Adding a certain compound to certain chemical reactions, such as: 628-13-7, Pyridinehydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 628-13-7, blongs to pyridine-derivatives compound. 628-13-7
This material was dissolved in methanol and 5 mL of saturated HCl in ethyl acetate was added and concentrated to give the hydrochloride salt. To 2 g of the above pyridine hydrochloride salt in 15 mL of methanol was added 0.225 g of platinum oxide and hydrogenated at 50 psi on the Parr shaker for 2 h. The catalyst was filtered off through a pad of celite and washed with methanol. The filtrate was concentrated to give 2.17 of the piperidine hydrochloride as a foam. STR123 The title compound was prepared from the compound made in Step A and Intermediate 3 as described previously. 1 H NMR (400 MHz, CD3 OD mixture of rotamers): 8.10 (t, 1H), 7.78 (dd, 1H), 7.50-7.00 (m, 8H), 4.90 (m, 1H), 4.55 (d, 1H), 3.94 and 3.90 (2 doublets, 1H), 3.85 (s, 3H), 3.80-3.60 (m, 1H), 3.05 (dt, 1H), 2.70-2.50 (m, 4H), 1.90-1.50 (m, 6H), 1.55 (s, 3H), 1.50 9s, 3H), 1.40 (m, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,628-13-7, its application will become more common.
Reference:
Patent; Merck & Co., Inc.; US5492920; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem