Category: 63071-13-6

Electric Literature of 63071-13-6 , The common heterocyclic compound, 63071-13-6, name is 4-Chloropicolinaldehyde, molecular formula is C6H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A single-neck round bottomed flask was charged with dioxane/ H2O (3/1), picolinaldehyde 16 (536mg, 5.0mmol), methyl acrylate (0.54mL, 6.0mmol) and DABCO (34mg, 0.3mmol). The reaction mixture stirred at room temperature for 3h. Then the reaction solution was concentrated under reduced pressure and the residue was purified by silica gel column chromatography eluting with petroleum ether/ethyl acetate (3/1) to afford 0.43g of 17 as dark yellow oil. Yield: 44.7%.

The synthetic route of 63071-13-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xue, Yu; Tang, Jingshu; Ma, Xiaozhuo; Li, Qing; Xie, Bingxue; Hao, Yuchen; Jin, Hongwei; Wang, Kewei; Zhang, Guisen; Zhang, Liangren; Zhang, Lihe; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 94 – 108;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 63071-13-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63071-13-6, name is 4-Chloropicolinaldehyde, molecular formula is C6H4ClNO, molecular weight is 141.56, as common compound, the synthetic route is as follows.

Step 1. Preparation of 4-(2-((1R,2R)-2-hydroxycyclohexylamino)benzo[d]thiazol-6-yloxy)picolinaldehyde To the reaction mixture of 2-((1R,2R)-2-hydroxycyclohexylamino)benzo[d]thiazol-6-ol (90 mg, 0.34 mmol) in 1.9 ml of NMP was added Cesium Carbonate (232 mg, 0.71 mmol) and 4-chloropicolinaldehyde (125 mg, 0.883 mmol). The reaction mixture was stirred at RT. for 10 minutes and then microwaved at 150 C. for 750 seconds. The crude reaction mixture was filtered, purified on prep HPLC and lyophilized to give 4-(2-((1R,2R)-2-hydroxycyclohexylamino)benzo[d]thiazol-6-yloxy)picolinaldehyde as TFA salt (88 mg). ES/MS m/z 388.1 (MH+) as the hydrate (+18).

The chemical industry reduces the impact on the environment during synthesis 63071-13-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Novartis AG; US2008/45528; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 63071-13-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63071-13-6, name is 4-Chloropicolinaldehyde, molecular formula is C6H4ClNO, molecular weight is 141.56, as common compound, the synthetic route is as follows.

A mixture of A-i (1.5 g, 10.6 mmol) and 4-methylbenzene- sulfonohydrazide (1.97 g, 10.6 mmol) in methanol (15 mL) was stirred at 20C for 3 hours.The solid was collected by filtration, washed with MeOH (3 mL), and dried in oven to afford A-2 (2400 mg, 7.75 mmol) as a solid. ?H NMR (400MHz, DMSO-d6) oH = 11.96 (s, 1H), 8.53 (d, 1H), 7.90 (s, 1H), 7.78 (d, 2H), 7.71 (d, JH), 7.53 (dd, IH), 7.43 (d, 2H), 2.37 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 63071-13-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (120 pag.)WO2019/35951; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 63071-13-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 63071-13-6, name is 4-Chloropicolinaldehyde. A new synthetic method of this compound is introduced below.

Preparation of 4-chloro-2-(difluoromethyl)pyridine: To a solution of 4-chloropicolinaldehyde (1.0 grams, 7.06 mmol) in anhydrous CH2Cl2 (40 mL) cooled to -78 C was added Diethylaminosulfur trifluoride (3.7 mL, 28.2 mmol) over a 2 minute period. The solution was warmed to room temperature and stirred for 4 hours. The reaction mixture was cooled to 0 C, and was slowly quenched with the addition of a 1:1 mixutre of aquoues NaHCO3 (sat.) and 1M NaOH. The solution was extracted with CH2Cl2 (2x), and the organic layer was washed with water, brine, dried (Na2SO4) and concentrated to obtain a red brown oil (0.78 g, 68% yield). The product was used as is in the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63071-13-6, its application will become more common.

Reference:
Patent; GlaxoSmithKline LLC; VU, Chi, B.; DISCH, Jeremy, S.; SPRINGER, Stephanie, K.; BLUM, Charles, A.; PERNI, Robert, B.; (212 pag.)EP2273992; (2016); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem