Electric Literature of 6302-02-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6302-02-9 as follows.
EXAMPLE 19 2-Guanidino-4-methyl-5-(2-pyridyl)thiazole (0.16 g) was obtained according to substantially the same manner as that of Example 17 from 1-(2-pyridyl)acetone (2.8 g) and N-amidinothiourea (1.18 g). mp 166-168 C. IR (Nujol): 3440, 3400, 3270, 3080, 1630, 1600, 1580, 1540, 1520, 1420, 1320, 1240 cm-1 NMP (DMSO-d6, delta): 2.42 (3H, s), 6.8-7.1 (1H, m), 7.36 (1H, d, J=7 Hz), 7.5-7.8 (1H, m), 8.33 (1H, d d., J=2 Hz, 7 Hz) Mass. 233 (M+)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6302-02-9, its application will become more common.
Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4649146; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem