidly converted to ATX and reached a maximum plasma concentration with a T_max of approx. 5 min after i.v. (iv) administration. Furthermore, after the oral administration of ATXP, the C_max was 3326.30 鍗?566.50 ng/mL, which was approx. 5-fold greater than that of the parent drug form, indicating that ATXP has greater absorption than that of ATT. Addnl., the oral phosphate prodrug ATXP increased the ATX in the area under the plasma concentration vs time curves (AUC_0-t = 3927.40 鍗?321.50 and AUC_{0-閳?/sub> = 4579.0 鍗?756.30), making its use in practical applications more meaningful. Finally, compared to the vehicle, ATXP was confirmed to maintain the bioactivity of the parent drug for a significant reduction in infarct volume 24 h after reperfusion. Based on these findings, the phosphate prodrug ATXP is a potentially useful water-soluble prodrug with improved pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).}

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An interpenetrating network poly(diethylene glycol carbonate)-based polymer electrolyte for solid state lithium batteries was written by Liu, Xiaochen;Ding, Guoliang;Zhou, Xinhong;Li, Shizhen;He, Weisheng;Chai, Jingchao;Pang, Chunguang;Liu, Zhihong;Cui, Guanglei. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2017.Related Products of 628-13-7 This article mentions the following:

Polycarbonate-based polymer electrolytes possess superior ionic conductivity at room temperature, higher Li ion transference number and wider electrochem. stability window when compared with conventional poly(ethylene oxide)-based polymer electrolytes. Here, the poly(diethylene glycol carbonate) dimethacrylate macromonomer (PDEC-DMA) was synthesized and the resultant interpenetrating network IPN-PDEC polymer electrolyte was developed via free radical in situ polymerization for polymer electrolyte Li metal batteries. This IPN-PDEC polymer electrolyte exhibited a decent ionic conductivity of 1.64 鑴?10^-4 S/cm at room temperature and a wide electrochem. stability window (閳?.5 V vs. Li⁺/Li). The LiFePO₄/IPN-PDEC/Li and LiFe_0.2Mn_0.8PO₄/IPN-PDEC/Li cells delivered excellent rate capability and cycling performance at room temperature An all solid state Li battery was also demonstrated by applying the as-prepared solid polymer electrolyte (SPE-PDEC) at 100鎺? which displayed a superior cycling performance. Therefore, the IPN-PDEC network is a promising polymer electrolyte for solid state Li batteries. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Related Products of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Utilizing Selective Chlorination to Synthesize New Triangulenium Dyes was written by Jensen, Jesper Dahl;Bisballe, Niels;Kacenauskaite, Laura;Thomsen, Maria Storm;Chen, Junsheng;Hammerich, Ole;Laursen, Bo W.. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of Pyridinehydrochloride This article mentions the following:

Functionalization of new sites on the triangulenium structure has been achieved by early stage chlorination with N-chlorosuccinimide (NCS), giving rise to two new triangulenium dyes (1 and 3). By introducing the chlorine functionalities in the acridinium precursor, positions complementary to those previously accessed by electrophilic aromatic substitution on the final dyes are accessed. The chlorination is selective, giving only one regioisomer for both mono- and dichlorination products. For the monochlorinated acridinium compound a highly selective ring-closing reaction was discovered, generating a single regioisomer of the cationic [4]helicene product. Further investigations into the mechanism of [4]helicene formation lead to the first isolation of the previously proposed intermediate of the two-step S_NAr reaction, key to all aza-bridged triangulenium and helicenium systems. Late-stage functionalization of DAOTA⁺ with NCS gave rise to a different dichlorinated compound (2). The fully ring closed chlorinated triangulenium dyes 1, 2 and 3 show red shift in absorption and emission, while maintaining relatively high fluorescence quantum yields of 36%, 26%, and 41%, and long fluorescence lifetimes of 15 ns, 12.5 and 16 ns, resp. Cyclic voltammetry shows that chlorination of the triangulenium dyes significantly lowers reduction potentials and thus allows for efficient tuning of redox and photoredox properties. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Quality Control of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cyclometalated Iron and Ruthenium Complexes Supported by a Tetradentate Ligand Scaffold with Mixed O, N, and C Donor Atoms: Synthesis, Structures, and Excited-State Properties was written by Law, Kwok-Chung;Tang, Zhou;Wu, Liangliang;Wan, Qingyun;To, Wai-Pong;Chang, Xiaoyong;Low, Kam-Hung;Liu, Yungen;Che, Chi-Ming. And the article was included in Organometallics in 2022.Name: Pyridinehydrochloride This article mentions the following:

Cyclometalated Fe(II/III) and Ru(II/III) complexes bearing a tetradentate dianionic [O-N-C-N] ligand (H₂[O-N-C-N] = 2-(6-(3-(pyridin-2-yl)phenyl)pyridin-2-yl)phenol) were synthesized and structurally characterized. The strong-field dianionic [O-N-C-N] ligand enforces all of these complexes in low-spin state at 298 K as revealed by ¹H NMR, magnetic susceptibility, and EPR measurements. A 77 K 2-MeTHF glassy solution of the bis(arylisocyanide) Ru(II) complex [Ru^II(O-N-C-N)(XylNC)₂] displays a weak and broad emission band (浣?sub>em: 680 nm; 锜? 0.27娓璼) while the others are nonemissive. DFT/TDDFT calculations revealed that ¹dd excited states of the d⁶ [M(II)(O-N-C-N)(PMe₃)₂] (M = Fe, Ru) are strongly destabilized. The [Fe(II)(O-N-C-N)(PMe₃)₂] exhibits panchromatic absorption up to 850 nm. A combined study of fs-TA, spectroelectrochem., and theor. calculation revealed that the possible ³MLCT excited state (锜? 14 ps) of [Fe(II)(O-N-C-N)(PMe₃)₂] decays via a lower-lying ³dd excited state. For the d⁵ [M(III)(O-N-C-N)(PMe₃)₂]⁺ (M = Fe, Ru), the presence of low-lying ²dd excited states and ²LMCT states with short lifetimes (锜? 11.7-12.6 ps) is suggested. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Name: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Name: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Straightforward synthesis of diverse dipyrazolylmethane derivatives and their application for fluorescence sensing of Cu²⁺ ions was written by Kaliraj, Kaliappan;Xia, Likai;Edison, Thomas Nesakumar Jebakumar Immanuel;Lee, Yong Rok. And the article was included in RSC Advances in 2016.Reference of 628-13-7 This article mentions the following:

A variety of dipyrazolylmethane derivatives were synthesized from the reactions of readily available 灏?keto esters with arylhydrazine hydrochlorides and DMF in the presence of p-toluenesulfonic acid (p-TsOH). This methodol provides a concise and practical one-pot route for the construction of diverse dipyrazolylmethane derivatives in good yield. As an application, the synthesized nitro-substituted compound displayed an excellent turn-off fluorescence sensing property for the detection of Cu²⁺ ions. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Reference of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions of a cerium(III) amide with heteroallenes: insertion, silyl-migration and de-insertion was written by Yin, Haolin;Carroll, Patrick J.;Schelter, Eric J.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Synthetic Route of C5H6ClN This article mentions the following:

Reactions of Ce[N(SiMe₃)Ph^F]₃ (-Ph^F = pentafluorophenyl) toward small mols. of the type E₁=C=E₂ (E₁, E₂ = O, S, NR), including carbon disulfide, carbodiimide, carbon dioxide, isocyanate and isothiocyanate are reported, resulting in distinct products, including cerium(III) dithiocarbamate, cerium(III) guanidinate, isocyanates and unsym. carbodiimides. These reactions were rationalized as three consecutive stages of the same reaction pathway: insertion, silyl-migration and de-insertion. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Synthetic Route of C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Biocorrosion of metal sewage treatment constructions and its inhibition with pyridinium chlorides was written by Bondar, Olena;Kurmakova, Iryna;Polevichenko, Sergey;Demchenko, Nataliya. And the article was included in Chemistry & Chemical Technology in 2017.Category: pyridine-derivatives This article mentions the following:

On the metal sewage treatment constructions (Chernihiv, Ukraine) a biofilm is formed, which is corrosive because of the number of sulfate-reducing bacteria (10⁷ cell/cm²). By affecting sulfate-reducing activity of microorganisms, pyridinium chlorides at the concentration of 0.5 g/l were revealed to provide St3ps steel inhibition efficiency of up to 98.7% under the corrosion caused by biofilm bacteria. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Category: pyridine-derivatives).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Valorization of chitin derived N-acetyl-D-glucosamine into high valuable N-containing 3-acetamido-5-acetylfuran using pyridinium-based ionic liquids was written by Zang, Hongjun;Lou, Jing;Jiao, Shuolei;Li, Huanxin;Du, Yannan;Wang, Jiao. And the article was included in Journal of Molecular Liquids in 2021.Safety of Pyridinehydrochloride This article mentions the following:

A series of pyridinium-based ionic liquids were synthesized to directly catalyze the conversion of N-acetyl-D-glucosamine (NAG, the monomer of chitin) to 3-acetamido-5-acetylfuran (3A5AF). The yield of 3A5AF in 1-carboxymethyl pyridinium chloride ionic liquid reached 37.49%, without any additives. Using B₂O₃ and CaCl₂ as additives, the optimum yield increased to 67.37% at 180鎺矯 in 20 min. In addition, HPLC-MS anal. was utilized to elucidate the reaction mechanism. The research on turning “waste” into “wealth” opens up new ways for the utilization of biomass waste, which not only reduces environmental pollution but also has potential economic value. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efficient total synthesis of neocryptolepine and synthetic access to 6-methylquinindoline from a common intermediate was written by Mendez, Maria V.;Heredia, Daniel A.;Larghi, Enrique L.;Bracca, Andrea B. J.;Kaufman, Teodoro S.. And the article was included in RSC Advances in 2017.SDS of cas: 628-13-7 This article mentions the following:

A convenient approach toward the indoloquinolines neocryptolepine and 6-methylquinindoline from a common intermediate, is reported. Both sequences, designed for maximum use of accessible reagents and robust conditions, are straightforward and efficient. They involved the amidation of 2-aminobenzaldehyde (prepared by iron-mediated reduction of 2-nitrobenzaldehyde) with 2-nitrophenylacetic acid, followed by a K₂CO₃-assisted cyclization to form a 3-(2-nitrophenyl)quinolin-2-one as the common precursor. Me₂CO₃-mediated N-methylation of the lactam, reduction of the nitro moiety and final cyclization resulted in 55% overall yield of neocryptolepine, whereas cyclocondensation and N-methylation afforded 79% overall yield of 6-Me quinindoline. Thus, the sequences toward the targets entailed two POCl₃-promoted C-N bond forming reactions, two Fe-mediated nitro group reductions and two base-promoted transformations. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7SDS of cas: 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem