Category: 6345-27-3

Electric Literature of 6345-27-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6345-27-3, name is Isonicotinimidamide hydrochloride, molecular formula is C6H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A-3. 6-Methyl-2-(4-pyridinyl)-4-pyrimidinol — A mixture containing 15.8 g.of isonicotinamidine hydrochloride, 16.8 g. of sodium methoxide, 17 g. of ethyl acetoacetate and 100 ml. of ethanol was refluxed with stirring for seven hours and then evaporated to dryness. The residue was dissolved in water and the aqueous solution made acidic with acetic acid. The resultingsolution was collected, washed with water, dried and recrystallized from ethanol to yield 6.7 g. of 6-methyl-2-(4-pyridinyl)-4-pyrimidinol, m.p. 236 -238 C.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6345-27-3, Isonicotinimidamide hydrochloride.

Reference:
Patent; Sterling Drug Inc.; US3992380; (1976); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6345-27-3, Isonicotinimidamide hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6345-27-3, blongs to pyridine-derivatives compound. Safety of Isonicotinimidamide hydrochloride

General procedure: The mixture of a chalcone 6a?6i (0.002 mol) in DMSO (5 mL), isonicotinimidamide·HCl (0.003 mol) and potassium carbonate (0.006 mol) was refluxed at 100?110°C for 6?8 h. Upon completion of the reaction, the mixture was poured into ice water and extracted with ethyl acetate. The extract was washed with dil. HCl, 5percent bicarbonate and brine solution. Organic layer was dried over sodium sulfate and concentrated to give a crude product which was purified by column chromatography (hexane : EtOAc =3 : 1). 7-Hydroxy-2,2-dimethyl-6-[6-phenyl-2-(pyridin-4-yl)pyrimidin-4-yl]chroman-4-one (6a). Off white solid, yield 67percent, mp 210?212°C. IR spectrum, nu, cm?1: 1163 (O?C), 1290 (Ar-O), 1552 (C=C), 1579, 1681(C=O), 2964. 1H NMR spectrum, delta, ppm: 14.72 s (1H,Ar-OH), 8.84 br.s (2H, pyridyl-H), 8.58 s (1H, Ar-H),8.27?8.24 m (4H, pyridyl-H, Ar-H), 8.18 s (1H,pyrimidine-H), 7.59 m (3H, Ar-H), 6.54 s (1H, Ar-H),2.76 s (2H, CH2), 1.51 s (6H, 2CH3). 13C NMR spectrum,delta, ppm: 190.81, 167.84, 165.47, 164.57, 163.98,160.32, 150.73, 143.65, 136.09, 131.78, 129.16,127.53, 127.39, 113.86, 112.11, 109.53, 105.94, 80.22,48.98, 26.88. Found, percent: C 73.70; H 4.93; N 9.84. C26H21N33. Calculated, percent: C 73.74; H 5.00; N 9.92. M 424 [M + H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6345-27-3, its application will become more common.

Reference:
Article; Ashok; Kumar, R. Suneel; Mohan Gandhi; Jayashree; Russian Journal of General Chemistry; vol. 86; 6; (2016); p. 1396 – 1404; Zh. Obshch. Khim.; vol. 86; 6; (2016); p. 1396 – 1404,9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6345-27-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6345-27-3, name is Isonicotinimidamide hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The mixture of a chalcone 6a?6i (0.002 mol) in DMSO (5 mL), isonicotinimidamide·HCl (0.003 mol) and potassium carbonate (0.006 mol) was refluxed at 100?110°C for 6?8 h. Upon completion of the reaction, the mixture was poured into ice water and extracted with ethyl acetate. The extract was washed with dil. HCl, 5percent bicarbonate and brine solution. Organic layer was dried over sodium sulfate and concentrated to give a crude product which was purified by column chromatography (hexane : EtOAc =3 : 1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6345-27-3, Isonicotinimidamide hydrochloride.

Reference:
Article; Ashok; Kumar, R. Suneel; Mohan Gandhi; Jayashree; Russian Journal of General Chemistry; vol. 86; 6; (2016); p. 1396 – 1404; Zh. Obshch. Khim.; vol. 86; 6; (2016); p. 1396 – 1404,9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6345-27-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6345-27-3, name is Isonicotinimidamide hydrochloride, molecular formula is C6H8ClN3, molecular weight is 157.6, as common compound, the synthetic route is as follows.

To a stirred solution of G-1 (2.5 g, 6.4 mmol) in ethanol (24 mL) was added, at room temperature isonicotinimidamide hydrochloride H-1 (1.5 g, 9.65 mmol) followed by potassium tert-butoxide (1.44 g, 12.9 mmol). [0112] The reaction mixture was then heated at 80° C. for 16 hours. After 100percent consumption of G-1 (monitoring by LCMS), the reaction mixture was allowed to cool to room temperature and concentrated in vacuum. The residue was, then, diluted with dichloromethane (150 mL) and treated with water (150 mL). The aqueous crude mixture was extracted with dichloromethane (2×150 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuum. The crude compound was then purified on silica gel using dichloromethane/ethyl acetate: 50/50 to afford the desired intermediate I-1 as a light white solid (2.58 g, 90percent yield).

Statistics shows that 6345-27-3 is playing an increasingly important role. we look forward to future research findings about Isonicotinimidamide hydrochloride.

Reference:
Patent; Bonfanti, Jean-Francois; Muller, Philippe; Doubler, Frederic Marc Maurice; Fortin, Jerome Michel Claude; Lounis, Nacer; US2015/87651; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 6345-27-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6345-27-3, name is Isonicotinimidamide hydrochloride. A new synthetic method of this compound is introduced below.

2. 2-(4-Pyridinyl)-4-pyrimidinamine – A mixture containing 5.4 g. of sodium methoxide, 50 ml. of methanol and 31.6 g. of isonicotinamidine hydrochloride was stirred for thirty minutes and stripped to dryness to remove the solid. To the residue was added 250 ml. of tetrahydrofuran and the resulting slurry was stirred in an ice bath. To the stirred mixture was added dropwise over a period of thirty minutes 18 g. of alpha-chloroacrylonitrile. After the reaction mixture had been stirred for an additional two hours, it was allowed to stand at room temperature for one hour and then refluxed for four hours. To the reaction mixture was added 15 ml. of 35percent aqueous sodium hydroxide solution and the mixture chilled. The solid was collected, washed with water and dried to yield 21.1 g. of 2-(4-pyridinyl)-4-pyrimidinamine, m.p. 264°-267° C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6345-27-3, its application will become more common.

Reference:
Patent; Sterling Drug Inc.; US4109092; (1978); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6345-27-3, name is Isonicotinimidamide hydrochloride, molecular formula is C6H8ClN3, molecular weight is 157.6, as common compound, the synthetic route is as follows.Computed Properties of C6H8ClN3

General procedure: In a 50 mL R.B. flask, chalcone (3, 2 mmol) and amidine ( 5, 2 mmol) in the presence of base NaH (3 mmol) were stirred in DMF (10 ml) at 135-140 oC. After the completion of reaction, reaction mixture was poured in cold water with vigorous stirring and neutralized it with N/5 HCl solution. The precipitate was filtered and dried. The crude was purified by column chromatography with a mixture of chloroform-methanol to give the desired product 6.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6345-27-3, Isonicotinimidamide hydrochloride, and friends who are interested can also refer to it.

Reference:
Article; Pathak, Vinay; Maurya, Hardesh K.; Sharma, Sandeep; Srivastava, Kishore K.; Gupta, Atul; Bioorganic and Medicinal Chemistry Letters; vol. 24; 13; (2014); p. 2892 – 2896;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 6345-27-3 , The common heterocyclic compound, 6345-27-3, name is Isonicotinimidamide hydrochloride, molecular formula is C6H8ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Isonicotinamidine hydrochloride (5.0Og, 31.7mmol) and acetaldehyde dimethylacetal (8.44mL, 63.5mmol) were combined and heated to 1100C in anhydrous DMF (35mL) in the presence of DBU (14.2OmL, 95.2mmol) for 3h. The reaction mixture was cooled to 200C, then stirred for 16h, before being concentrated in vacuo. The residue was partitioned between H2O(10OmL) and EtOAc (10OmL). The aqueous layer was extracted with EtOAc (2x50mL), then the combined organics were washed with brine (5OmL), dried (MgSO4), filtered and concentrated under reduced pressure. Flash column chromatography (EtOAc) of the residue gave 4-methyl-2-pyridin-4-yl-pyrimidine: deltaH ((CDj)2SO): 2.57 (3H, s), 7.45 (IH, d), 8.21-8.26 (2H, m), 8.72-8.77 (2H, m), 8.82 (IH, d). To a solution of this compound (1.06g, 6.17mmol) in anhydrous dioxane (2OmL) was added SeO2 (2.05g, 18.51mol), then the mixture was heated to reflux for 9Oh. The reaction mixture was cooled to 200C then filtered, washing with EtOAc. The filtrate was evaporated to dryness, then the residue was suspended in CH2Cl2. The suspension was filtered, washing with CH2Cl2, then the filtrate was evaporated to dryness to furnish the title compound: deltaH (CDCl3): 7.80 (IH, d), 8.38 (2H, d), 8.83 (2H, d), 9.13 (IH, d),10.15 (IH, s).

The synthetic route of 6345-27-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PROSIDION LTD.; WO2006/70208; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6345-27-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6345-27-3 as follows.

3. 2-(4-Pyridinyl)-4-pyrimidinamine – A mixture containing 31.6 g. of isonicotinamidine hydrochloride, 10.8 g. of sodium methoxide and 200 ml. of ethanol was stirred at ambient temperature for 30 minutes and then cooled in a running water bath. To the stirred mixture was added 18 g. of alpha-chloroacrylonitrile dropwise over a period of 25 minutes whereupon the internal temperature arose to 45° C. The reaction mixture was stirred for thirty minutes and then refluxed for two hours. To the reaction mixture was added 13 ml. of 35percent aqueous sodium hydroxide solution and the mixture was cooled. The solid was collected, washed successively with water and ethanol and dried to yield 16.8 g. of 2-(4-pyridinyl)-4-pyrimidinamine, m.p. 261°-263° C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6345-27-3, its application will become more common.

Reference:
Patent; Sterling Drug Inc.; US4109092; (1978); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6345-27-3 , The common heterocyclic compound, 6345-27-3, name is Isonicotinimidamide hydrochloride, molecular formula is C6H8ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A 20 mL of Schlenk tube equipped with a stir bar was charged with benzyl bromides (0.12 mmol), aryl amidines (0.1 mmol), S8 (0.1 mmol), LiOtBu (0.4 mmol). The tube was sealed with a Teflon lined cap, and the reaction mixture was stirred at 140 ¡ãC for 12 h in oil bath. Then the solvent was concentrated in vacuum and the residue was purified by flash column chromatography on silica gel with petroleum ether-EtOAc as the eluent to give the desired product.

The synthetic route of 6345-27-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Zhen; Liu, Miaochang; Sun, Song; Yao, En; Liu, Suqin; Wu, Zhiwen; Yu, Jin-Tao; Jiang, Yan; Cheng, Jiang; Tetrahedron Letters; vol. 58; 26; (2017); p. 2571 – 2573;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 6345-27-3 , The common heterocyclic compound, 6345-27-3, name is Isonicotinimidamide hydrochloride, molecular formula is C6H8ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Anoven-dried 10mLvialwas charged with CuI (9mg, 0.05mmol),K3PO4 (318 mg, 1.5 mmol), pivalic acid (20 mg, 0.2 mmol), a 1-(2-bromophenyl)methanamine 1 (0.5 mmol), and an amidinium salt 2or an imidate salt 4 (0.5 mmol) under air. After sealing the vial, dry1,2-dichlorobenzene (3 mL) was added by syringe and the reactionmixture was stirred at 110 C (oil bath temperature) for 18 h. Aftercooling to room temperature, the vial was opened and the reactionmixturewas partitioned between CH2Cl2 (30 mL) and brine (20 mL).The aqueous phase was extracted with CH2Cl2 (220 mL). Thecombined organic layers were dried over anhydrous MgSO4 andconcentrated in vacuum. The residue was purified by flash chromatographyon silica gel to afford the desired product.

The synthetic route of 6345-27-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Omar, Mohamed A.; Conrad, Ju?rgen; Beifuss, Uwe; Tetrahedron; vol. 70; 18; (2014); p. 3061 – 3072;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem