Category: 636-73-7

Shibata, Katsumi published the artcileNiacin activity of 3-cyanopyridine, pyridine 3-sulfonic acid, nicotinic acid N-oxide, and 6-hydroxynicotinic acid in rats, Application In Synthesis of 636-73-7, the publication is Bitamin (1995), 69(7), 357-64, database is CAplus.

Niacin activity of the niacin related compounds such as 3-cyanopyridine, pyridine 3-sulfonic acid, nicotinic acid N-oxide, and 6-hydroxynicotinic acid was investigated using rats. 3-Cyanopyridine, pyridine-3-sulfonic acid, and 6-hydroxynicotinic acid had not only niacin activity but also the antagonistic activity. Nicotinic acid N-oxide had niacin activity and the relative niacin activity to nicotinic acid was about 1/2 in molar ratio.

Bitamin published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C14H10O4S2, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Watanabe, Takashi published the artcileOrganic synthesis unit process-thiochemicals and heterocyclic compounds: heterocyclic compounds (part 1), Quality Control of 636-73-7, the publication is Fain Kemikaru (2013), 42(8), 53-66, database is CAplus.

Unit processes of various heterocyclic compounds including furan derivatives, THF or its derivatives, chroman, thiophene or its derivatives, tetrahydrothiophene, pyrrole or its derivatives, pyrrolidine or its derivatives, indole derivative, pyridine derivatives, piperidine derivatives, and quinoline or its derivatives are described. Thus, 2,6-dibromo-4-nitrophenol 8, glycerin 20, and concentrated H₃PO₄ 12 g were charged to a 3-neck flask fitted with a stirrer, a reflux condenser, and a thermometer, cooled, treated slowly with concentrated H₂SO₄ with stirring well, heated in a oil bath at 150-160° for 3 h with gentle refluxing, and cooled. Water (∼150 mL) was added to the flask content solidified, throughly pulverized, and filtered to sep. the insoluble residue and the filtrate. The insoluble residue was immersed in warm 5% aqueous HCl solution and left to be cooled to readily precipitate colorless needle crystals which were filtered off. The filtrate was concentrated to give addnl. crystalline salt. The combined crystalline salt (3.55 g) was added to slightly acidic aqueous Na₂CO₃ solution, throughly stirred, left to stand for ∼20 min, and the free amine formed (2.87 g) was filtered off and recrystallized from acetone to give 7-bromo-6-hydroxyquinoline. The filtrate from the aqueous Na₂CO₃ solution was neutralized with Na₂CO₃, followed by filtering off the precipitated free amine (0.72 g) and recrystallization from acetone to give 7-bromo-6-hydroxyquinoline in ∼62% as crude product.

Fain Kemikaru published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C4H7BN2O2, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

El Ali, Bassam published the artcileRh₆(CO)₁₆-H₃PW₁₂O₄₀-catalyzed one pot hydroformylation-cyclotrimerization of cyclohexene and cyclopentene to 2,4,6-trisubstituted 1,3,5-trioxanes, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Journal of Molecular Catalysis A: Chemical (2003), 203(1-2), 53-58, database is CAplus.

One-pot hydroformylation-cyclotrimerization of cyclopentene and cyclohexene was selectively catalyzed by Rh₆(CO)₁₆ and H₃PW₁₂O₄₀·xH₂O (HPA-W₁₂) in THF at 40 atm (CO/H₂ = 1/1) and afforded 2,4,6-tris(cycloalkyl)-1,3,5-trioxanes as major products along with the corresponding aldehydes.

Journal of Molecular Catalysis A: Chemical published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guven, Alaattin published the artcileAcidity study on 3-substituted pyridines, Recommanded Product: Pyridine-3-sulfonic acid, the publication is International Journal of Molecular Sciences (2005), 6(11), 257-275, database is CAplus.

A comprehensive theor. study for the protonation of some 3-substituted pyridines has been carried out in aqueous solution (ε=78.4) by semi empirical AM1 method in MOPAC2000 and PM5 method in MOPAC2002. Solvent effect was accounted for implicitly by means of the conductor like screening model (COSMO). The acidity constants of these pyridine derivatives have been calculated The tautomeric and/or conformational equilibrium for these compounds, where available, were also taken into account to find out the mol fractions of the species in aqueous media. The results obtained from the calculations were compared with the available exptl. values, and the results indicate a considerable agreement with available exptl. data.

International Journal of Molecular Sciences published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lombardini, John B. published the artcileEffects of taurine and taurine analogs on the phosphorylation of a 44 kDa protein present in a mitochondrial subfraction of the rat heart: partial characterization of the 44 kDa phosphoprotein, Quality Control of 636-73-7, the publication is Journal of Molecular and Cellular Cardiology (1994), 26(12), 1675-89, database is CAplus and MEDLINE.

Recent studies suggest that taurine (2-aminoethanesulfonic acid) is involved in the regulation of protein phosphorylation in excitable tissues such as the retina, brain and heart. To determine the structural requirements for the effect of taurine on the phosphorylation of a 44 kDa protein(s), a series of taurine analogs were tested in an in vitro assay using a subcellular mitochondrial fraction of rat heart. Inhibitors of the phosphorylation of the 44 kDa protein include taurine and close structural analogs of taurine such as aminoethylhydrogen sulfate and α-sulfo-β-alanine. Secondary amines with the taurine structure partially locked into a saturated 5-membered ring such as (±)piperidine-3-sulfonic acid and 1,2,3,4-tetrahydroquinoline-8-sulfonic acid also possess inhibitory activity. Sulfone analogs of taurine such as 2-aminoethylmethylsulfone, a non-restricted taurine analog with maximal conformational flexibility about its amino and sulfone moieties, and (±)3-aminotetrahydrothiopyran-1,1-dioxide, an analog containing the sulfone moiety in a six-membered ring structure, were more potent inhibitors of phosphorylation than taurine despite the fact that the sulfone moiety is neither an isosteric nor isoelectronic substitution for the sulfonic acid moiety. The results of this study indicate that the inhibition of the phosphorylation of the 44 kDa protein in a rat heart mitochondrial fraction is relatively specific for the taurine structure. Two analogs of taurine with unsaturated rings containing a primary sulfonic acid and a secondary amine. Pyridine-3-sulfonic acid and quinoline-8-sulfonic acid, were observed to be stimulators of the phosphorylation of the 44 kDa protein. In addition, 2-aminobenzenesulfonic acid also stimulated phosphorylation. Phase separation experiments with Triton X-114 suggest that the 44 kDa phosphoprotein is a soluble protein and not an integral membrane protein of the mitochondria. Phosphate incorporation into specific amino acids was determined by two-dimensional electrophoresis on celluloses plates and was found exclusively in the serine residues.

Journal of Molecular and Cellular Cardiology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lombardini, John B. published the artcileQuantitative analysis of the combination dose-effects of taurine and taurine analogs on the phosphorylation of an ∼44-Kd protein present in a mitochondrial subfraction of rat heart, COA of Formula: C5H5NO3S, the publication is Journal of Cardiovascular Pharmacology (1996), 28(1), 107-114, database is CAplus and MEDLINE.

Combinations of taurine and analogs of taurine that partially contain the N-C-C-S moiety within a semirigid saturated ring structure were tested for their effects on the phosphorylation of an ∼44-Kd protein present in the mitochondrial fraction of rat heart. (±)-Piperidine-3-sulfonic acid (PiP), an inhibitor of the phosphorylation of the ∼44-Kd protein with activity approx. similar to that of taurine, was observed to be mutually exclusive with taurine, i.e., to have a similar mode of action. The combination of taurine plus PiP in a fixed ratio mixture of 1:1 was slightly antagonistic at all concentrations (±)-Aminotetrahydrothiopyran-1,1-dioxide (APS), a sulfone derivative of taurine with a net pos. charge, also has approx. the same inhibitory activity as taurine. However, APS was mutually nonexclusive with taurine when tested in combination and thus appears to act independently of taurine. Taurine plus APS in a fixed ratio mixture of 3:1 was highly antagonistic at low concentrations of the mixture, approached an additive relation at 50% saturation, and became synergistic at high concentrations of the mixture Three analogs of taurine, pyridine-3-sulfonic acid (PyS), quinoline-8-sulfonic acid (QS), and 2-aminobenzenesulfonic acid (ABS), that have the basic taurine structure (N-C-C-S) partially in a semirigid unsaturated ring structure stimulate the phosphorylation of the ∼44-Kd protein. Due to the unsaturated ring structure, these analogs of taurine have a net neg. charge at physiol. pH and are not zwitterions. When PyS, QS, or ABS was titrated in the presence of a fixed concentration of taurine (10 mM), there was a competitive relation even through their electronic nature is quite different than that of taurine. The combination of QS plus PyS (1:5) appears to progress through a transition from being synergistic at low concentrations of the fixed ratio mixture, additive at 50% saturation, and finally antagonistic at high concentration of the fixed ratio mixture

Journal of Cardiovascular Pharmacology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, COA of Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhu, Yinggui published the artcileElectrogenerated chemiluminescence behavior of Tb complex and its application in sensitive sensing Cd²⁺, Safety of Pyridine-3-sulfonic acid, the publication is Electrochimica Acta (2017), 1-8, database is CAplus.

The authors report a novel rare earth metal complex with the weak ligand of aromatic sulfonic acid (pyridine-3-sulfonic acid, 3-pSO₃H), and characterized by FTIR, UV-visible, energy-dispersive x-ray spectroscopy (EDX), electrochemiluminescence spectra, etc. Then an excellent electrochemiluminescence (ECL) signal was observed with K₂S₂O₈ as the coreactant in NaAc-HAc buffer solution For another thing, the electrochem. properties of the compound were thoroughly studied in MeCN solution, the possible ECL reaction mechanism is proposed as well. Also, a simple and straightforward ECL platform is reported for sensitive and selective detection of Cd²⁺ due to the effective quenching after addition of Cd²⁺. Other heavy/transition metal ions do not interfere with the sensing. The limit of detection is determined as 0.13 nM, the results suggested that as-prepared complex could be a promising material for developing ECL sensors to detect the Cd²⁺ rapidly indwell in environmental and practical samples.

Electrochimica Acta published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C38H74Cl2N2O4, Safety of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Obdyakov, V. F. published the artcileStabilization of palladium in homogeneous chlorideless catalysts of oxidation of olefins C₂-C₄ by oxygen into carbonyl compounds, HPLC of Formula: 636-73-7, the publication is Kataliz v Promyshlennosti (2007), 19-25, database is CAplus.

The first step of homogeneous oxidation of olefins C₂-C₄ by oxygen in the presence of catalyst Pd + GPK-x, were GPK-x is phosphovanadomolybdic heteropoly acid H_3+xPV^V_x Mo_12-xO₄₀, consist in reduction of GPK-x with olefin in the presence Pd-complexes at 30-60° into H_mGPK-x where m=[V^IV]_∑/[GKP-x] – is excellent reduction catalyst. In this case the redox-system Pd¹₂/Pd⁰₂ works and with increasing of temperature in converts into system Pd²⁺/Pd_MET with higher redox-potential. During this transformation interval of values m is diminished where the catalyst remained as homogeneous and from reduced solution metallic Pd begins to precipitate To prevent the Pd precipitation it needs to introduce in catalyst the stabilizers stable from oxidation As stabilizers can be used 3-pyridinesulfonic acid of more cheaper 2,6-pyridinecarboxylic (dipicolinic) acid (I). In the presence of the stabilizers the activity of catalyst is diminished but the area of its homogeneity will extend. Complexes of Pd with I are stable at temperatures of regeneration of catalyst (150-160°). Therefore I is considered as rather perspective stabilizer of Pd in catalysts Pd + GPK-x and can be used in industrial homogeneous processes of oxidation of olefins C₂-C₄ with oxygen.

Kataliz v Promyshlennosti published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, HPLC of Formula: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jia, Jing-jing published the artcileSynthesis, structure and magnetic analysis of the cobalt polymer based on N-[(3-pyridine)-sulfonyl]aspartate, Product Details of C5H5NO3S, the publication is Chinese Journal of Structural Chemistry (2017), 36(2), 266-272, database is CAplus.

One new cobalt polymer [Co(L)·3H₂O]_n (1, H₂L = N-[(3-pyridine)-sulfonyl]aspartate) has been synthesized and characterized by single-crystal x-ray diffraction and elemental anal. Polymer 1 belongs to the monoclinic system, space group P21/n with a = 11.479(2), b = 7.3180(15), c = 16.424(3) Å, β = 109.56(3) °, V = 1300.1(5) ų, M_r = 385.22, Z = 12, F(000) = 790, S = 1.054, R = 0.0670, wR = 0.1147,(Δρ)_max = 1.158 and (Δρ)_min = -0.754 e/ų. TGA showed that the polymer first lost one coordinated water mol. and then another two coordinated water mols. The values of the Curie and Curie-Weiss constants of polymer 1 are Cm = 2.67 cm³ mol^-1 K and θ = -21.66 K.

Chinese Journal of Structural Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Limin published the artcileLow-frequency vibrational modes of DL-homocysteic acid and related compounds, Synthetic Route of 636-73-7, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2009), 73A(5), 884-891, database is CAplus and MEDLINE.

Several polycrystalline mols. with sulfonate groups and some of their metal complexes, including DL-homocysteic acid (DLH) and its Sr- and Cu-complexes, pyridine-3-sulfonic acid and its Co- and Ni-complexes, sulfanilic acid and -cysteic acid were studied using THz time-domain methods at room temperature The results of THz absorption spectra show that the mols. have characteristic bands at 0.2-2.7 THz (6-90 cm^-1). THz technique can be used to distinguish different mols. with sulfonate groups and to determine the bonding of metal ions and the changes of H bond networks. In the THz region DLH has three bands: 1.61, 1.93 and 2.02 THz; and 0.85, 1.23 and 1.73 THz for Sr-DLH complex, 1.94 THz for Cu-DLH complex, resp. The absorption bands of pyridine-3-sulfonic acid are located at 0.81, 1.66 and 2.34 THz; the bands at 0.96, 1.70 and 2.38 THz for its Co-complex, 0.76, 1.26 and 1.87 THz for its Ni-complex. Sulfanilic acid has three bands: 0.97, 1.46 and 2.05 THz; and the absorption bands of -cysteic acid are at 0.82, 1.62, 1.87 and 2.07 THz, resp. The THz absorption spectra after complexation are different from the ligands, which indicate the bonding of metal ions and the changes of H bond networks. M-O and other vibrations appear in the FIR region for those metal-ligand complexes. The bands in the THz region were assigned to the rocking, torsion, rotation, wagging and other modes of different groups in the mols. Preliminary assignments of the bands were carried out using Gaussian program calculation

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C11H21BF4N2O2, Synthetic Route of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem