Category: 628-13-7

Synthesis of Molybdenum and Tungsten Alkylidene Complexes that Contain a tert-Butylimido Ligand was written by Jeong, Hyangsoo;Schrock, Richard R.;Muller, Peter. And the article was included in Organometallics in 2015.Synthetic Route of C5H6ClN This article mentions the following:

A variety of Mo or W complexes that contain a tert-butylimido ligand were prepared For example, the o-methoxybenzylidene complex W(N-t-Bu)(CH-o-MeOC₆H₄)(Cl)₂(py) was prepared through addition of pyridinium chloride to W(N-t-Bu)₂(CH₂-o-MeOC₆H₄)₂, while Mo(N-t-Bu)(CH-o-MeOC₆H₄)(OR_F)₂(t-BuNH₂) complexes (OR_F = OC₆F₅ or OC(CF₃)₃) were prepared through addition of two equivalent of R_FOH to Mo(N-t-Bu)₂(CH₂-o-MeOC₆H₄)₂. An x-ray crystallog. study of Mo(N-t-Bu)(CH-o-MeOC₆H₄)[OC(CF₃)₃]₂(t-BuNH₂) showed that the methoxy O is bound to the metal and that two protons on the tert-butylamine ligand are only a short distance away from one of the CF₃ groups on one of the perfluoro-tert-butoxide ligands (H···F = 2.456(17) and 2.467(17) Å). Other synthesized W tert-butylimido complexes include W(N-t-Bu)(CH-o-MeOC₆H₄)(pyr)₂(2,2′-bipyridine) (pyr = pyrrolide), W(N-t-Bu)(CH-o-MeOC₆H₄)(pyr)(OHMT) (OHMT = O-2,6-(mesityl)₂C₆H₃), W(N-t-Bu)(CH-t-Bu)(OHMT)(Cl)(py) (py = pyridine), W(N-t-Bu)(CH-t-Bu)(OHMT)(Cl), W(N-t-Bu)(CH-t-Bu)(pyr)(ODFT)(py), W(N-t-Bu)(CH-t-Bu)(OHMT)₂, and W(N-t-Bu)(CH-t-Bu)(ODFT)₂(ODFT = O-2,6-(C₆F₅)₂C₆H₃). W(N-t-Bu)(CH-t-Bu)(OHMT)₂ does not react with ethylene or 2,3-dicarbomethoxynorbornadiene. Removal of pyridine from W(N-t-Bu)(CH-t-Bu)(Biphen_CF3)(pyridine) (Biphen_CF3 = 3,3′-di-tert-butyl-5,5′-bistrifluoromethyl-6,6′-dimethyl-1,1′-biphenyl-2,2′-diolate) with B(C₆F₅)₃ gave a five-coordinate 14e neopentyl complex as a consequence of CH activation in one of the Me groups in one tert-Bu group of the Biphen_CF3 ligand, as was proven in an x-ray study. An attempted synthesis of W(N-t-Bu)(CH-t-Bu)(Biphen_Me) (Biphen_Me = 3,3′-di-tert-butyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diolate) gave a 1:1 mixture of W(N-t-Bu)(CH-t-Bu)(Biphen_Me) and a neopentyl complex analogous to the one characterized through an x-ray study. The metallacyclobutane complexes W(N-t-Bu)(C₃H₆)(pyrrolide)(ODFT) and W(N-t-Bu)(C₃H₆)(ODFT)₂ were prepared in reactions involving W(N-t-Bu)(CH-t-Bu)(pyr)₂(bipy), ZnCl₂(dioxane), and one or two equivalent of DFTOH, resp., under 1 atm of ethylene. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Synthetic Route of C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Automated and accelerated synthesis of indole derivatives on a nano-scale was written by Shaabani, Shabnam;Xu, Ruixue;Ahmadianmoghaddam, Maryam;Gao, Li;Stahorsky, Martin;Olechno, Joe;Ellson, Richard;Kossenjans, Michael;Helan, Victoria;Doemling, Alexander. And the article was included in Green Chemistry in 2019.Safety of Pyridinehydrochloride This article mentions the following:

For the first time use of acoustic droplet ejection technol. and fast quality control was described to screen the efficiency of synthetic reactions on a nanomole scale in an automated and miniaturized fashion. The interrupted Fischer indole combined with Ugi-type reactions yielded several attractive drug-like indole scaffolds such as I [R¹ = H, 5-Me, 4,6-di-Me, 5-MeO, 7-Br; R² = Me, Et, ; R³ = Me, Et; R²R³ = (CH₂)₅, (CH₂)₂O(CH₂)₂, (CH₂)₂NBoc(CH₂)₂; R⁴ = i-Pr, cyclohexyl, 4-MeOC₆H₄, etc.; R⁵ = t-Bu, 2-pyrrolyl, 2-indolyl, etc.], tetrazole II and imino hadantoin e.g., III. In 384-well plates, a diverse set of interrupted Fischer indole intermediates were produced and reacted with the tricyclic hydantoin backbone in a 2-step sequence. Similarly, preformed Fischer indole intermediates were used to produce diverse sets of Ugi products and the efficiency was compared with that of the in situ method. Multiple reactions were performed again on a preparative millimole scale, showing scalability from nano to mg and thus synthetic utility. An unprecedented large number of building blocks were used for fast scope and limitation studies (68 isocyanides, 72 carboxylic acids). Miniaturization and anal. of the generated big synthesis data enabled deeper exploration of the chem. space and permitted the gain of knowledge that was previously impractical or impossible, such as the rapid survey of reactions and building block and functional group compatibility. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

C-H···Anion Interactions Assisted Addition of Water to Glycals by Sterically Hindered 2,4,6-Tri-tert-butylpyridinium Hydrochloride was written by Mukherji, Ananya;Kancharla, Pavan K.. And the article was included in Organic Letters in 2020.HPLC of Formula: 628-13-7 This article mentions the following:

The conjugate acid of the bulky base 2,4,6-tri-tert-butylpyridine, under mild conditions, catalyzes the synthesis of silyl-protected 2-deoxy-hemiacetals and their dimerized products from glycals at varying concentrations of water. The criticality of the concentration of water in the reaction outcome is indicative of a unique mechanistic pathway for the bulky pyridine salt and not via the general Bronsted acid mechanism. The various silyl-protected hemiacetals thus synthesized were successfully utilized in the stereoselective synthesis of both α and β glycosides. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7HPLC of Formula: 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Enzyme-like Supramolecular Iridium Catalysis Enabling C-H Bond Borylation of Pyridines with meta-Selectivity was written by Trouve, Jonathan;Zardi, Paolo;Al-Shehimy, Shaymaa;Roisnel, Thierry;Gramage-Doria, Rafael. And the article was included in Angewandte Chemie, International Edition in 2021.Application In Synthesis of Pyridinehydrochloride This article mentions the following:

The use of secondary interactions between substrates and catalysts is a promising strategy to discover selective transition metal catalysts for atom-economy C-H bond functionalization. The most powerful catalysts are found via trial-and-error screening due to the low association constants between the substrate and the catalyst in which small stereo-electronic modifications within them can lead to very different reactivities. To circumvent these limitations and to increase the level of reactivity prediction in these important reactions, the authors report herein a supramol. catalyst harnessing Zn···N interactions that binds to pyridine-like substrates as tight as it can be found in some enzymes. The distance and spatial geometry between the active site and the substrate binding site is ideal to target unprecedented meta-selective iridium-catalyzed C-H bond borylations with enzymic Michaelis-Menten kinetics, besides unique substrate selectivity and dormant reactivity patterns. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application In Synthesis of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application In Synthesis of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Supercoiled fibres of self-sorted donor-acceptor stacks: a turn-off/turn-on platform for sensing volatile aromatic compounds was written by Sandeep, Anjamkudy;Praveen, Vakayil K.;Kartha, Kalathil K.;Karunakaran, Venugopal;Ajayaghosh, Ayyappanpillai. And the article was included in Chemical Science in 2016.Recommanded Product: 628-13-7 This article mentions the following:

To ensure the comfortable survival of living organisms, detection of different life threatening volatile organic compounds (VOCs) such as biol. metabolites and carcinogenic mols. is of prime importance. Herein, we report the use of supercoiled supramol. polymeric fibers of self-sorted donor-acceptor mols. as “turn-off/turn-on” fluorescent sensors for the detection of carcinogenic VOCs. For this purpose, a C₃-sym. donor mol. based on oligo(p-phenylenevinylene), C₃OPV, and a perylene bisimide based acceptor mol., C₃PBI, have been synthesized. When these two mols. were mixed together in toluene, in contrast to the usual charge transfer (CT) stacking, supramol. fibers of self-sorted stacks were formed at the mol. level, primarily driven by their distinct self-assembly pathways. However, CT interaction at the macroscopic level allows these fibers to bundle together to form supercoiled ropes. An interfacial photoinduced electron transfer (PET) process from the donor to the acceptor fibers leads to an initial fluorescence quenching, which could be modulated by exposure to strong donor or acceptor type VOCs to regenerate the resp. fluorescence of the individual mol. stacks. Thus, strong donors could regenerate the green fluorescence of C₃OPV stacks and strong acceptors could reactivate the red fluorescence of C₃PBI stacks. These supercoiled supramol. ropes of self-sorted donor-acceptor stacks provide a simple tool for the detection of donor- or acceptor-type VOCs of biol. relevance, using a “turn-off/turn-on” fluorescence mechanism as demonstrated with o-toluidine, which has been reported as a lung cancer marker. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Recommanded Product: 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor was written by Rein, Jonas;Annand, James R.;Wismer, Michael K.;Fu, Jiantao;Siu, Juno C.;Klapars, Artis;Strotman, Neil A.;Kalyani, Dipannita;Lehnherr, Dan;Lin, Song. And the article was included in ACS Central Science in 2021.Product Details of 628-13-7 This article mentions the following:

Organic electrochem. has emerged as an enabling and sustainable technol. in modern organic synthesis. Despite the recent renaissance of electrosynthesis, the broad adoption of electrochem. in the synthetic community, and especially in industrial settings, has been hindered by the lack of general, standardized platforms for high-throughput experimentation (HTE). Herein, we disclose the design of the HTe^–Chem, a high-throughput microscale electrochem. reactor that is compatible with existing HTE infrastructure and enables the rapid evaluation of a broad array of electrochem. reaction parameters. Utilizing the HTe^–Chem to accelerate reaction optimization, reaction discovery, and chem. library synthesis is illustrated using a suite of oxidative and reductive transformations under constant current, constant voltage, and electrophotochem. conditions. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Product Details of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identification of interleukin-8-reducing lead compounds based on SAR studies on dihydrochalcone-related compounds in human gingival fibroblasts (HGF-1 cells) in vitro was written by Schueller, Katharina;Hans, Joachim;Pfeiffer, Stefanie;Walker, Jessica;Ley, Jakob P.;Somoza, Veronika. And the article was included in Molecules in 2020.Quality Control of Pyridinehydrochloride This article mentions the following:

In order to identify potential activities against periodontal diseases, eighteen dihydrochalcones and structurally related compounds were tested in an established biol. in vitro cell model of periodontal inflammation using human gingival fibroblasts (HGF-1 cells). Subsequently to co-incubation of HGF-1 cells with a bacterial endotoxin (Porphyromonas gingivalis lipopolysaccharide, pgLPS) and each individual dihydrochalcone in a concentration range of 1 μM to 100 μM, gene expression of interleukin-8 (IL-8) was determined by qPCR and cellular interleukin-8 (IL-8) release by ELISA. Structure-activity anal. based on the dihydrochalcone backbone and various substitution patterns at its aromatic ring revealed moieties 2′,4,4′,6′-tetrahydroxy 3-methoxydihydrochalcone (7) to be the most effective anti-inflammatory compound, reducing the pgLPS-induced IL-8 release concentration between 1 μM and 100 μM up to 94%. In general, a 2,4,6-trihydroxy substitution at the A-ring and concomitant vanilloyl (4-hydroxy-3-methoxy) pattern at the B-ring revealed to be preferable for IL-8 release inhibition. Furthermore, the introduction of an electroneg. atom in the A,B-linker chain led to an increased anti-inflammatory activity, shown by the potency of 4-hydroxybenzoic acid N-vanillylamide (13). Our data may be feasible to be used for further lead structure designs for the development of potent anti-inflammatory additives in oral care products. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Quality Control of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hydrogen bond hierarchy: Persistent phenol···chloride hydrogen bonds in the presence of carboxylic acid moieties was written by Duggirala, Naga Kiran;Wood, Geoffrey P. F.;Fischer, Addison;Wojtas, Lukasz;Perry, Miranda L.;Zaworotko, Michael J.. And the article was included in Crystal Growth & Design in 2015.Quality Control of Pyridinehydrochloride This article mentions the following:

Crystal engineering strategies have been delineated during the past decade for the design of multi-component mol. crystals (mol. cocrystals, MCCs). However, the same depth of understanding has not yet been established for cocrystals that are comprised of at least one ionic compound (ionic cocrystals, ICCs). We address this long known but understudied class of cocrystals through the use of organic cation chloride salts as cocrystal formers with carboxylic acids and phenols. Such ICCs are of particular interest for both fundamental and applied reasons. With respect to the former, carefully selected mol. cocrystal formers (coformers) enable systematic study of the hierarchy of hydrogen bonds. With respect to the latter, chloride anions, phenol groups, and carboxylic acid moieties are prevalent in biol. active drug substances and nutraceuticals. In this contribution, we evaluated the propensity to form chloride···carboxylic acid vs chloride···phenol hydrogen bonds (supramol. heterosynthons) through a combination of Cambridge Structural Database (CSD) data mining and the structural characterization of 12 novel ICCs, including 4 hydrates containing carboxylic acids, phenol groups, and chloride anions. Our anal. of these 12 ICCs and the 9 relevant entries (including 4 hydrates) archived in the CSD reveals that charge-assisted hydrogen bonds between phenol moieties and chloride anions persist even in the presence of carboxylic acid moieties, which form carboxylic acid dimers in 11/21 crystal structures. Carboxylic acid···chloride supramol. heterosynthons occur in just 4/21 structures. These observations are supported by lattice energy calculations and hydrogen bond strengths derived from d. functional theory calculations That phenol groups are better suited than carboxylic acid moieties to form ionic cocrystals with chloride salts has important implications for the design of drug substances with improved properties since chloride salts are so prevalent as drug substances. This observation also questions the widespread reliance upon pK_a values to predict hydrogen bond strengths. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Quality Control of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Protonation Studies of Molybdenum(VI) Nitride Complexes That Contain the [2,6-(ArNCH₂)₂NC₅H₃]^2- Ligand (Ar = 2,6-Diisopropylphenyl) was written by Hickey, Anne K.;Wickramasinghe, Lasantha A.;Schrock, Richard R.;Tsay, Charlene;Muller, Peter. And the article was included in Inorganic Chemistry in 2019.Safety of Pyridinehydrochloride This article mentions the following:

[Ar₂N₃]Mo(N)(O-t-Bu) (1), which contains the conformationally rigid pyridine-based diamido ligand [2,6-(ArNCH₂)₂NC₅H₃]^2- (Ar = 2,6-diisopropylphenyl), is a catalyst for the reduction of dinitrogen with protons and electrons. Various acids have been added in order to explore where and how the first proton adds to the complex. The addition of adamantol to 1 produces a five-coordinate bis(adamantoxide), [HAr₂N₃]Mo(N)(OAd)₂ (2a), in which one of the amido nitrogens in the ligand has been protonated and the resulting aniline nitrogen in the [HAr₂N₃]^– ligand is not bound to the metal. The addition of [Ph₂NH₂][OTf] to 1 produces {[HAr₂N₃]Mo(N)(O-t-Bu)}(OTf) (3), in which an amido nitrogen has been protonated, but the aniline in the [HAr₂N₃]^– ligand remains bound to the metal. Last, the addition of (2,6-lutidinium)BAr^F₄ (BAr^F₄ = {B(3,5-(CF₃)₂C₆H₃)₄}^–) to 1 yields {[Ar₂N₃]Mo(N)(LutH)(O-t-Bu)}BAr^F₄, in which LutH⁺ is hydrogen-bonded to the nitride in the solid state and in dichloromethane with K_eq = 412 ± 94 and ΔG = -3.6 ± 0.8 kcal at 22 °C. A similar hydrogen-bonded adduct was formed through the addition of (2-methylpyridinium)BAr^F₄ to 1, but the addition of (pyridinium)BAr^F₄ to 1 leads to the formation of (inter alia) {[HAr₂N₃]Mo(N)(O-t-Bu)}(BAr^F₄), in which the amide nitrogen has been protonated. The addition of cobaltocene to 3 or {[Ar₂N₃]Mo(N)(LutH)(O-t-Bu)}(BAr^F₄) leads only to the re-formation of 1. X-ray structural studies were carried out on 2a, 3, and {[Ar₂N₃]Mo(N)(LutH)(O-t-Bu)}(BAr^F₄). In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Two-step solid-state synthesis of PEPPSI-type compounds was written by Adams, Christopher J.;Lusi, Matteo;Mutambi, Emily M.;Guy Orpen, A.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Formula: C5H6ClN This article mentions the following:

The two-step mechanochem. preparation of carbene-pyridine complexes of palladium and platinum is reported. The organometallic products, which represent a class of com. available catalysts, are rapidly formed in excellent yield proving solvent-free synthesis to be a viable synthetic alternative even in the case of NHC-containing compounds In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Formula: C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem