Category: 63237-88-7

Application of 63237-88-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 63237-88-7 as follows.

To a solution of pyrazolo[1 ,5-a]pyridine-2-carboxylic acid (0.202 g; 1.246 mmol) in dichloromethane (2 mL) were added HATU (0.472 g; 1.241 mmol) and DIPEA (0.450 mL; 2.577 mmol). After stirring for 5 min at room temperature, Lambda/,Omicron-dimethylhydroxylamine hydrochloride (0.128 g; 1.312 mmol) was added and the reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with dichloromethane and washed with water. The phases were separated. The organic phase was washed with a 1 N hydrochloric acid solution, a 1 N sodium bicarbonate solution and brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give N-methoxy-N-methylpyrazolo[1 ,5-a]pyridine-2- carboxamide which was used in the next step without further purification. ESI/APCI (+): 206 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63237-88-7, its application will become more common.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 63237-88-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 63237-88-7 as follows.

General procedure: A solution of P(OMe)3 (1.5mmol) in DCM (10mL) was cooled with an ice bath, then I2 (1.5mmol) was added. After the solid iodine was completely dissolved, corresponding acid (1.2mmol) and Et3N (3.0mmol) were added in sequential order, and the solution was stirred for 15min in a cooling bath. Intermediate 5 (1.0mmol) was added and the mixture was stirred for 15min. After removing the cooling bath, the reaction mixture was stirred for 3.5hat room temperature, then diluted with saturated aqueous NaHCO3 and extracted with DCM (10mL) three times. The combined organic layer was sequentially washed with water and brine, dried with anhydrous Na2SO4, and concentrated in vacuo. The crude was purified by column chromatography with DCM/methanol (100:1 to 50:1, v/v) to give the product as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63237-88-7, its application will become more common.

Reference:
Article; Bai, Renren; Shi, Qi; Liang, Zhongxing; Yoon, Younghyoun; Han, Yiran; Feng, Amber; Liu, Shuangping; Oum, Yoonhyeun; Yun, C. Chris; Shim, Hyunsuk; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 464 – 475;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 63237-88-7, Pyrazolo[1,5-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 63237-88-7, blongs to pyridine-derivatives compound. Product Details of 63237-88-7

To a stirred solution of compound A (500 mg, 3.08 mmol, 1 eq) in CH2CI2 (15 ml) was added thionyl chloride (0.665 ml, 9.25 mmol, 3 eq) and the mixture was refluxed for 3 h. The mixture was cooled to RT, concentrated in vacuo and the residue was dissolved in CH2CI2 (20 ml). TEA (3 ml, 21.51 mmol, 7 eq) followed by Weinreb amine salt (450 mg, 4.62 mmol, and 1.5 eq) was added to it and the resulting mixture was stirred at 23 C for 16 h. The reaction mixture was diluted with ethyl acetate (150 ml), the combined organic layer was washed with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. The crude material was purified by column chromatography to obtain compound B (400 mg, 63 %) as liquid compound. (0425) [0402] FontWeight=”Bold” FontSize=”10″ H NMR (DMSO-d6) delta 8.72-8.70 (d, / = 8 Hz, 1 H), 7.76-7.74 (d, / = 9 Hz, 1 H), (0426) 7.30-7.26 (m, 1 H), 7.02-7.00 (t, / = 7 Hz, 1 H), 3.73 (s, 3 H), 3.37 (s, 3 H); (0427) [0403] LCMS: m/z = 206.0 [M+H], RT = 2.27 minutes; (Program PI, Column v.

The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott, K.; PRIESTLEY, Tony; KUNDU, Mrinalkanti; SAHA, Ashis; NATH, Suvadeep; (126 pag.)WO2018/64135; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63237-88-7, name is Pyrazolo[1,5-a]pyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. Safety of Pyrazolo[1,5-a]pyridine-2-carboxylic acid

To a stirred solution of pyrazolo[1,5-a]pyridine-2-carboxylic acid (2.01 g, 12.4 mmol) in 65 mL of dry tetrahydrofuran (THF) cooled at 0 C, under nitrogen, were slowly added 31 mL (62.1 mmol) of a 2 M solution of borane dimethyl sulfide in toluene. After 30 min. at room temperature, the solution was heated at 65 ºC for 5 h, and then cooled to 0 ºC to add 15 mL of water. After addition of 8 mL of 6N solution of HCl, the mixture was refluxed for 2 h. Finally, the organic solvent was removed under reduced pressure, 40 mL of methanol were added and concentrated. The residue was solved in ethyl acetate, and washed with aqueous NaOH 10% solution and water. The organic layers were dried (Na2SO4) and concentrated to afford 1.42 g (77%) of pyrazolo[1,5-a]pyridin-2-ylmethanol as a colorless oil.

The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; Diaz-Fernandez,Jose-Luis; Cuberes-Altisent,Mª Rosa; EP2631236; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 63237-88-7, Pyrazolo[1,5-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 63237-88-7, blongs to pyridine-derivatives compound. Product Details of 63237-88-7

Preparation 98Methyl 6-({Gamma(1 R)-1 -(4-fluorophenyl)propyll(pyrazolori ,5-alpyridin-2- ylcarbonyl)amino}methyl)pyridine-2-carboxylateTo a stirred solution of amine from Preparation 17 (42mg, 0.14mmol) in dichloromethane (1 ml_) was added pyrazolo[1 ,5-a]pyridine-2-carboxylic acid (22.5mg, 0.14mmol) followed by triethylamine (39muIota_, 0.278mmol) and N-(3- dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (26.6mg, 0.14mmol). The reaction was stirred at room temperature for 40 hrs after this time TLC showed only a small amount of conversion. 0-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (52.7mg, 0.14mmol) was added along with triethylamine (39muIota_, 0.278mmol). The reaction mixture was stirred over the weekend. The reaction was then washed with aqueous citric acid, followed by saturated aqueous NaHC03, dried (MgS04) and concentrated in vacuo. The residue was purified by column chromatography (silica, 50% ethyl acetate in pentane as eluent) to give the title compound (10mg, 16%). 1 H NMR (400 MHz, CDCI3): the compound appears to exist as two non-interconverting rotameric forms in CDCI3 in the ratio ca. 2:1. Data for these rotamers are listed separately.Major: delta ppm: 1 .96-2.07 (m, 2H) 3.99 (s, 3H) 4.68 (d, 1 H) 4.92 (d, 2H) 6.07 (t, 1 H) 6.78-6.85 (m, 3H) 6.98 (s, 1 H) 7.12-7.21 (m, 2H) 7.29-7.37 (m, 1 H) 7.40-7.52 (m, 2H) 7.56-7.62 (m, 1 H) 7.86 (d, 1 H) 8.50 (d, 1 H)Minor: delta ppm: 2.08-2.19 (m, 2H) 3.99 (s, 3H) 5.00 (d, 1 H) 5.43 (d, 2H) 6.00 (t, 1 H) 6.71 (t, 1 H) 6.78-6.85 (m, 3H) 7.08 (t, 1 H) 7.29-7.37 (m, 1 H) 7.40-7.52 (m, 2H) 7.56- 7.62 (m, 1 1-1) 7.80 (d, 1 H) 8.16 (d, 1 H).LRMS (ESI) m/z 469 [M+Na]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63237-88-7, its application will become more common.

Reference:
Patent; PFIZER LIMITED; GLOSSOP, Paul Alan; PALMER, Michael John; ANDREWS, Mark David; WO2012/120398; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 63237-88-7, Pyrazolo[1,5-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 63237-88-7, blongs to pyridine-derivatives compound. Formula: C8H6N2O2

[00274] A mixture of 0.1 g [1 ,3]thiazolo[5,4-e][1 ,3]benzothiazol-2-amine, 0.094 g pyrazolo[1 ,5-a]pyridine-2-carboxylic acid, 0.275 g HATU, and 0.156 g DIEA were stirred at 50C in 9 mL of dry THF for 8 hours. The mixture was diluted with water and the precipitate was recrystallized from methanol/DMF to yield 0.07 g of N-([1 ,3]thiazolo[5,4-e][1 ,3]benzothiazol-2- yl)pyrazolo[1 ,5-a]pyridine-2-carboxamide.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63237-88-7, its application will become more common.

Reference:
Patent; KINEATA INC; Ladonato, Shawn P.; Bedard, Kristin M.; Munoz, Ernesto J.; Imanaka, Myra W.; Fowler, Kerry W.; (122 pag.)WO2014/113492; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 63237-88-7, Pyrazolo[1,5-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 63237-88-7, blongs to pyridine-derivatives compound. Recommanded Product: 63237-88-7

Step (d) N-((ls,4s)-4-(2-(3′-(((3S,5R)-3,5-dimethylpiperazin-l-yl)methyl)biphenyl-3- yloxyJ-S-fluoronicotinamidoJcyclohexylJpyrazolo [ 1 ,5-a] pyridine-2-carboxamideTo a suspension of N-((ls,4s)-4-aminocyclohexyl)-2-(3′-(((3S,5R)-3,5-dimethylpiperazin-l- yl)methyl)biphenyl-3-yloxy)-5-fluoronicotinamide (210 mg, 0.35 mmol) in acetonitrile (4.2 mL) was added pyrazolo[l,5-a]pyridine-2-carboxylic acid (70.4 mg, 0.43 mmol) and triethylamine (484 mul, 3.47 mmol). 1-Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (277 mul, 0.43 mmol) was then added and the mixture stirred at RT for 2 hours. The mixture was evaporated to dryness and the residue dissolved in DCM (100 mL) and washed with saturated NaHCO3 (aq), brine, dried (MgSO^ and evaporated to give a foam. This was purified by HPLC to give the title compound as a white solid. Yield: 197 mg 1H NMR (400 MHz, CD3OD) delta 8.48 (d, J = 7.2 Hz, IH), 8.39 (d, J = 7.5 Hz, IH), 8.13 (d, J = 3.1 Hz, IH), 8.10 – 8.05 (m, IH), 7.68 – 7.63 (m, IH), 7.58 – 7.55 (m, IH), 7.54 – 7.47 (m, 3H), 7.45 – 7.42 (m, IH), 7.36 – 7.17 (m, 4H), 6.96 – 6.92 (m, 2H), 4.19 – 4.12 (m, IH), 4.04 -3.97 (m, IH), 3.72 (s, 2H), 3.44 – 3.34 (m, 2H), 3.15 – 3.09 (m, 2H), 2.20 (t, J = 12.4 Hz, 2H),1.98 – 1.68 (m, 8H), 1.24 (d, J = 6.7 Hz, 6H). MS: [M+H]+=676 (calc=676) (MultiMode+)

The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 63237-88-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63237-88-7, name is Pyrazolo[1,5-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of compound B-141 (8.0 g, 49 mmol) in anhydrous tetrahydrofuran (80 mL) was added DIBAL-H (98 mL, 1 M in hexane) dropwise at -78 C. The mixture was stirred at -78 C for 2 hours until TLC showed the reaction was complete. The reaction was quenched with 50 mL of aqueous saturated ammonium chloride solution at 0 C and filtered, and the filtrate was concentrated in vacuo to give compound B-142 (5.7 g, crude) as a brown oil. The crude product was used for the next step without any further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63237-88-7, Pyrazolo[1,5-a]pyridine-2-carboxylic acid.

Reference:
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63237-88-7, name is Pyrazolo[1,5-a]pyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. Safety of Pyrazolo[1,5-a]pyridine-2-carboxylic acid

To a stirred solution of pyrazolo[1,5-a]pyridine-2-carboxylic acid (2.01 g, 12.4 mmol) in 65 mL of dry tetrahydrofuran (THF) cooled at 0 C, under nitrogen, were slowly added 31 mL (62.1 mmol) of a 2 M solution of borane dimethyl sulfide in toluene. After 30 min. at room temperature, the solution was heated at 65 ºC for 5 h, and then cooled to 0 ºC to add 15 mL of water. After addition of 8 mL of 6N solution of HCl, the mixture was refluxed for 2 h. Finally, the organic solvent was removed under reduced pressure, 40 mL of methanol were added and concentrated. The residue was solved in ethyl acetate, and washed with aqueous NaOH 10% solution and water. The organic layers were dried (Na2SO4) and concentrated to afford 1.42 g (77%) of pyrazolo[1,5-a]pyridin-2-ylmethanol as a colorless oil.

The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; Diaz-Fernandez,Jose-Luis; Cuberes-Altisent,Mª Rosa; EP2631236; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 63237-88-7, Pyrazolo[1,5-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 63237-88-7, blongs to pyridine-derivatives compound. Product Details of 63237-88-7

Preparation 98Methyl 6-({Gamma(1 R)-1 -(4-fluorophenyl)propyll(pyrazolori ,5-alpyridin-2- ylcarbonyl)amino}methyl)pyridine-2-carboxylateTo a stirred solution of amine from Preparation 17 (42mg, 0.14mmol) in dichloromethane (1 ml_) was added pyrazolo[1 ,5-a]pyridine-2-carboxylic acid (22.5mg, 0.14mmol) followed by triethylamine (39muIota_, 0.278mmol) and N-(3- dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (26.6mg, 0.14mmol). The reaction was stirred at room temperature for 40 hrs after this time TLC showed only a small amount of conversion. 0-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (52.7mg, 0.14mmol) was added along with triethylamine (39muIota_, 0.278mmol). The reaction mixture was stirred over the weekend. The reaction was then washed with aqueous citric acid, followed by saturated aqueous NaHC03, dried (MgS04) and concentrated in vacuo. The residue was purified by column chromatography (silica, 50% ethyl acetate in pentane as eluent) to give the title compound (10mg, 16%). 1 H NMR (400 MHz, CDCI3): the compound appears to exist as two non-interconverting rotameric forms in CDCI3 in the ratio ca. 2:1. Data for these rotamers are listed separately.Major: delta ppm: 1 .96-2.07 (m, 2H) 3.99 (s, 3H) 4.68 (d, 1 H) 4.92 (d, 2H) 6.07 (t, 1 H) 6.78-6.85 (m, 3H) 6.98 (s, 1 H) 7.12-7.21 (m, 2H) 7.29-7.37 (m, 1 H) 7.40-7.52 (m, 2H) 7.56-7.62 (m, 1 H) 7.86 (d, 1 H) 8.50 (d, 1 H)Minor: delta ppm: 2.08-2.19 (m, 2H) 3.99 (s, 3H) 5.00 (d, 1 H) 5.43 (d, 2H) 6.00 (t, 1 H) 6.71 (t, 1 H) 6.78-6.85 (m, 3H) 7.08 (t, 1 H) 7.29-7.37 (m, 1 H) 7.40-7.52 (m, 2H) 7.56- 7.62 (m, 1 1-1) 7.80 (d, 1 H) 8.16 (d, 1 H).LRMS (ESI) m/z 469 [M+Na]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63237-88-7, its application will become more common.

Reference:
Patent; PFIZER LIMITED; GLOSSOP, Paul Alan; PALMER, Michael John; ANDREWS, Mark David; WO2012/120398; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem